Jaboticaba (<i>Myrciaria cauliflora</i>) Peel Supplementation Prevents Hepatic Steatosis Through Hypolipidemic Effects and Cholesterol Metabolism Modulation in Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model

Lage, Nara Nunes; Carvalho, Mayara Medeiros de Freitas; Guerra, Joyce Ferreira da Costa; Lopes, Juliana Márcia Macedo; Pereira, Renata Rebeca; Rabêlo, Ana Carolina Silveira; Arruda, Vinícius Marques; Pereira, Mariana de Fátima Albuquerque; Layosa, Marjorie Anne; Noratto, Giuliana; Lima, Wanderson Geraldo de; Silva, Marcelo Eustáquio; Pedrosa, Maria Lúcia

doi:10.1089/jmf.2020.0141

Cited by 8 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2 , 17 The presence of hepatic steatosis and injury has previously been reported in HCD-induced hypercholesterolemic animals. 35 , 40 , 41 This is in accordance with our finding, which demonstrated that HCD consumption could induce hepatic steatosis in rats. However, daily administration of wax apple to hypercholesterolemic rats decreased hepatic lipid content, liver weight, and liver to body weight ratio.…”

Section: Discussionsupporting

confidence: 92%

Wax apple (Syzygium samarangense) fruit extract ameliorates endothelial dysfunction and liver damage in high cholesterol diet-fed rats

Prommaouan

Nernpermpisooth

Pengnet

et al. 2022

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Wax apple (Syzygium samarangense) fruit extract ameliorates endothelial dysfunction and liver damage in high cholesterol diet-fed rats

Prommaouan

Nernpermpisooth

Pengnet

et al. 2022

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

“…Another study investigated the effects of 4 % jaboticaba ( Myrciaria cauliflora ) peel powder supplementation on cholesterol metabolism and hepatic steatosis of rats with high-fat diets ( 46 ). In agreement with what was observed in this study, the authors of the study with jaboticaba observed an increase in lipid excretion in the faeces, improvement in the serum lipid profile, reduction in serum total cholesterol concentration, reduction in serum AST activity and attenuation of hepatic steatosis.…”

Section: Resultsmentioning

confidence: 99%

“…In agreement with what was observed in this study, the authors of the study with jaboticaba observed an increase in lipid excretion in the faeces, improvement in the serum lipid profile, reduction in serum total cholesterol concentration, reduction in serum AST activity and attenuation of hepatic steatosis. These effects were suggested to be related to the presence of fibre and phenolic compounds in the powder supplementation ( 46 ).…”

Section: Resultsmentioning

confidence: 99%

Effects of Banana (Musa spp.) Bract Flour on Rats Fed High-Calorie Diet

Ferreira

Santos

Almeida

et al. 2023

Food Technol. Biotechnol. (Online)

View full text Add to dashboard Cite

Research background: The extensive cultivation of bananas (Musa sp.) is related to producing tons of residues, such as leaves, pseudostems, and bracts (inflorescences). The banana bract is a commercially interesting residue due to its dietary fiber content and high antioxidant potential. In this scenario, this study evaluated the effects of administering banana bract flour in animal models fed a cafeteria diet. Experimental approach: Thirty-two male rats were segmented into 4 groups: 1) control diet, 2) control diet with 10 % banana bract flour, 3) hypercaloric diet, and 4) hypercaloric diet with 10 % bract flour of banana. The study was conducted for 12 weeks and included analysis of phenolic compounds, assessment of the antioxidant effect of banana bract flour, determination of serum biochemical parameters (glucose, total cholesterol, triglycerides, AST, ALT, amylase albumin, uric acid, creatine, total protein, and oral glucose), determination of faecal fat content, and histomorphological analysis of the liver, pancreas, and adipose tissue. In addition, molecular parameters such as IL6, total and phosphorylated JNK, total and phosphorylated IKKβ, TNFα, TLR4, and HSP70 were determined. Results and conclusions: The banana bract flour showed a high content of phenolic compounds and an antioxidant effect. The in vivo results suggest that the supplementation of a hypercaloric diet with banana bract flour prevented pathological damage by reducing total cholesterol and glucose levels, which may imply a hepatoprotective effect of this supplement. Thus, using banana bract flour as a supplement can increase the consumption of fiber, antioxidants, and bioactive compounds. Novelty and scientific contribution: The development of flour from banana waste and its inclusion in the diet can prevent and/or help treat obesity. In addition, banana bracts can be used to protect the environment, as they are considered a source of waste by the food industry.

show abstract

“…It is well known that the increased level of serum cholesterol or lipid profiles can promote atherosclerosis and other cardiovascular diseases [ 18 ]. An excess of cholesterol is used in most research to cause rapid hypercholesterolemia and atherosclerosis [ 19 ]. Traditional strategies for regulating hypercholesterolemia either decrease in bad cholesterol, i.e., LDL-cholesterol, or increase in good cholesterol, i.e., HDL-cholesterol [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

The Hypolipidemic and Antioxidant Activity of Wheat Germ and Wheat Germ Protein in High-Fat Diet-Induced Rats

Liu

Sun

Yang³

et al. 2022

Molecules

View full text Add to dashboard Cite

Background: So far, no articles have discussed the hypolipidemic effect of wheat germ protein in in vivo experiments. Objective: In this study, we investigated the effects of wheat germ protein (WGP, 300 mg/kg/day) and wheat germ (WG, 300 mg/kg/day) on cholesterol metabolism, antioxidant activities, and serum and hepatic lipids in rats fed a high-fat diet through gavage. Methodology: We used 4-week-old male Wistar 20 rats in our animal experiment. Biochemical indicators of fecal, serum and liver were tested by kits or chemical methods. We also conducted the cholesterol micellar solubility experiment in vitro. Results: After 28 days of treatment, our results showed that WGP significantly reduced the serum levels of total cholesterol (p < 0.05) and nonhigh-density lipoprotein cholesterol (p < 0.05), improved the enzymatic activities of cholesterol 7-α hydroxylase (p < 0.01) and low-density lipoprotein receptor (p < 0.01) and increased bile acid excretion in feces (p < 0.05). Conclusion: WG did not significantly increase bile acid excretion in feces or decrease serum levels of total cholesterol. Moreover, WGP and WG both presented significant antioxidant activity in vivo (p < 0.05) and caused a significant reduction in cholesterol micellar solubility in vitro (p < 0.001). Therefore, WGP may effectively prevent hyperlipidemia and its complications as WGP treatment enhanced antioxidant activity, decreased the concentration of serum lipids and improved the activity of enzymes involved in cholesterol metabolism.

show abstract

Jaboticaba (Myrciaria cauliflora) Peel Supplementation Prevents Hepatic Steatosis Through Hypolipidemic Effects and Cholesterol Metabolism Modulation in Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model

Cited by 8 publications

References 47 publications

Wax apple (Syzygium samarangense) fruit extract ameliorates endothelial dysfunction and liver damage in high cholesterol diet-fed rats

Wax apple (Syzygium samarangense) fruit extract ameliorates endothelial dysfunction and liver damage in high cholesterol diet-fed rats

Effects of Banana (Musa spp.) Bract Flour on Rats Fed High-Calorie Diet

The Hypolipidemic and Antioxidant Activity of Wheat Germ and Wheat Germ Protein in High-Fat Diet-Induced Rats

Contact Info

Product

Resources

About