Work is a demand for an adult, because through working, person can actualize their skill and achieve their aspiration. Beside that through working, person can meets their basic needs of life. Yet, working also has a hidden threat that can be suddenly attack and eradicate the well being of person. Those hidden threat is called as a strain and stress.The present study purposes to examine relationship between job insecurity, and the role of religious coping as moderator variables with job stress among Javanese academic staff. Contextual factor should be considered to achieve more in depth comprehension about dynamic relationship of job stress, especially this study take Javanese culture account for understanding of contextualizing theory of job stress. Moderated multiple regression was conducted to examine this issue.The result of study confirmed that there is a significant relationship between job insecurity with job stress, and religious coping moderate the relationship between job insecurity with job stress. The mechanism of relationship among exogenous and endogenous variables was discussed in a paper below.