Isolation of Bacteria Causing Urinary Tract Infections and their Antibiotic Susceptibility Profile at Anwer Khan Modern Medical College Hospital

Abstract

Among hospitalized patients, the most common nosocomial infection is Urinary tract infection (UTI). The knowledge about the type of pathogens responsible for UTI and susceptibility and resistance pattern of the causative agents at a specific area may help the doctors to choose correct treatment regimen. This study was aimed to investigate the antibiotic susceptibility and resistance pattern of isolated urinary pathogens. This study was done at Anwer Khan Modern Medical College Hospital, Dhaka during January- June, 2011. Out of 498 clinical samples of urine collected, 245 (49.19%) showed significant bacterial growth. The most common pathogens isolated were Escherichia coli (142, 58.0%), Streptococcus feacalis (38, 15.5%), Pseudomonus (20, 8.2%), Klebsiella species (20, 8.2%) and Staphylococcus epidermidis (14, 5.7%). Members of the Enterobacteriaceae were 75%-100%sensitive to Amikacin and Nitrofurantoin while they were found variably sensitive to other commonly used antibiotics. Pseudomonas species were found 90% sensitive to Meropenem and 70% to Amikacin. Strep. feacalis were found 94.7% sensitive to Amoxicillin, 84.2% to Amoxiclave and 78.9% to Ciprofloxacin, 65.5% to Cephalexin, 50% to Ceftriaxone. The clinicians should use Meropenem and Amikacin selectively in cases of un-responsiveness to commonly used antibiotics. Anwer Khan Modern Medical College Journal Vol. 4, No. 2: July 2013, Pages 23-27 DOI: http://dx.doi.org/10.3329/akmmcj.v4i2.16938

Clinical Utility of Antibiotic against Uropathogen Isolated at a Tertiary Care Hospital of Dhaka City

“…Majority (92.4%) of Enterobacteriaceae isolates were found to be MDR. This finding is comparable to Shilpi et al [18] in Bangladesh who has found that members of Enterobacteiacaee variably sensitive to different antibiotics. Similar susceptibility pattern was also reported by Sultana et al [19] The overall prevalence of MDR among enterobacteriaceae isolates identified from patients with symptomatic UTI was 92.4% which is similar with the results from previous study in Gondar (85.5%), Eshetie (87.4%) and Mozambique (88.2%) [20,21,22] while it was higher than reports from other study in Ethiopia: Gondar (68%), and Dessie (74.6%) [23,24] and many other countries, such as USA (19.1%), Belgium (62%), and Italy (62%), Nepal (40.1%, 64.04%).…”

Extended-Spectrum Beta-Lactamase Producing Escherichia coli and Klebsiella pneumoniae are Emerging as Major Pathogens Responsible for Urinary Tract Infection

“…In current study, it was seen that, 57% of E. coli and 62.5% of K. pneumoniae were positive for ESBL. This frequency is much higher than previous four reports from Bangladesh 5,6,13,14 . ESBL positive organisms are also increasingly being identified in Korea 15 and USA 16 .…”

“…In two different reports from Dhaka, Bangladesh, patients suffering from UTI were of much lower age, but patients having infections due to ESBL positive organisms had a mean age of 71 years in Spain 6,9,13 . In current study, it was seen that, 57% of E. coli and 62.5% of K. pneumoniae were positive for ESBL.…”

Frequency of Extended-Spectrum Beta-Lactamase Producing Organisms Causing Urinary Tract Infection and Their Antibiotic Sensitivity Pattern

“…This frequency is much higher than previous four reports from Bangladesh. 5,6,9,10 ESBL positive organisms are increasing in Korea and USA. Limitations of the study The study duration was short and sample size was small.…”