2000
DOI: 10.1099/0022-1317-81-8-1927
|View full text |Cite
|
Sign up to set email alerts
|

Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus

Abstract: Since it was first described in Australia in 1994, Hendra virus (HeV) has caused two outbreaks of fatal disease in horses and humans, and an isolated fatal horse case. Our preliminary studies revealed a high prevalence of neutralizing antibodies to HeV in bats of the genus Pteropus, but it was unclear whether this was due to infection with HeV or a related virus. We developed the hypothesis that HeV excretion from bats might be related to the birthing process and we targeted the reproductive tract for virus is… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

11
474
1
7

Year Published

2008
2008
2016
2016

Publication Types

Select...
5
5

Relationship

0
10

Authors

Journals

citations
Cited by 608 publications
(493 citation statements)
references
References 15 publications
11
474
1
7
Order By: Relevance
“…The most likely route of HeV transmission to horses is through the ingestion of grass or partially eaten fruit contaminated with bat urine, saliva or other fluids. The coincidence of HeV outbreaks with birthing seasons of Australian fruit bat species (5) and the isolation of HeV from the uterine fluid and aborted foetus of a wild grey-headed fruit bat (P. poliocephalus, (7)) indicate that this may be a significant route of HeV infection for horses. We have recently demonstrated vertical transmission of NiV in experimentally infected cats further supporting this route as potentially an important natural route of tranmission (19).…”
Section: Introductionmentioning
confidence: 99%
“…The most likely route of HeV transmission to horses is through the ingestion of grass or partially eaten fruit contaminated with bat urine, saliva or other fluids. The coincidence of HeV outbreaks with birthing seasons of Australian fruit bat species (5) and the isolation of HeV from the uterine fluid and aborted foetus of a wild grey-headed fruit bat (P. poliocephalus, (7)) indicate that this may be a significant route of HeV infection for horses. We have recently demonstrated vertical transmission of NiV in experimentally infected cats further supporting this route as potentially an important natural route of tranmission (19).…”
Section: Introductionmentioning
confidence: 99%
“…All 14 outbreaks involved transmission of virus from flying foxes to a primary case horse, and five events involved subsequent transmission to humans resulting in an illness or death (see the electronic supplementary material, table S1). Experimentally infected flying foxes exhibit a short infectious period with no apparent clinical disease, and viral excretion in urine, saliva, faeces and placental fluids [19,20]. Transmission from flying foxes to horses is presumed to be via ingestion of pasture, feed or water contaminated with these products [13,21].…”
Section: Introductionmentioning
confidence: 99%
“…The virus was also detected in uterine fluid and foetal tissue, confirming Flying-foxes as the natural host. 7 Australian Flying-foxes live along much of the Australian coast ( Figure 1). Hendra virus infection could theoretically occur anywhere in Australia where there are Flying-foxes.…”
Section: Results Of Literature Reviewmentioning
confidence: 99%