Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.

González-Cortazar, Manasés; Maldonado-Abarca, Ana María; Jiménez-Ferrer, Enrique; Marquina, Silvia; Ventura-Zapata, Elsa; Zamilpa, Alejandro; Tortoriello, Jaime; Herrera-Ruíz, Maribel

doi:10.3390/molecules181113260

Cited by 22 publications

(11 citation statements)

References 18 publications

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“…This is in agreement with previous reports regarding the involvement of serotonergic brain systems on antidepressant-like effect of other Salvia species extracts i.e. S. elegans and S. verticillata (15,39,41,42). In addition, salvinorin A, a major active compound of S. divinorum extract, has also exhibited antidepressant-like effect by reduced immobility and enhanced swimming behaviors in the FST (17), which is suggestive of serotonergic involvement similar to the S. macrosiphon extract.…”

Section: Discussionsupporting

confidence: 92%

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

et al. 2019

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Objectives: As some species of the Salvia family have been shown to exert antidepressant-like activity, the aim of this study was to investigate the antidepressant effects of the aqueous and hydroalcoholic extracts of Salvia mirzayanii and Salvia macrosiphon, two endemic species of salvia in Iran. Methods: In total, 148 eight-week-old male albino mice (25-35 g) were used to carry out the forced swimming test. The effects of different doses of the aqueous (100-1800 mg/kg) and hydroalcoholic extracts (75-900 mg/kg) of Salvia mirzayanii and Salvia macrosiphon on immobility, climbing, and swimming behaviors were examined. Fluoxetine and imipramine were used as control drugs. The effects of extracts on locomotor activity were also evaluated. Results: High doses of the aqueous extracts of both plants and hydroalcoholic extract of Salvia mirzayanii produced a significant reduction in immobility and increase in swimming compared to the control group. The hydroalcoholic extract of Salvia macrosiphon did not show any significant effect on immobility and swimming. Only some doses of hydroalcoholic extract of Salvia mirzayanii and aqueous extract of Salvia macrosiphon showed a significant increase in climbing behavior. The aqueous and hydroalcoholic extract of both plants caused a decrease in spontaneous activity. Conclusions: The findings of this study indicated that the aqueous and hydroalcoholic extracts of Salvia mirzayanii and the aqueous extract of Salvia macrosiphon had antidepressant-like activity. In addition, the hydroalcoholic extract of Salvia mirzayanii and the aqueous extracts of Salvia macrosiphon were more effective fractions of these plants. These endemic Iranian Salvia species may have potential therapeutic effects for depression.

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Section: Discussionsupporting

confidence: 92%

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

et al. 2019

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“…In addition, total sterols and β-sitosterol significantly increased 5-HIAA levels, indicating a reduced 5-HT metabolism. Enhancing 5-HT and/or NE neurotransmission is currently the most efficacious treatment for depression [ 31 , 32 , 33 ]. Our findings suggest that the antidepressant-like effect of total sterols and β-sitosterol are likely mediated through increased 5-HT and NE levels in the central nervous system.…”

Section: Resultsmentioning

confidence: 99%

Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri

Zhao

Zheng

et al. 2016

Marine Drugs

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The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitosterol was administered intraperitoneally at doses of 10, 20, and 30 mg/kg. β-sitosterol had no effect on locomotor activity in the open field test. In addition, total sterols and β-sitosterol significantly increased NE, 5-HT, and the metabolite 5-HIAA in the mouse brain, suggesting that the antidepressant-like activity may be mediated through these neurotransmitters.

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“…In the pre-test session, each animal was subjected to the forced swim for 15 min, 24 h before the test, and during the test session, immobility time was recorded [43]. It was suggested that immobility reflects a state of lowered mood in which the animals have given up hope of finding an exit and have resigned themselves to the experimental situation [44].…”

Section: Methodsmentioning

confidence: 99%

In Vivo Gastroprotective and Antidepressant Effects of Iridoids, Verbascoside and Tenuifloroside from Castilleja tenuiflora Benth

et al. 2019

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Stress is an important factor in the etiology of some illnesses such as gastric ulcers and depression. Castilleja tenuiflora Benth. (Orobanchaceae) is used in Mexican traditional medicine for the treatment of gastrointestinal diseases and nervous disorders. Previous studies indicated that organic extracts from C. tenuiflora had gastroprotective effects and antidepressant activity. In this study, we aimed to evaluate the gastroprotective and antidepressant activity of fractions and isolated compounds from the methanolic extract (MECt) of C. tenuiflora in stressed mice. Chromatographic fractionation of MECt produced four fractions (FCt-1, FCt-2, CFt-3, and FCt-4) as well as four bioactive compounds which were identified using TLC, HPLC and NMR analyses. The cold restraint stress (CRS)-induced gastric ulcer model followed by the tail suspension test and the forced swim test were used to evaluate the gastroprotective effect and antidepressant activity of the extract fractions. FCt-2 and FCt-3 at 100 mg/kg had significant gastroprotective and antidepressant effects. All isolated compounds (verbascoside, teniufloroside and mixture geniposide/ musseanoside) displayed gastroprotective effects and antidepressant activity at 1 or 2 mg/kg. The above results allow us to conclude that these polyphenols and iridoids from C. tenuiflora are responsible for the gastroprotective and antidepressant effects.

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Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.

Cited by 22 publications

References 18 publications

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

Antidepressant Effects of the Aqueous and Hydroalcoholic Extracts of Salvia mirzayanii and Salvia macrosiphon in Male Mice

Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri

In Vivo Gastroprotective and Antidepressant Effects of Iridoids, Verbascoside and Tenuifloroside from Castilleja tenuiflora Benth

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