Isolation of chemical compositions as dietary antioxidant supplements and neuroprotectants from Chaga mushroom (Inonotus obliquus)

Chang, Ye; Bai, Ming; Xue, Xiao-Bian; Zou, Chun-Xin; Huang, Xiao‐Xiao; Song, Shao‐Jiang

doi:10.1016/j.fbio.2022.101623

Cited by 20 publications

(6 citation statements)

References 52 publications

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“…Compounds ( 1a/1b–7 ) were evaluated for neuroprotective activities using the MTT method with Trolox as a positive control, which followed the previous methods. 31–33…”

Section: Methodsmentioning

confidence: 99%

Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling

et al. 2023

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“…Compounds ( 1a/1b–7 ) were evaluated for neuroprotective activities using the MTT method with Trolox as a positive control, which followed the previous methods. 31–33…”

Section: Methodsmentioning

confidence: 99%

Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling

et al. 2023

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“…After geometry optimization by DFT calculations, the conformers were selected in an energy window of 10 kcal/mol for further ECD calculation by Gaussian 09 . The ECD curves were simulated using SpecDis 1.51 software. , The molecular orbital analysis of 1 was performed by Multiwfn 3.8 and further evaluated with VMD 1.9.3 software. − …”

Section: Methodsmentioning

confidence: 99%

Highly Oxidized Germacranolides from Elephantopus tomentosus and the Configurational Revision of Some Previously Reported Analogues

Bai

et al. 2022

J. Nat. Prod.

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Highly oxidized germacranolides are mainly found in the genus Elephantopus, contain a characteristic ten-membered molecular core that is highly flexible, and exhibit potential cytotoxic properties. However, their configurations were assigned ambiguously in previous reports due to spectroscopic observation of macrocyclic systems. Herein, 17 highly oxidized germacranolides, including 12 new germacranolides (1−12), were isolated from Elephantopus tomentosus. Their structures were characterized by spectroscopic data analysis combined with X-ray crystallography and ECD calculations, and it was possible to propose configurational revisions of five previously reported analogues (13−17). Cytotoxic activities for 1−17 against two hepatocellular carcinoma cell lines (HepG2 and Hep3B) were tested, and compounds 1−10 and 13−16 generated IC 50 values of 2.2−9.8 μM. Furthermore, the observed cytotoxic activity of 1 was determined as being mediated by inducing the apoptosis of HepG2 and Hep3B cells via mitochondrial dysfunction.

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“…Through a comprehensive analysis of constituents separated from I. obliquus using DPPH, ABTS, and FRAP analysis, it was found that two compounds, phellxinye A ( 76 ) and inonotphenol A ( 49 ), have the strongest antioxidant activities (Chang et al 2022 ). Further electronic analysis of phellxinye A using the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) revealed potential active sites vital for the antioxidant properties of phellxinye A, including the isocoumarin fragment and cis double-bond present in the compound’s structure.…”

Section: Bioactive Compounds and Their Therapeutic Properties Of ...mentioning

confidence: 99%

Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review

Ern,

Quan,

Yee

et al. 2023

Mycology

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Inonotus obliquus , also known as Chaga, is a medicinal mushroom that has been used for therapeutic purposes since the sixteenth century. Collections of folk medicine record the application of Chaga for the treatment of diseases such as gastrointestinal cancer, diabetes, bacterial infection, and liver diseases. Modern research provides scientific evidence of the therapeutic properties of I. obliquus extracts, including anti-inflammatory, antioxidant, anticancer, anti-diabetic, anti-obesity, hepatoprotective, renoprotective, anti-fatigue, antibacterial, and antiviral activities. Various bioactive compounds, including polysaccharides, triterpenoids, polyphenols, and lignin metabolites have been found to be responsible for the health-benefiting properties of I. obliquus . Furthermore, some studies have elucidated the underlying mechanisms of the mushroom’s medicinal effects, revealing the compounds’ interactions with enzymes or proteins of important pathways. Thus, this review aims to explore available information on the therapeutic potentials of Inonotus obliquus for the development of an effective naturally sourced treatment option.

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Isolation of chemical compositions as dietary antioxidant supplements and neuroprotectants from Chaga mushroom (Inonotus obliquus)

Cited by 20 publications

References 52 publications

Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling

Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling

Highly Oxidized Germacranolides from Elephantopus tomentosus and the Configurational Revision of Some Previously Reported Analogues

Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review

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