Isolation and structure determination of four novel diterpenes from jatropha curcus

Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities

“…The nine known diterpenoids were identified as jatrophol (4), jatropholone A (5), jatropholone B (6), curcusone B (7), curcusone C (8), curcusone D (9), 4E-jatrogrossidentadion (10), 15-epi-4E-jatrogrossidentadion (11) and 2-epi-hydroxyisojatrogrossidion (12) by comparison of their spectroscopic data with the reported data (Naengchomnong et al, 1994(Naengchomnong et al, , 1986Ravindranath et al, 2004;Chianese et al, 2011).…”

“…J. curcas has served globally as a source of lamp oil and soap, and also as a medicinal plant for the treatment of dropsy, paralysis, rheumatism, and certain skin diseases for a long time (Jiangsu New Medicinal College, 1977). Previous investigations on the secondary metabolites of J. curcas had resulted in the isolation of diterpenoids (Naengchomnong et al, 1994(Naengchomnong et al, , 1986Ravindranath et al, 2003Ravindranath et al, , 2004Chianese et al, 2011;Wang et al, 2009;Liu et al, 2012), sesquiterpenoids (Wang et al, 2008), flavonoids (Khafagy et al, 1977;Subramanian et al, 1971), lignans (Li et al, 2010), coumarins (Kong et al, 1996;Mitra et al, 1970;Matsuse et al, 1999) and cyclic peptides (Van den Berg et al, 1995;Auvin et al, 1997) with various biological activities. In order to isolate the minor active compounds, we investigated this plant and obtained three new diterpenoids along with nine known ones from the CHCl 3 extract of the root bark.…”

New Lignans from Jatropha curcas Linn.

“…The main difference between them was that the hydroxymethyl was replaced by a methyl group in 3, which led to upfield shifts of H-9 [δ H = 1.44 (3H, d, J = 6. 3.84 (1H, m, H-9 a), and 3.77 (1H, m, H-9 b) were assigned to moieties CH(7)/CH(8)/CH 2 (9), CH(7 )/CH(8 )/CH 2 (9 ) and CH(8)/CH (8). The location of two acetoxy groups on C-9 and C-9 was confirmed by HMBC correlations between H-9 and H-9 with the carbonyl carbons at δ C = 170.9 and 170.7, respectively.…”

Antimicrobial and Anti-Inflammatory Activity of Press Cake of Jatropha curcas

“…They are generally found in plant species of the families Euphorbiaceae and Thymelaeceae. Recently, various forms of phorbol esters have been isolated from J. curcas aerial parts and seed oil [10][11][12]. Generally, due to toxicity it causes tumor promotion, skin inflammation, activation of blood platelets, tissue damage, lymphocyte mitogenesis, stimulation of degranulation in neutrophils in living cells and prostaglandin production [8,13].…”