Sodium Chloride Equivalents, Cryoscopic Properties, and Hemolytic Effects of Certain Medicinals in Aqueous Solution

Potentiometric determination of dissociation constants

“…tion coefficient for most drugs using the pharmaceutical data far sodium chloride equivalents and cryoscopic properties (58)(59)(60) and isopiestic measurements (61) available for almost all acidic and basic drugs in use. One of us is presently examining the reliability of specific ion-interaction coefficients determined from the above-cited data (62).…”

Sodium Chloride Equivalents, Cryoscopic Properties, and Hemolytic Effects of Certain Medicinals in Aqueous Solution III: Supplemental Values

“…These critical concentrations can be determined readily from the abrupt change in their cryoscopic graphs (3,4,9). These critical concentrations can be determined readily from the abrupt change in their cryoscopic graphs (3,4,9).…”

“…The method, utilizing a 45-min incubation period of erythrocytes in the isosmotic solution followed by centrifugation of the erythrocytes and ghosts and determination of absorbance versus a standard at 520 nm in a colorimeter, was reported previously in detail (3)(4)(5). The method, utilizing a 45-min incubation period of erythrocytes in the isosmotic solution followed by centrifugation of the erythrocytes and ghosts and determination of absorbance versus a standard at 520 nm in a colorimeter, was reported previously in detail (3)(4)(5).…”

Sodium Chloride Equivalents, Cryoscopic Properties, and Hemolytic Effects of Certain Medicinals in Aqueous Solution IV: Supplemental Values

“…The sodium chloride equivalents and freezing-point depressions for 499 substances in aqueous solution were determined experimentally and reported previously (1)(2)(3)(4)(5). Furthermore, the degree of hemolysis of fresh human hemolytic investigations.…”

“…Sodium equivalents-data for 29 drugs CrYOSCOPiC properties-data for 29 drugs 0 Hemolytic effects-data for 29 drugs 0 Medicinals-sodium chloride equivalents, cryoscopic properties, and hemolytic effects determined for 29 drugs erythrocytes in certain aqueous isosmotic solutions was studied using the hemolytic method (3)(4)(5)(6).…”