Among hospitalized patients, the most common nosocomial infection is Urinary tract infection (UTI). The knowledge about the type of pathogens responsible for UTI and susceptibility and resistance pattern of the causative agents at a specific area may help the doctors to choose correct treatment regimen. This study was aimed to investigate the antibiotic susceptibility and resistance pattern of isolated urinary pathogens. This study was done at Anwer Khan Modern Medical College Hospital, Dhaka during January- June, 2011. Out of 498 clinical samples of urine collected, 245 (49.19%) showed significant bacterial growth. The most common pathogens isolated were Escherichia coli (142, 58.0%), Streptococcus feacalis (38, 15.5%), Pseudomonus (20, 8.2%), Klebsiella species (20, 8.2%) and Staphylococcus epidermidis (14, 5.7%). Members of the Enterobacteriaceae were 75%-100%sensitive to Amikacin and Nitrofurantoin while they were found variably sensitive to other commonly used antibiotics. Pseudomonas species were found 90% sensitive to Meropenem and 70% to Amikacin. Strep. feacalis were found 94.7% sensitive to Amoxicillin, 84.2% to Amoxiclave and 78.9% to Ciprofloxacin, 65.5% to Cephalexin, 50% to Ceftriaxone. The clinicians should use Meropenem and Amikacin selectively in cases of un-responsiveness to commonly used antibiotics. Anwer Khan Modern Medical College Journal Vol. 4, No. 2: July 2013, Pages 23-27 DOI: http://dx.doi.org/10.3329/akmmcj.v4i2.16938

Background: Staphylococcus aureus (S. aureus) is a potential pathogen responsible for producing various infectious diseases. Determination of the prevalence of S. aureus infections both in animals and humans and elucidation of their antibiotic resistance pattern is crucial. The objective of this study was to find out the prevalence of Staphylococcal diseases in animals and humans, and their resistance pattern to commonly used antibiotics. Methods: A total of 100 animal and 100 human clinical samples were analyzed by traditional method. The S. aureus was identified by their cultural characteristics, gram’s staining, and catalase and coagulase tests. Antibiotic resistance pattern of the isolates was determined by disc diffusion method using various types of antibiotics. Results: The prevalence of S. aureus in animals and humans were 54% and 40%, respectively. S. aureus isolates of animal origin were highly resistant against penicillin (64.81%) and oxytetracycline (42.59%), and the lowest resistance was against oxacillin (7.40 %). S. aureus isolates from human were also showed a higher percentage of resistance against penicillin (87.5%) then oxacillin, cloxacillin, amoxicillin (37.5% each), and lowest resistance was observed against fusidic acid (5%). Conclusion: The findings of this study will certainly help veterinary clinicians or physicians to select appropriate antibiotics like oxacillin and fusidic acid for the treatment of different types of staphylococcal infections.