Isolation and Structure Elucidation of a New Flavonol Glycoside from Sophora japonica

Si, Chuanling; Du, Zhen-Guo; Fan, Su; An, Liang-Liang

doi:10.1007/s10600-016-1780-7

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…13 C-NMR (100 MHz, DMSO- d 6 ) δ : 177.5 (C-4), 164.4 (C-7), 161.2 (C-5), 160.0 (C-4′), 156.4 (C-9), 156.2 (C-2), 133.2 (C-3), 130.9 (C-2′, 6′), 124.0 (C-1′), 115.2 (C-3′, 5′), 104.0 (C-10), 101.6 (C-1″), 99.1 (C-6), 98.8 (C-8), 77.5 (C-3″), 76.6 (C-5″), 74.2 (C-2″), 70.2 (C-4″), 61.1 (C-6″). Thus, the structure of 4 was defined as kaempferol-3- O -β- d -glucopyranoside by comparison of its MS, 1 H- and 13 C-NMR data with literature data [24].…”

Section: Resultsmentioning

confidence: 99%

Separation of Five Flavonoids from Aerial Parts of Salvia Miltiorrhiza Bunge Using HSCCC and Their Antioxidant Activities

et al. 2019

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The aerial parts of Salvia miltiorrhiza Bunge, as the non-medicinal parts, are always discarded during harvesting, resulting in a huge waste of resources and environmental pressure. Due to the high flavonoid content and their antioxidant activities characteristics, the aerial parts of S. miltiorrhiza can be developed into natural antioxidants and used in foods. A high-speed counter-current chromatography (HSCCC) method, using a two-phase solvent system composed of tert-butyl methyl ether/n-butanol/acetonitrile/water (3:1:1:20, v/v), was the first to successfully isolate five flavonoids from the aerial parts of S. miltiorrhiza in one attempt, and separately categorized as rutin (1), isoquercitrin (2), kaempferol-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (3), kaempferol-3-O-β-d-glucopyranoside (4) and apigenin-7-O-β-d-glucopyranoside (5) after identification. The purities of these plant isolates were 97.3%, 99.5%, 92.8%, 98.1% and 98.7%, respectively. All the flavonoids were identified by HR-ESI-MS, 1D and 2D NMR. Compounds 3 and 5 were firstly isolated from the plant of S. miltiorrhiza. Results from antioxidant assays showed that rutin (1) and isoquercitrin (2) had higher antioxidant capacities compared to L-ascorbic acid as the positive control.

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Section: Resultsmentioning

confidence: 99%

Separation of Five Flavonoids from Aerial Parts of Salvia Miltiorrhiza Bunge Using HSCCC and Their Antioxidant Activities

et al. 2019

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Chemical Constituents of Xylem of Sophora japonica Roots

Xiong

et al. 2018

Chem Nat Compd

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Flavonoid Compounds from the Leaves ofKalanchoe proliferaand Their Cytotoxic Activity against P-388 Murine Leukimia Cells

et al. 2017

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− Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with IC 50 values of 4.45 ± 0.05 and 6.28 ± 0.02 μg/mL, respectively.

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Isolation and Structure Elucidation of a New Flavonol Glycoside from Sophora japonica

Cited by 5 publications

References 16 publications

Separation of Five Flavonoids from Aerial Parts of Salvia Miltiorrhiza Bunge Using HSCCC and Their Antioxidant Activities

Separation of Five Flavonoids from Aerial Parts of Salvia Miltiorrhiza Bunge Using HSCCC and Their Antioxidant Activities

Chemical Constituents of Xylem of Sophora japonica Roots

Flavonoid Compounds from the Leaves ofKalanchoe proliferaand Their Cytotoxic Activity against P-388 Murine Leukimia Cells

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