Isolation ofN,N-Dimethyl andN-Methylserotonin 5-O-β-Glucosides from ImmatureZanthoxylum piperitumSeeds

Abstract

Two serotonin derivatives, N,N-dimethylserotonin 5-O-β-glucoside (1a) and N-methylserotonin 5-O-β-glucoside (1b) were isolated from immature seeds of Zanthoxylum piperitum. Their structures were determined by multi-step conversion reactions and spectroscopic analyses. Immature seeds of Z. piperitum contained extremely high levels of compounds 1a and 1b of approximately 0.29% and 0.15% (w/w), respectively.

Expression of IPT in Asakura-sanshoo (Zanthoxylum piperitum (L.) DC. f. inerme Makino) Alters Tree Architecture, Delays Leaf Senescence, and Changes Leaf Essential Oil Composition

“…Zanthoxylum piperitum DC., an important deciduous aromatic woody shrub in the Rutaceae, has been used for centuries as an important spice with a fresh flavor. It has also been used in China, Japan, and Korea as a traditional medicine to treat colds, vomiting, diarrhea, and hypotension (Epple et al 2001 ; Hwang 2005 ; Sun et al 2010 ; Yanase et al 2010 ). Essential oils of Z. piperitum show a wide spectrum of biological activities, including strong antimicrobial, insecticidal activities against test organisms, and antioxidant and anticancer activities (Kamsuk et al 2007 ; Kim et al 2003 ; Lee et al 1997 ; Lee and Lim 2008 ; Negi et al 2011 ).…”

Metabolism of Nω‐methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes

“…Even though the amount of N ω -MeSer in black cohosh is small, it is one of the few confirmed sources of human exposure to this potent serotonergic ligand. It has also been found in several species of Citrus plants and in glucosidated form, in immature seeds of Japanese pepper ( Zanthoxylum piperitum) (Servillo et al , 2013; Yanase et al , 2010). Our data from these studies with human microsomes indicate that metabolism of N ω -MeSer is essentially the same as that of serotonin.…”

International Service Learning among Islamic Higher Education Institution Challenges and Strategies

“…Language barriers are the most obvious challenges encountered by the participants of ISL. According to Baker-Boosamra et al (2006b), "The language barrier is an issue for both students and community members, but not a big problem," Further, it is stated that, "without at least a beginner's proficiency in the local language, students are unable to provide much care without the help of an interpreter (Reisch, 2011). "…”