Isoprinosine versus other antiviral drugs for chronic hepatitis B

Njei, Basile; Garg, Sushil Kumar; Kenta-Bibi, Emmanuel; Zhao, Pan; Kongnyuy, Eugene J

doi:10.1002/14651858.cd010506

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Drink and feed additives as immune enhancers are of particular concern in this respect [1] Inosine Acedoben Dimepranol (IAD, Isoprenosine ® ) is a synthetic purine derivative, composed of the pacetamidobenzoate salt of N, N-dimethylamino-2-propanol and inosine at a 3:1 molar ratio which provides a unique double therapeutic benefits. Namely, it exerts antiviral effects [2] and immunomodulatory activities [3], on the other hand. It also used for treatment of Leishmania major infection, multiple sclerosis, Echinococcus multilocularis and Echinococcus granulosus metacestodes, neurodegeneration, cancer and alopecia [4].…”

Section: Introductionmentioning

confidence: 99%

Biochemical study on immunomodulation and safety margin of inosine acedoben dimepranol before and after vaccination

2019

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The aim of this study was to evaluate the immunopotentiating effect of IAD in broiler chickens either vaccinated or unvaccinated and to evaluate the safety profile of IAD after treatment with escalating doses. To assess the immunological effect of IAD, eighty chicks were used and divided into four groups. First group kept as control group, second received Isoprinosine (16.3 mg/kg, day after day), third received a routine New Castle disease virus vaccine and the last group received both treatments of Isoprinosine and ND vaccine. The second part of the study aimed to evaluate the safety profile of IAD, to achieve this aim eighty chicks were used, divided equally and given different concentration of IAD 8.15, 16.3, 32.6 mg/kg day after day repetitively. We concluded that, IAD enhanced both nonspecific and specific immune responses in broiler chicken, especially in vaccinated ones, in terms of increased antibody and decreased NDV titers, indicated by HI and PCR, respectively. Also, IAD showed dose-dependent good safety profile, including blood picture, organ function profile and metabolic parameters, indicated by biochemical analyses.

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Section: Introductionmentioning

confidence: 99%