It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

Farrera, Consol; Fadeel, Bengt

doi:10.1016/j.ejpb.2015.03.007

Cited by 93 publications

(69 citation statements)

References 105 publications

(126 reference statements)

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“…This implicates that the reported effects of NPs are therefore dependent on the context or experimental conditions. Although it is still not clear if NPs enter the cell by specific receptors, they can be considered as NAMPs (nanoparticle-associated molecular patterns) by analogy to DAMPs and PAMPs, danger-and pathogen-associated molecular patterns, respectively [45,46]. In agreement with this, we recently reported that, in human mononuclear cells, silver nanoparticles induced pyroptosis and activation of the NLRP-3 inflammasome, as demonstrated by the processing and increased activity of caspase-1, secretion of IL-1β and ASC (apoptosis-associated speck-like protein containing a CARD domain) pyroptosome formation [47].…”

Section: Discussionmentioning

confidence: 99%

Nanoparticles enhance the ability of human neutrophils to exert phagocytosis by a Syk-dependent mechanism

Babin

Gonçalves

Girard

2015

Biochimica et Biophysica Acta (BBA) - General Subjects

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Section: Discussionmentioning

confidence: 99%

Nanoparticles enhance the ability of human neutrophils to exert phagocytosis by a Syk-dependent mechanism

Babin

Gonçalves

Girard

2015

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Recently, studies by Jones et al demonstrated that experimental mouse that is prone to Th1 immune response cleared introduced nanoparticles at a slower rate than rats prone to Th2 [96]. In the human sense of application, the study showed that the nature or status of the human immune system can determine how the body can clear nanoparticles when introduced into the body [94].…”

Section: Nanomaterials Interaction With the Innate Immune Systemmentioning

confidence: 99%

“…Farrera and Fadeel had proposed, during the study of the relationship between the immune system and engineered nanomaterials, that most, if not all, of the adverse effects of engineered nanomaterials are exerted through direct effects on the cells of the innate system. The cells implicated here were listed as the dendritic cells (DCs), the macrophages, the phagocytes, and the antigen-presenting cells [94]. A brief review of the interaction of nanomaterials with the two recognized human immune systems is carried out here for a better understanding of the interaction because it takes two to tango [94].…”

Section: The Interaction Between Nanomaterials and The Human Immune Smentioning

confidence: 99%

“…The cells implicated here were listed as the dendritic cells (DCs), the macrophages, the phagocytes, and the antigen-presenting cells [94]. A brief review of the interaction of nanomaterials with the two recognized human immune systems is carried out here for a better understanding of the interaction because it takes two to tango [94].…”

Section: The Interaction Between Nanomaterials and The Human Immune Smentioning

confidence: 99%

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Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

Ukaegbu

Jalal²,

Rashid³

et al. 2017

Asian J Pharm Clin Res

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The pharmacological potential of bioactive compounds extracted from mushrooms has been studied to a reasonable level. In the same vein, the bioactivity of nanoparticles has also been investigated and reported to be of potential pharmacological benefit. No doubt, there is a reasonable amount of claims regarding the vast activity of the mushroom extracts and nanoparticles on the tested cell lines and microorganisms. In this paper, a review of the recent application of bioactive compounds extracted from two edible mushrooms (Coprinus comatus and Lactarius deliciosus), as well as some of the recently reported studies on some nanoparticles of pharmacological potentials, was carried out. In order to check for synergy in the bioactivity of the mushroom extracts when co-administered with nanoparticles, an investigation on the synergistic application of the materials through the encapsulation of the bioactive extracts from the mushroom onto the nanoparticle was proposed. The supposed synergy in the activity of the extract-nanoparticle complex could hold the key to improved activity of nutraceuticals against resistant microorganisms and tumor cells.

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“…Systemically available NMPs have the tendency to end up in lymphoid organs, such as the spleen, 12,13 and interactions of NMPs and NM with the immune system play a leading role in the intensity and extent of side effects occurring simultaneously with the therapeutic activity. 14 The immune system is the body's defense against the invasion of foreign material and is also responsible for maintaining the body's homeostasis. Many adverse immune effects were reported after conventional medicinal product administration, including allergy, anaphylaxis, hypersensitivity, and immunosuppression.…”

mentioning

confidence: 99%

A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements

Giannakou¹,

Park²,

Jong³

et al. 2016

IJN

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Nanomaterials (NMs) are attractive for biomedical and pharmaceutical applications because of their unique physicochemical and biological properties. A major application area of NMs is drug delivery. Many nanomedicinal products (NMPs) currently on the market or in clinical trials are most often based on liposomal products or polymer conjugates. NMPs can be designed to target specific tissues, eg, tumors. In virtually all cases, NMPs will eventually reach the immune system. It has been shown that most NMs end up in organs of the mononuclear phagocytic system, notably liver and spleen. Adverse immune effects, including allergy, hypersensitivity, and immunosuppression, have been reported after NMP administration. Interactions of NMPs with the immune system may therefore constitute important side effects. Currently, no regulatory documents are specifically dedicated to evaluate the immunotoxicity of NMs or NMPs. Their immunotoxicity assessment is performed based on existing guidelines for conventional substances or medicinal products. Due to the unique properties of NMPs when compared with conventional medicinal products, it is uncertain whether the currently prescribed set of tests provides sufficient information for an adequate evaluation of potential immunotoxicity of NMPs. The aim of this study was therefore, to compare the current regulatory immunotoxicity testing requirements with the accumulating knowledge on immunotoxic effects of NMPs in order to identify potential gaps in the safety assessment. This comparison showed that immunotoxic effects, such as complement activation-related pseudoallergy, myelosuppression, inflammasome activation, and hypersensitivity, are not readily detected by using current testing guidelines. Immunotoxicity of NMPs would be more accurately evaluated by an expanded testing strategy that is equipped to stratify applicable testing for the various types of NMPs.

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It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

Cited by 93 publications

References 105 publications

Nanoparticles enhance the ability of human neutrophils to exert phagocytosis by a Syk-dependent mechanism

Nanoparticles enhance the ability of human neutrophils to exert phagocytosis by a Syk-dependent mechanism

Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements

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