Ixazomib Treatment of IgA Multiple Myeloma With Hyperviscosity Syndrome

Hyperviscosity syndrome (HVS) is defined as the symptomatic presentation of increased blood thickness due to various clinical conditions such as hypergammaglobulinemia. HVS secondary to immunoglobulin (Ig)A multiple myeloma has been infrequently reported. Although the efficiency of IgM or IgG removal by therapeutic plasma exchange (TPE) is well described, the efficiency of IgA removal by TPE is not as well known. Here, we describe a case of HVS due to IgA myeloma in a patient who received 2 TPE treatments, with subsequent symptomatic improvement as well as decrease in IgA and viscosity levels.

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Ixazomib Treatment of IgA Multiple Myeloma With Hyperviscosity Syndrome

Cited by 5 publications

References 31 publications

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Therapeutic plasma exchange for hyperviscosity syndrome in IgA multiple myeloma

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