“…There are more than 308 species of Macaranga, wide-spread from Africa and west region of Madagascar until tropical region of Asia, North Australia and east region of Pacific Islands (Blattner, 2001). Macaranga genus also known as a sources of terpenoid (Hui, 1971)] and phenolic (flavonoid) (Jang, 2002;Schutz, 1995;Sutthivaiyakit, 2002;Yoder, 2007) compounds which have biological activity as antioxidant (Phommart, 2005) and anticancer (cytotoxicity) (Yoder, 2007). Macarangin, a geranylated flavonoid compound is one of the flavonoid typical compounds contained in Macaranga genus, and have been isolated from M. vedeliana (Hnawia, 1990) and M. denticulate (Sutthivaiyakit, 2002).…”