Isolation of Nipah virus from Malaysian Island flying-foxes

Chua, Kaw Bing; Koh, Chong Lek; Hooi, Poh Sim; Wee, Kong Fatt; Khong, Jenn Hui; Chua, Beng Hooi; Chan, Yee Peng; Lim, Mou Eng; Lam, Sai Kit

doi:10.1016/s1286-4579(01)01522-2

Cited by 539 publications

(486 citation statements)

References 15 publications

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“…NiV was isolated from fruit bats in Malaysia [16] Fruit bats with antibodies to NiV were captured in the outbreak areas of Bangladesh but no intermediate animal host was identified. In Bangladesh, NiV might have been transmitted to humans by direct contact with bats or indirectly by contact with material contaminated by bats.…”

Section: Nipah Virus Infection 399mentioning

confidence: 99%

Nipah virus infection: current scenario

et al. 2013

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Section: Nipah Virus Infection 399mentioning

confidence: 99%

Nipah virus infection: current scenario

et al. 2013

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“…Viral transmission from bats to intermediate hosts via partially eaten fruit has been posited for both NiV (4) and HeV (5) and NiV has been isolated from a swab of partially eaten fruit in the wild (4). Therefore, the survival of henipaviruses on fruit flesh and in fruit juice was examined.…”

Section: Virus Survival In Fruit Juice and Fleshmentioning

confidence: 99%

Henipavirus susceptibility to environmental variables

et al. 2008

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The routes of henipavirus transmission between hosts are poorly understood. The purpose of this study was to measure the persistence of henipaviruses under various environmental conditions and thereby gain an insight into likely mechanisms of transmission. Henipaviruses survived for more than four days at 22°C in pH-neutral fruit bat urine but were sensitive to higher temperatures and pH changes. On mango flesh, survival time varied depending on temperature and fruit pH, ranging from two hours to more than two days. Desiccation of viruses substantially reduced survival time to less than two hours. The sensitivity of henipaviruses to pH, temperature and desiccation indicates a need for close contact between hosts for transmission to occur, although under ideal conditions henipaviruses can persist for extended periods facilitating vehicle-borne transmission.

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“…[5][6][7][8] The natural host is very likely to be the fruit bat because NiV has been isolated from bat's urine. 9 Thus, the NiV outbreak represents the most serious viral zoonosis that has emerged from bats recently. 10 Based on studies of NiV-infected human tissues, the pathology and pathogenesis of NiV infection is beginning to be understood.…”

mentioning

confidence: 99%

A Golden Hamster Model for Human Acute Nipah Virus Infection

Wong

Grosjean

Brisson

et al. 2003

The American Journal of Pathology

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A predominantly pig-to-human zoonotic infection caused by the novel Nipah virus emerged recently to cause severe morbidity and mortality in both animals and man. Human autopsy studies showed the pathogenesis to be related to systemic vasculitis that led to widespread thrombotic occlusion and microinfarction in most major organs especially in the central nervous system. There was also evidence of extravascular parenchymal infection, particularly near damaged vessels A recent outbreak of a novel paramyxovirus subsequently named Nipah virus (NiV) infected hundreds of patients in Malaysia causing severe morbidity and a mortality rate of ϳ40%.

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Isolation of Nipah virus from Malaysian Island flying-foxes

Cited by 539 publications

References 15 publications

Nipah virus infection: current scenario

Nipah virus infection: current scenario

Henipavirus susceptibility to environmental variables

A Golden Hamster Model for Human Acute Nipah Virus Infection

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