Isolation of Bioactive Compounds That Relate to the Anti‐Platelet Activity of <i>Cymbopogon ambiguus</i>

Grice, I. Darren; Rogers, Kelly L.; Griffiths, Lyn R.

doi:10.1093/ecam/nep213

Cited by 19 publications

(15 citation statements)

References 72 publications

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“…Research has shown that tea is suitable for relieving headaches, migraine, and inflammation, confirming the custom of aborigines who used it for headache treatment chest infections, and muscle cramps. 76…”

Section: Phytotherapy and Headachementioning

confidence: 99%

Nutrition and Phytotherapy: A Winning Combination Against Headache

Ferrara

2019

Int J Med Rev

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Introduction Headache is a pathological form of endemic character that prevents the performance of normal activities, both working and relational. It is difficult to consider both the multiple causes and the various factors competing in this event, due to the lack of objective parameters that allow the clear classification of the various types of headache. 1 Migraine, the scientific term in which headache is indicated, is classified in many categories and sub-categories considering not only the quality, intensity, and cyclicity of pain, but also the way it manifests itself. A primary headache is generally distinguished from hormonal or environmental causes, including migraine, tension headache, and cluster headache; a secondary headache is the main symptom of other disorders, such as allergies, sinusitis, hypertension, osteoarthritis, digestive difficulties; pain that manifests itself following the excessive intake of some substances such as coffee, alcohol, and drugs; pain resulting from a lack of substances such as sugars, or in particular physical conditions, physical exertion, stress, or environmental, excessive cold or altitude. 2-4 The main manifestation is pain that can be localized to the occipital region or diffused to the whole skull, pulsating or strongly intensive, excruciating, monolateral with involvement of the ocular region and the occipital area. 5 Periodicity also represents a characteristic of the headache in addition to different durations of pain. Often, there are well-defined associated symptoms, such as lacrimation and irritation of the conjunctiva, nasal congestion, eye swelling, or pupil contraction, found especially in cluster headaches. The warning symptoms of pathological onset, like irritability, fatigue, and intolerance to noise, are characteristic of migraine that can degenerate even into blurred vision, alteration of sensitivity, and disorders of consciousness found in the most severe cases of migraine with aura. 6 The presence of attacks is variable depending on whether it is an episodic, chronic, or recurrent headache, and the duration may vary from half an hour to 1 hour, on two or three consecutive days. 7 Today there is no specific treatment for headaches, and sufferers often resort to empirical methods or self-medication. The agents available for the treatment of headaches are few and often have side effects such as sedation and nausea, which weaken, even if temporarily, so they cannot be used continuously. 8-10 Food-Headache Relationship The use of proper nutrition to prevent and alleviate the symptoms of headache is a practice the origins of which are very old. Hippocrates knew well the relationship between the ingestion of some substances and the onset of migraine for which many foods can be the main cause due to the

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Section: Phytotherapy and Headachementioning

confidence: 99%

Nutrition and Phytotherapy: A Winning Combination Against Headache

Ferrara

2019

Int J Med Rev

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“…Isolation of 4-phenylpropanoids from Australian species of C. ambiguus has been reported. These compounds are eugenol (4-allyl-2-methoxyphenol) (18); elemicin (5-allyl-1,2,3-trimethoxybenzene) (19); eugenol methylether (4-allyl-1,2-dimethoxybenzene) (20) and trans-iso-elemicin (1,2,3-trimethoxy-5-(1-propenyl) benzene) (21) and all these isolates exhibited good inhibition activity against ADP-induced human platelet serotonin release which is associated with headaches [26].…”

Section: Flavonoidsmentioning

confidence: 99%

“…In the literature, the majority of the C. citratus analysed showed a remarkably high percentage of neral (25) and geranial (26). Analysis of C. citratus species from Brazil [42], India [43], West and Eastern Africa [43][44][45][46][47][48][49] and Asia [50] showed the high value of neral and geranial chemotypes.…”

Section: Volatile Terpenoids Of Cymbopogon Speciesmentioning

confidence: 99%

Cymbopogon Species; Ethnopharmacology, Phytochemistry and the Pharmacological Importance

et al. 2015

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Abstract:Cymbopogon genus is a member of the family of Gramineae which are herbs known worldwide for their high essential oil content. They are widely distributed across all continents where they are used for various purposes. The commercial and medicinal uses of the various species of Cymbopogon are well documented. Ethnopharmacology evidence shows that they possess a wide array of properties that justifies their use for pest control, in cosmetics and as anti-inflammation agents. These plants may also hold promise as potent anti-tumor and chemopreventive drugs. The chemo-types from this genus have been used as biomarkers for their identification and classification. Pharmacological applications of Cymbopogon citratus are well exploited, though studies show that other species may also useful pharmaceutically. Hence this literature review intends to discuss these species and explore their potential economic importance.

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“…20 While the content of essential oils such as eugenol or elemicin can inhibit ADP-induced platelet aggregation. Eugenol also tend to have potential in the treatment of other diseases associated with platelet aggregation, such as thrombosis, transient ischemic, inflammatory, tumor growth and increased atherosclerosis, 6 and the antiplatelet action of saponins can inhibit the action of calcium ions because calcium ions work as a promoter vasoconstriction in blood vessel. 7 The platelet aggregation inhibitory assay is performed by calculating the percent aggregation of plasma absorbance before and after addition of ADP.…”

Section: 12mentioning

confidence: 99%

“…5 Grice et al (2010) proved that the content of essential oils like eugenol and elemycin had antiplatelet activity as they can inhibit adenosine diphosphate (ADP) induction during platelet aggregation process. 6 Meanwhile, Lee et al (2005) demonstrated that antiplatelet activity of saponin can inhibit the action of calcium ion as during platelet aggregation process calcium ion can promote vasoconstriction. 7 On the grounds of the aforementioned findings, the presence of the three compounds may inhibit the formation of platelet aggregation.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Lantana camara L., Eclipta prostrata (L.) L. and Cosmos caudatus Kunth. Leaf Extracts on ADP-Induced Platelet Aggregation

Sandhiutami¹,

Desmiaty²,

Noviyanti³

2018

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Objective:The leaves of Lantana camara L., Eclipta prostrata (L.) L. and Cosmos caudatus Kunth. are rich in flavonoids, saponins and essential oils. This study was carried out to determine the antiplatelet effect of the three plant extracts on ADP-induced platelet aggregation. Methods: The samples consisted of clopidogrel as positive control, aquadest as negative control and test extracts with concentrations of 40, 60, 80 and 100 mg/ml. Platelet Rich Plasma (PRP) was added for each extract concentration. The absorbance test of the samples was measured at 600 nm, before and after the addition of 20 μL adenosine diphosphate (ADP) 5 mM. After ADP added, then measured again the plasma absorbance was measured of the same wavelength. Antiplatelet aggregation activity was determined by calculating plasma absorbance before and after addition of ADP. Results: The results showed that the inhibitory percentage of platelet aggregation with extract concentrations of 100, 80, 60 and 40 mg/ml were Lantana camara L. leaf extract (91.17%; 73.27%; 72.86% and 37.15%), Eclipta prostrata (L.) L. leaf extract (74.55%; 65.60%; 48.00% dan 39.08%) and Cosmos caudatus Kunth. Leaf extract (59.17%; 52.56%; 14.25% dan 13.82%), respectively. The test extracts inhibited in vitro ADP-induced platelet aggregation with IC 50 value were as follows: 47.09 mg/ml (Lantana camara L), 59.02 mg/ml (Eclipta prostrata (L.) L.) and 87.26 mg/ml (Cosmos caudatus Kunth.) Conclusion: The present work demonstrated that the three extracts could inhibit in-vitro ADP-induced platelet aggregation and the best potency was shown by Lantana camara L leaf extract.

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Isolation of Bioactive Compounds That Relate to the Anti‐Platelet Activity of Cymbopogon ambiguus

Cited by 19 publications

References 72 publications

Nutrition and Phytotherapy: A Winning Combination Against Headache

Nutrition and Phytotherapy: A Winning Combination Against Headache

Cymbopogon Species; Ethnopharmacology, Phytochemistry and the Pharmacological Importance

Inhibitory Effect of Lantana camara L., Eclipta prostrata (L.) L. and Cosmos caudatus Kunth. Leaf Extracts on ADP-Induced Platelet Aggregation

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