Isotopic analysis of platinum from single nanoparticles using a high-time resolution multiple collector Inductively Coupled Plasma - Mass Spectroscopy

Quantification and classification of engineered, incidental, and natural cerium-containing particles by spICP-TOFMS

“…By plotting data in terms of counts, we can directly compare measured results to that predicted by Poisson statistics. 46 Poisson statistics, used for counting methods in set intervals, describes how to predict the probability of event occurrence as a function of the mean count rate ( λ ). As seen in Fig.…”

Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events

“…84,85 One limitation to such approach (besides the fact that some relevant elements, such as Au, are mono-isotopic) is that, when a non-simultaneous ICP-MS is deployed, the analyte isotopes are not really measured from the same NPs. Very recently, the use of an ICP-TOF-MS device for this purpose has been reported, discussing also the modest precision that characterizes this approach when targeting NPs (owing to low count statistics, as also reported for multicollector ICP-MS instrumentation) 86 and the effect of the concentration of the spike on the results. 87 The use of other strategies, such as internal standardization, are also affected by the sequential character of the monitoring.…”

Towards Automated and High-Throughput Quantitative Sizing and Isotopic Analysis of Nanoparticles via Single Particle-ICP-TOF-MS

“…Typically, this measurement would require the ability to simultaneously measure multiple isotopes of interest, such that single particle discrimination can be achieved. To date, and the authors' knowledge, SP-ICP-MS of suspension for isotopic determination has only been primarily investigated with either a TOF [25,31] or SF-MC [25,[32][33][34] configuration, albeit a recent study demonstrated the effectiveness of a quadrupole-based ICP with the employment of O 2 gas for transient broadening [23]. A recent study by Yin et al, explored the various ICP-based platforms to assess the figures of merit regarding isotope ratio measurements on single NPs and cells [25].…”