Jacques Forestier (1890–1978) and gold therapy

Healy, Maureen; Lim, Ken‐Hong; Travers, Richard

doi:10.1111/j.1756-185x.2009.01407.x

Cited by 9 publications

(3 citation statements)

References 12 publications

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“…Metal-based drugs have been used for the treatment of numerous diseases since the last centuryand represent important tools in contemporary medicine. [1] Gold salts were tested against tuberculosis andw ere employed as antirheumatics from the beginning of 20 th century, [2] but it is only with the discovery of cisplatin, [3] as one of the most powerful chemotherapeutic agents against ovarian and testicular cancer,t hat the interest for new metal-based therapeutic drugs starts. In particular,o ther platinum(II)-, ruthenium(II/III)-and gold(I/III)-based drugs, such as oxaliplatin,N AMI-A, KP1019, RAPTA-T or auranofin ( Figure 1), have been pioneer compounds for their use in cancer therapy.…”

Section: Metallic Drugsmentioning

confidence: 99%

Heterobimetallic Complexes for Theranostic Applications

Fernández‐Moreira

Gimeno

2018

Chemistry A European J

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The design of more efficient anticancer drugs requires a deeper understanding of their biodistribution and mechanism of action. Cell imaging agents could help to gain insight into biological processes and, consequently, the best strategy for attaining suitable scaffolds in which both biological and imaging properties are maximized. A new concept arises in this field that is the combination of two metal fragments as collaborative partners to provide the precise emissive properties to visualize the cell as well as the optimum cytotoxic activity to build more potent and selective chemotherapeutic agents.

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Section: Metallic Drugsmentioning

confidence: 99%

Heterobimetallic Complexes for Theranostic Applications

Fernández‐Moreira

Gimeno

2018

Chemistry A European J

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“…The documented history of noble metal-based drugs started with the chance discovery of cisplatin (cis-diamminedichloroplatinum(II)) [1][2] as one of the most powerful chemotherapeutic agents against ovarian and testicular cancer, although gold salts had been tested against tuberculosis and were employed as antirheumatics in 1929 [3]. Since then, a vast library of metal complexes has been synthesized and applied in the pharmacological field, mostly as anticancer agents, but also as anti-inflammatory, antibacterial, antirheumatic, and antimalarial drugs.…”

Section: Introductionmentioning

confidence: 99%

Noble metals in medicine: Latest advances

Medici

Peana

Nurchi

et al. 2015

Coordination Chemistry Reviews

654

345

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“…The interest in using gold and its complexes dates back to ancient times and was also an important aspect of alchemy in medievalE urope and in the Renaissance period, when gold was an essentiali ngredient of so-called aurumv itae medicines. [1] Early scientific reports by Robert Koch demonstrated antibacterial activities of gold cyanide salts, [2] and with the contributionso fF orestier, [3] goldc omplexes found their way into modernd rug therapy.C urrently,g old-based drugs such as Auranofin are still in use for the treatment of symptoms of rheu-matoid arthritis. More recently,t he possible therapeutici mpact of gold complexes has caught the attention of inorganic medicinal chemists due to their strong effects against the growth of cancercells and pathogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram‐Positive Directed Antibacterial Effects

Schmidt

Karge

Misgeld

et al. 2017

Chemistry A European J

158

139

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Gold complexes with N-heterocyclic carbene (NHC) ligands represent a promising class of metallodrugs for the treatment of cancer or infectious diseases. In this report, the synthesis and the biological evaluation of halogen-containing NHC-Au -Cl complexes are described. The complexes 1 and 5 a-5 f displayed good cytotoxic activity against tumor cells, and cellular uptake studies suggested that an intact Au-NHC fragment is essential for the accumulation of high amounts of both the metal and the NHC ligand. However, the bioavailability was negatively affected by serum components of the cell culture media and was influenced by likely transformations of the complex. One example (5 d) efficiently induced apoptosis in vincristine- and daunorubicin-resistant P-glycoprotein overexpressing Nalm-6 leukemia cells. Cellular uptake studies with this compound showed that both the wild-type and resistant Nalm-6 cells accumulated comparable amounts of gold, indicating that the gold drug was not excreted by P-glycoprotein or other efflux transporters. The effective inhibition of mammalian and bacterial thioredoxin reductases (TrxR) was confirmed for all of the gold complexes. Antibacterial screening of the gold complexes showed a particularly high activity against Gram-positive strains, reflecting their high dependence on an intact Trx/TrxR system. This result is of particular interest as the inhibition of bacterial TrxR represents a relatively little explored mechanism of new anti-infectives.

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Jacques Forestier (1890–1978) and gold therapy

Cited by 9 publications

References 12 publications

Heterobimetallic Complexes for Theranostic Applications

Heterobimetallic Complexes for Theranostic Applications

Noble metals in medicine: Latest advances

Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram‐Positive Directed Antibacterial Effects

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