Kampo Medicines for Mite Antigen‐Induced Allergic Dermatitis in NC/Nga Mice

Gao, Xiu Kun; Fuseda, Kazutoshi; Shibata, Tomohiko; Tanaka, Hiroyuki; Inagaki, Nobuya; Nagai, Hiroichi

doi:10.1093/ecam/neh077

Cited by 70 publications

(66 citation statements)

References 35 publications

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“…The development of dermatitis was accompanied by an increase in serum IgE levels and by increased IL-4 and decreased IFN-levels in the splenocytes. According to a report by Gao et al, 22) it was confirmed that continuous application of mite antigens to the auricles of NC/Nga mice once a week for 4 weeks continuously resulted in increased serum IgE levels and in increased IL-4 and decreased IFN-mRNA expression levels in the auricular tissue. We believe that their report corresponds well to the results of the present study.…”

Section: Discussionmentioning

confidence: 87%

Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice

Hokazono

Omori²,

Ono

2010

Bioscience, Biotechnology, and Biochemistry

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We examined the effects single and combined administration of fermented barley extract P (FBEP), prepared from barley-shochu distillery by-products, and -aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Single administration of FBEP and GABA dose-dependently reduced the development of AD-like skin lesions in mice. GABA reduced the development of AD-like skin lesions by suppressing serum immunoglobulin E (IgE) and splenocyte interleukin (IL)-4 production, while FBEP reduced skin lesions without affecting the IgE or cytokine production. However, in mice with induced AD-like skin lesions, combined administration of FBEP and GABA decreased serum IgE levels and splenic cell IL-4 production, and increased splenic cell interferonproduction. These results suggest that combined administration of FBEP and GABA alleviated AD-like skin lesions in the NC/Nga mice by adjusting the Th1/Th2 balance to a Th1-predominant immune response.

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Section: Discussionmentioning

confidence: 87%

Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice

Hokazono

Omori²,

Ono

2010

Bioscience, Biotechnology, and Biochemistry

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“…22) All herbal formulas effectively suppressed dermatitis, and prevented increase of IL-4 mRNA expression and decrease of IFN-g levels. Juzentaihoto and hochuekkito also inhibited IgE hyperproduction.…”

Section: Discussionmentioning

confidence: 96%

Effect of Bakumijiogan, an Herbal Formula in Traditional Chinese Medicine, on Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Jic Mice

Makino

Hamanaka

Yamashita

et al. 2008

Biological & Pharmaceutical Bulletin

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Atopic dermatitis (AD) is a common skin disease characterized by pruritus, eczematous skin lesions, and a chronically relapsing course.2) The pathogenesis of AD is multifactorial, and genetically determined immunologic aberrations are thought to play an important role in it. The mechanisms involved in disease development are incompletely understood, but mite antigen is thought to be one of the pathogens because patients have elevated serum levels of immunoglobulin-E (IgE) against the allergen.3) There is some evidence that T-cell responses to the allergen are crucial for AD aggravation. 4) It has been accepted that topical steroid therapy is crucial for AD management, but they cannot be used for long periods because of frequent side effects. Steroid therapy can improve topical cutaneous symptoms, but cannot completely cure the disease. Many patients therefore choose to explore complementary/alternative medicines including herbal medicine.5) Traditional Chinese medicine (TCM) and traditional Japanese medicine (Kampo) have been receiving increasing attention as alternative sources of treatment for chronic diseases, including AD. TCM is believed to have the potential to treat patients holistically by supporting the patient's selfhealing power.6,7) However, the dearth of scientific evidence of TCM has restricted its polular use.A murine strain, NC, is a well-known animal model for AD and has been extensively used to elucidate AD pathogenesis and development. NC mice spontaneously develop ADlike eczematous skin lesions with IgE hyperproduction when raised under conventional conditions, but not under specific pathogen-free conditions.8) It was revealed that environmental antigens such as Dermatophagoides farinae (Df) were involved in the pathogenesis of AD-like symptoms in NC mice. Repeated extraneous injections of the antigen to NC mice caused severe and settled dermatitis, which could then be used as a model to evaluate new pharmaceutics for AD treatment. 9-11)We evaluated the effect of bakumijiogan (BJG) on the AD model induced by repeated Df-antigen injections in NC/Jic mice. BJG is a modified herbal formula of rokumigan. Rokumigan consists of six crude drugs (Table 1) and is a basic formula used to treat kidney-yin deficiency, which according to the TCM theory is a condition characterized by tidal fever, spontaneous sweating, dizziness, tinnitus, spermatorrhea (in males), and sexual intercourse in dream (in famales). Six crude drugs contained in rokumigan and two additional crude drugs, ophiopogon tuber (bakumondo in Japanese, B) and schisandra fruit (gomishi in Japanese, G), constitute BJG (Table 1). In the TCM theory, the targeted conditions for BLG use include deficiency of lung-kidney-yin, reversed flow of qi, tidal fever, and night sweats. BJG has therefore been given to patients with asthma, AD, or systemic lupus erythematosus. 12) MATERIALS AND METHODS Preparation of Herbal FormulasAll crude drugs in the Japanese Pharmacopoeia XV 13) were purchased from Tsumura Co. Ltd. (Tokyo). The composition of BJG and ...

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“…. 그러나 각종 부작용으로 인해 효과적이 고 안전한 천연물 치료제에 대한 요구가 증가하고 있 으며 24,25) , 이에 따라 치료효과가 높고 부작용이 적은 치료제를 천연물이나 한약에서 찾고자 하는 시도가 끊 임없이 이루어지고 있다 26,27) .…”

Section: Tnf-α 생성 조절에 Nj의 효과를 측정하기 위하여unclassified

Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions

Min

Park²

2012

The Journal of Korean Oriental Pediatrics

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ObjectivesNJ is being used to treat inflammatory diseases in Korea. In this study, we attempted to evaluate the effects of NJ on atopic dermatitis (AD)-like lesions and mast cell-mediated allergy inflammation in vivo and in vitro. Methods and ResultsWe investigated to ascertain the pharmacological effects of NJ on 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find possible explanations for the anti-inflammatory mechanisms of NJ, we evaluated the regulatory effects of NJ on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). ConclusionsNJ inhibited the production of the inflammatory cytokines (IgE, IL-6, IL-8 and TNF-α) significantly in vivo and in vitro.

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Kampo Medicines for Mite Antigen‐Induced Allergic Dermatitis in NC/Nga Mice

Cited by 70 publications

References 35 publications

Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice

Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice

Effect of Bakumijiogan, an Herbal Formula in Traditional Chinese Medicine, on Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Jic Mice

Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions

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