IV. Weitere Beiträge zur Lehre von der Immunität und Überempfindlichkeit bei Trichophytieerkrankungen

Circulating Antibodies in Dermatophytosis

“…This fact may explain why some in vestigators [9,12,13] were unable to detect circulating antibodies in sera from patients with dermatophytic infection. The time in the course of the infection at which blood is taken is, therefore, of utmost importance for the study of circulating antibodies.…”

Immunology of Surface Fungi Dermatophytes

“…In contrast to Bloch's findings, most of the results of subsequent investigations on immunity in guinea pigs have indicated that immunity is complete or greatest only at the site of previous infection, while generalized immunity is of a lower grade (Sutter, 1917;Greenbaum, 1924;Kogoj, 1926;DeLamater and Benham, 1938b;Bonk et al, 1962). Kielstein (1968) and Lepper (1972) reported the development of a generalized resistance to reinfection in cattle following a primary experimental infection.…”

“…Other investigators could demonstrate a strong local immunity, only at the previously infected site following experimental infections of the smooth skin with zoophilic species (Sutter, 1917;Greenbaum, 1924;Epstein and Griinmandel, 1930).…”

Role of Keratinases in Dermatophytosis

“…Compared to man, the guinea pig develops a low level of sensitivity during dermatophytosis [3], High concentrations of antigen are, therefore, required to elicit the hypersensitivity reactions. The lower migration indices obtained with peritoneal exudate cells from some noninfected guinea pigs incubated with the keratinases may be due to nonspecific effects of the high antigen concentration used or, more likely, due to biological variability inherent in the technique.…”

“…They were infected cutaneously on the flank of the leg with spore suspensions (guinea pigs No. [1][2][3][4] or at the nape of the neck with mycelium (guinea pigs No. 5-8).…”