Isotype distribution of anti-Ro/SS-A and anti-La/SS-B antibodies in plasma and saliva of patients with Sjögren's syndrome

Wah, None A.-K Halse, M.C Marthinussen, M

doi:10.1080/030097400750001752

Cited by 38 publications

(5 citation statements)

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“…Immunoglobulins, including IgA, IgG, and IgM, account for 5–15% of total salivary proteins [ 16 , 17 ]. However, variable salivary concentrations have been reported for each isotype [ 23 , 31 – 33 ]. Although IgG is the dominant immunoglobulin in serum, IgA comprises > 85% of salivary immunoglobulins [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus

Zhang

et al. 2022

Arthritis Res Ther

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Objectives To assay salivary anti-nuclear antibody (ANA) and its isotypes in patients with systemic lupus erythematosus (SLE) and to investigate relevant clinical associations. Methods Saliva samples were collected from SLE patients and assayed for salivary ANA using immunofluorescence (IF). Isotypes of salivary ANA, including IgG-ANA, IgA-ANA, and IgM-ANA, were quantified using enzyme-linked immunosorbent assay. The correlations between clinical parameters and levels of salivary ANA and isotypes were evaluated. Results Salivary ANA IF intensities were significantly higher in SLE patients than in healthy controls, irrespective of SLE patient disease activity, and strongly correlated with serum ANA titers. Salivary ANA was detected in 67.14% of SLE patients and 10.00% of healthy controls (p < 0.001). Among ANA-positive samples, 80.85% exhibited a nuclear ANA pattern, and 42.55% exhibited a cytoplasmic ANA pattern. Salivary IgG-ANA, IgA-ANA, and IgM-ANA levels, as assayed by ELISA, were significantly increased in both active and less active SLE patients compared with healthy controls, and levels of each isotype were significantly correlated with serum ANA titer. Salivary IgM-ANA levels correlated with the physician global assessment (PGA), SLE disease activity index (SLEDAI), and negatively with serum C3 and C4. Salivary IgG-ANA also correlated with erythrocyte sedimentation rate (ESR), SLEDAI, and negatively with serum C3. Conclusion Salivary ANA levels correlate with serum ANA titer, and salivary IgM-ANA and IgG-ANA correlate variably with PGA, SLEDAI, ESR and complement levels. These findings underscore the potential of using salivary ANA and ANA isotypes as surrogates for serum ANA, particularly for future point-of-care applications since saliva is easier to obtain than blood.

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Section: Discussionmentioning

confidence: 99%

Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus

Zhang

et al. 2022

Arthritis Res Ther

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“…3 4 The presence of autoantibodies in serum targeting the Ro/SSA and La/SSB antigens demarks a patient subset with distinct major histocompatibility complex genotypes, whereas genetic features in patients with pSS without these autoantibodies have not been demonstrated to significantly differ from that of controls. [5][6][7][8] Treatment of pSS is mainly symptomatic since evidence-based treatment with a significant impact on the disease course is currently lacking. 3 Also, knowledge on factors suitable for preventive measures is insufficient.…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoking patterns preceding primary Sjögren’s syndrome

et al. 2020

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BackgroundCigarette smoking is a well-established risk factor for several autoimmune diseases, but its role in primary Sjögren’s syndrome (pSS) remains unclear. Here, we investigated the association between cigarette smoking and subsequent development of pSS.MethodsInformation on smoking habits was collected from lifestyle habit questionnaires of patients with pSS (n=815) and a matched control group (n=4425) for a case–control study. Differences in smoking exposure were analysed by conditional logistic regression. Potential interactions between smoking and risk-associated human leucocyte antigens (HLA) were assessed by multivariate regression.ResultsThe fraction of patients with pSS having ever smoked prior to diagnosis was lower than in controls (OR 0.67, 95% CI 0.55 to 0.81). Current smoking at diagnosis was also less prevalent in cases (OR 0.37, 95% CI 0.26 to 0.53). However, period prevalence of smoking during early adulthood was not statistically different from controls (OR 0.89, 95% CI 0.66 to 1.22) but markedly decreased over time. This was partly due to patients being more prone to stop smoking, starting already 30 years prior to diagnosis (OR 2.01, 95% CI 1.22 to 3.30). Smoking patterns were also stratified by autoantibody status, yielding similar estimates. No interaction effects between HLA-DRB1 haplotypes and smoking were observed.ConclusionThe observed smoking patterns indicate that individuals who develop pSS smoke equally much as the general population during early life but are then more prone to stop. The data can be interpreted as smoking conferring protective effects, or reflecting early symptoms of pSS that affect smoking habits, emphasising the slow, progressive development of the disease.

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“…However, the distribution of IgG antibodies against exocrine glands M 3 and M 1 mAChRs was found to correlate well with SS disease activity (Bacman et al, 1996(Bacman et al, , 1998(Bacman et al, , 2001Perez Leiros et al, 2002). Moreover, the titer of antibodies of IgA subclass also correlated with SS disease activity (Anaya and Talal, 1997;Halse et al, 2000). Berra et al (2002) demonstrated high prevalence of saliva IgA with mAChR activity in SS patients.…”

Section: Introductionmentioning

confidence: 99%

Autoantibodies against cerebral muscarinic cholinoceptors in Sjögren syndrome: functional and pathological implications

Reina

Sterin‐Borda

Orman

et al. 2004

Journal of Neuroimmunology

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Isotype distribution of anti-Ro/SS-A and anti-La/SS-B antibodies in plasma and saliva of patients with Sjögren's syndrome

Cited by 38 publications

References 20 publications

Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus

Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus

Cigarette smoking patterns preceding primary Sjögren’s syndrome

Autoantibodies against cerebral muscarinic cholinoceptors in Sjögren syndrome: functional and pathological implications

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