Isotonic Solutions. II. The Permeability of Red Corpuscles to Various Substances**From the Department of Pharmacy, University of Florida, Gainesville, Fla.††This paper is based on a thesis presented to the Graduate Council of the University of Florida by James Richard Adams, in partial fulfillment of the requirements for the degree of Master of Science in Pharmacy.

0 A supplemental table of NaCl equivalents and freezing point depressions at various concentrations for 30 different medicinal substances in aqueous solution is presented. Also given in the table is the isosmotic concentration of each of the materials which can form a solution. The degree of hemolysis of human erythrocytes was determined in 63 different isosmotic solutions and the data are presented in a table to supplement the previously published values.Freezing point depression graphs for two substances-fluphenazine dihydrochloride and methotrimeprazine hydrochloride-are presented because they showed discontinuities caused by some type of association or aggregation in their solutions.Keyphrases 0 Sodium chloride equivalents-drugs 0 Cryoscopic properties4rugs 0 Hemolytic effects-drugs 0 Colorimetric analysis-hemolysis determination

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Cited by 13 publications

References 5 publications

In vitro hemolysis: Guidance for the pharmaceutical scientist

In vitro hemolysis: Guidance for the pharmaceutical scientist

Sodium Chloride Equivalents, Cryoscopic Properties, and Hemolytic Effects of Certain Medicinals in Aqueous Solution

Sodium Chloride Equivalents, Cryoscopic Properties, and Hemolytic Effects of Certain Medicinals in Aqueous Solution II: Supplemental Values

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