Isolation and Structure Elucidation of a Novel Glycoside Niazidin from the Pods of Moringa oleifera

Faizi, Shaheen; Siddiqui, Bina Shaheen; Saleem, Rubeena; Fatima, Nosheen; Husnain, Shazia

doi:10.1021/np970038y

Cited by 27 publications

(19 citation statements)

References 23 publications

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“…The pods of M. oleifera contain a glycoside niazine possessing an o-nitrile thiocarbamate group along with thiocarbonate, carbamate and isothiocyanate glycosides, which are considered to have hypotensive effects (Faizi et al, 1997).…”

Section: Plants Containing Multibioactive Compoundsmentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

378

214

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Livestock and aquaculture production is under political and social pressure, especially in the European Union (EU), to decrease pollution and environmental damage arising due to animal agriculture. The EU has banned the use of antibiotics and other chemicals, which have been shown to be effective in promoting growth and reducing environment pollutants because of the risk caused to humans by chemical residues in food and by antibiotic resistance being passed on to human pathogens. As a result of this, scientists have intensified efforts in exploiting plants, plant extracts or natural plant compounds as potential natural alternatives for enhancing the livestock productivity. This paper discusses work on the effects of various phytochemicals and plant secondary metabolites in ruminant and fish species. The focus is on (i) plants such as Ananas comosus (pine apple), Momordica charantia (bitter gourd) and Azadirachta indica (neem) containing anthelmintic compounds and for their use for controlling internal parasites; (ii) plants containing polyphenols and their applications for protecting proteins from degradation in the rumen, increasing efficiency of microbial protein synthesis in rumen and decreasing methane emission; for using as antioxidants, antibacterial and antihelmintic agents; and for changing meat colour and for increasing n-3 fatty acids and conjugated linoleic acid in meat; (iii) saponin-rich plants such as quillaja, yucca and Sapindus saponaria for increasing the efficiency of rumen fermentation, decreasing methane emission and enhancing growth; for producing desired nutritional attributes such as lowering of cholesterol in monogastric animals; for increasing growth of fish (common carp and Nile tilapia) and for changing male to female ratio in tilapia; and for use as molluscicidal agents; (iv) Moringa oleifera leaves as a source of plant growth factor(s), antioxidants, beta-carotene, vitamin C, and various glucosinolates and their degraded products for possible use as antibacterial, antioxidant, anticarcinogenic and antipest agents; (v) Jatropha curcas toxic variety with high levels of various phytochemicals such as trypsin inhibitor, lectin, phytate and phorbol esters in seeds limiting the use of seed meal in fish and livestock diets; and the use of phorbol esters as bio-pesticidal agent; and (vi) lesser-known legumes such as Entada phaseoloides seeds containing high levels of trypsin inhibitor and saponins, Sesbania aculeate seeds rich in non-starch polysaccharides and Mucuna pruriens var. utilis seeds rich in L-3,4-dihydroxyphenylalanine and their potential as fish feed; Cassia fistula seeds as a source of antioxidants; and the use of Canavalia ensiformis, C. gladiata and C. virosa seeds containing high levels of trypsin inhinitor, lectins and canavanine. The paper also presents some challenges and future areas of work in this field.

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Section: Plants Containing Multibioactive Compoundsmentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

378

214

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“…It is a prolific producer of diverse secondary metabolites including glycosides preferentially rhamnosides of carbamates, thiocarbamates, nitriles, benzyl glucosinolates, thiocyanates, isothiocyanates and oxazolidine-2-thiones. Pharmacological screening of its leaf extracts exhibited hypotensive [4], cardioprotective [5], hepatoprotective [6], antidiabetic [7] and antiulcerogenic activities [8]. The pods are hypotensive [9] while seeds showed antibacterial [10], antitumor [11], anti-inflammatory and antispasmodic activities [12].…”

Section: Introductionmentioning

confidence: 99%

Hypotensive Activity of Moringa oleifera Lam (Moringaceae) Root Extracts and its Volatile Constituents

Sana¹,

Saleem²,

Faizi³

2015

Trop. J. Pharm Res

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Purpose: To explore the hypotensive activity and chemical composition of Moringa oleifera Lam (Moringaceae) roots. Methods: The fresh roots of M. oleifera was cut into small pieces and successively extracted with petroleum ether (PE) and dichloromethane (DC). PE extract was further divided into MRP and MRP -1. DC extract showed a thick mass during evaporation which was separated as MRDC -IN. The mother liquor left was divided into MRDC and MRDC -1. All residues were analyzed by gas chromatographymass spectroscopy (GC-MS) using ZB-5 column. Identification of each extract and fraction was based on comparison of their retention indices (RI), by co-injecting authentic compounds (7, 20.3 %) , stigmastan -3, 5, diene (24, 19.32 %), methyl 14-hydroxy-5-tetradecenoate (9, 19.22 %), 1 , 11 diphenyl undecane (47, 18.78 %) and cyclopentanyl hexadecane (39, 14.44 %) were the major constituents among the various hydrocarbons, fatty acids, esters, alcohols, aldehydes, isothiocyanate, aromatics, steroids, terphenyl and sulphur-containing

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“…The stem bark has also been reported to contain alkaloids (moringinine and moringine) . In particular, this plant genus contains unusual sugar‐substituted hydroxy‐aromatic glucosinolates . Generally, glucosinolates are structurally characterized by a β‐ d ‐glucopyranosyl unit and an O ‐sulfated anomeric ( Z )‐thiohydroximate function connected to a variable side chain depending on the amino acid metabolism of the plant species .…”

Section: Introductionmentioning

confidence: 99%

“…[8] In particular, this plant genus contains unusual sugar-substituted hydroxy-aromatic glucosinolates. [9,10] Generally, glucosinolates are structurally characterized by a β-D-glucopyranosyl unit and an O-sulfated anomeric (Z)-thiohydroximate function connected to a variable side chain depending on the amino acid metabolism of the plant species. [11] M. oleifera contains several uncommon members of the glucosinolates family with peculiar characteristics given by the presence in their structure of a second saccharide residue in the aglycon side chain.…”

Section: Introductionmentioning

confidence: 99%

‘Moringa oleifera: study of phenolics and glucosinolates by mass spectrometry’

Maldini

Maksoud

Natella³

et al. 2014

J. Mass Spectrom.

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Moringa oleifera is a medicinal plant and an excellent dietary source of micronutrients (vitamins and minerals) and health-promoting phytochemicals (phenolic compounds, glucosinolates and isothiocyanates). Glucosinolates and isothiocyanates are known to possess anti-carcinogenic and antioxidant effects and have attracted great interest from both toxicological and pharmacological points of view, as they are able to induce phase 2 detoxification enzymes and to inhibit phase 1 activation enzymes. Phenolic compounds possess antioxidant properties and may exert a preventative effect in regards to the development of chronic degenerative diseases. The aim of this work was to assess the profile and the level of bioactive compounds in all parts of M. oleifera seedlings, by using different MS approaches. First, flow injection electrospray ionization mass spectrometry (FI-ESI-MS) fingerprinting techniques and chemometrics (PCA) were used to achieve the characterization of the different plant's organs in terms of profile of phenolic compounds and glucosinolates. Second, LC-MS and LC-MS/MS qualitative and quantitative methods were used for the identification and/or determination of phenolics and glucosinolates in M. oleifera.

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Isolation and Structure Elucidation of a Novel Glycoside Niazidin from the Pods of Moringa oleifera

Cited by 27 publications

References 23 publications

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Hypotensive Activity of <i>Moringa oleifera</i> Lam (Moringaceae) Root Extracts and its Volatile Constituents

‘Moringa oleifera: study of phenolics and glucosinolates by mass spectrometry’

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