Kaposi's Sarcoma In Cyclosporine-Induced Gingival Hyperplasia

Qunibi, Wajeh Y.; Akhtar, Mohammed; Ginn, Earl; Smith, Philip H.

doi:10.1016/s0272-6386(88)80142-2

Cited by 31 publications

(10 citation statements)

References 3 publications

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“…Oral KS has been described in organ transplant patients in two case reports (63,64). In one case, KS developed in a cyclosporin-induced gingival overgrowth (64), whilst the other developed in the gingival tissues of a renal transplant patient shortly after an acute infection with cytomegalovirus (63). Apart from these two reports, there is no information on the prevalence of ora!…”

Section: Oral Malignancymentioning

confidence: 99%

“…Drug-induced gingival overgrowth is a common problem in organ transplant patients that often requires surgical excision (see later). It has been reported that Kaposi's sarcoma and squamous cell carcinoma can arise in gingival overgrowths in organ transplant pa-tients (64,76). in both cases there were significant clinical changes in the gingival tissues to justify biopsy.…”

Section: Oral Malignancymentioning

confidence: 99%

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Oral lesions in organ transplant patients

Seymour

Thomason

Nolan

1997

J Oral Pathology Medicine

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Patients who have undergone organ transplantation can present with a variety of oral lesions that appear to be related either directly to their medication or arise as a consequence of drug-induced immunosuppression. Such lesions include hairy leukoplakia, an increased propensity to both fungal and viral infections and a high incidence of malignant change, especially lip cancer. Cyclosporin remains the immunosuppressant of choice in most transplant patients. Gingival overgrowth is the main unwanted oral effect associated with cyclosporin. Some 30% of dentate transplant experience this problem, which is further compounded by concomitant medication with a calcium channel blocker. This review appraises the various oral problems that can arise in this group of patients and emphasises the importance of regular oral screening and the establishment of links with the various transplant teams.

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Section: Oral Malignancymentioning

confidence: 99%

Section: Oral Malignancymentioning

confidence: 99%

Oral lesions in organ transplant patients

Seymour

Thomason

Nolan

1997

J Oral Pathology Medicine

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“…Early experience of cyciosporin usage in patients indicated a possible link between the drug and the development of lymphoproliferative disorders, possibly as a result of an association with the Epstein-Barr virus (Nagington & Gray 1980), A 10% incidence of lymphoma was reported in the first series of renal transplant patients receiving cyciosporin (Caine et al, 1978), Later studies have failed to confirm this high incidence with only 3 cases of lymphoma reported in a series of 58 renal transplant patients (Caine et al, 1981), Increased neoplasia is a common finding in transplant recipients (Penn 1969(Penn , 1983a, although the carcinogenic potential of cyciosporin A when used as the sole immunosuppressant agent has yet to be determined (Penn 1987), The incidence of Kaposi's sarcoma is also increased in immunosuppressed patients (Penn 1983b) and gingival Kaposi's sarcoma has occurred in two patients. This suggests the need for biopsy in cases of severe gingival overgrowth (Qunibi et al, 1988),…”

Section: Other Unwanted Effectsmentioning

confidence: 99%

Cyclosporin and the gingival tissues

Seymour

Jacobs

1992

J Clinic Periodontology

168

115

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Cyclosporin is a selective immunosuppressant that has a variety of applications in medical practice. Like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. This review considers the pharmacokinetics, pharmacodynamics, uses and unwanted effects of cyclosporin, in particular the action of the drug on the gingival tissues. Clinical and cell culture studies suggest that the mechanism of gingival overgrowth is a result of an interaction between the drug and its metabolites with susceptible gingival fibroblasts. Plaque-induced gingival inflammation appears to enhance this interaction.

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“…Le SK peut aussi simuler une hyperplasie gingivale, notamment dans un contexte de prise de ciclosporine. Qunibi et al [22] ont rapporté 2 cas où le SKPT était « intégré » dans une hyperplasie gingivale due à la ciclosporine. Toutefois, cette dernière donne souvent une hyperplasie fibreuse, étendue, associée à un érythème généralisé tandis que le SKPT se traduit par des lésions localisées et rouge violacé [4,22,23].…”

Section: Diagnostic Différentielunclassified

Sarcome de Kaposi buccal post-transplantation rénale : présentation d’un cas et revue de la littérature

Hasna

Slama

Sahtout

et al. 2013

Med Buccale Chir Buccale

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Résumé -Abstract -Oral Kaposi sarcoma after renal transplantation: a case report and review of literature. The immunosuppressive therapies are associated with an increase in the risk of Kaposi sarcoma among transplant patients. The management of these tumours is challenging as the immunosuppression must be monitored to prevent a potential transplant rejection. In 2009, a 48-year-old patient was referred to us by the nephrology department for a suspicious palatal lesion. The patient having had a renal transplantation in 2008 was under immunosuppressants. The intra-oral examination revealed a right red-purple palatal swelling, of 2.5 cm in long axis, painless, with firm consistency on palpation. The buccal vestibule was clear. No satellite adenopathy was observed. A biopsy revealed Kaposi sarcoma. An assessment of the local and general extension concluded an absence of an underlying osseous involvement as well as other remote locations. The treatment consisted of a modification of immunosuppressants associated with tumor resection surgery. The loss of mucous substance was repaired by an advanced vestibular flap and rotational palatal flap. The histology confirmed the diagnosis of Kaposi sarcoma and the limits of curative surgery. A 14-month follow-up showed a favorable evolution. Local and regional monitoring did not reveal any recurrence signs; this was confirmed by CTscan follow-up examination. Subsequently, the patient underwent a prosthetic restoration by means of a removable partial denture.

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Kaposi's Sarcoma In Cyclosporine-Induced Gingival Hyperplasia

Cited by 31 publications

References 3 publications

Oral lesions in organ transplant patients

Oral lesions in organ transplant patients

Cyclosporin and the gingival tissues

Sarcome de Kaposi buccal post-transplantation rénale : présentation d’un cas et revue de la littérature

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