Karakteristik Klinis Pasien Epilepsi Di Poliklinik Saraf Rsup Sanglah Periode Januari  – Desember 2016

Maryam, Izzati Shoba; Wijayanti, Ida Ayu Sri; Tini, Kumara

doi:10.29342/cnj.v1i3.29

Cited by 12 publications

(15 citation statements)

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“…Almost all studies examine epilepsy, which based on gender, focused on the characteristics of epileptic seizures rather than patients characteristics [9,10]. Related to age, older ages also have a higher risk of being exposed to epileptic risk factors such as; head trauma, central nervous system infection, space-occuping lesions, blood circulation disorders, toxin (alcohol and drugs), metabolic disoders and neurodegenerative disorders [8].…”

Section: Resultsmentioning

confidence: 99%

“…Study conducted in Harapan Kita Jakarta Hospital showed that 53.1% out of 141 patients were idiopathic [26] In previous study, it also found that idiopathic etiology dominated with a total of 74 patients (71.2%) [27]. Study in Sanglah Hospital had the most idiopathic patients with a total of 205 patients (74.4%) [8].…”

Section: Epilepsy Patients Characteristics Based On Etiologymentioning

confidence: 88%

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The Characteristics of Epilepsy in Healthcare Facilities in Medan Period of 2015–2020

Wiguna¹,

Fitri²,

Batubara³

2023

Advances in Health Sciences Research

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Background: Epilepsy is brain disorder marked by the tendency to continuously causing epileptic raise with neurobiological, cognitive, psychological, and social consequences. About 50 million people worldwide have epilepsy, making epilepsy the most common neurological disease globally. There are minimal data on the prevalence of epilepsy patients in Medan.Objective: To determine the characteristics of epilepsy in health facilities in Medan from 2015 to 2020.Method: This was a descriptive observational study with a cross-sectional design, using secondary data obtained from medical record of 4 hospitals and 10 health centers in Medan from the period 2015-2020, collected using the total sampling method.Results: The population of epilepsy patients in Medan City is in the amount of 847 people. The median value of age 32 (18-89) years with the most age range is 18-28 years old in the amount of 362 subjects (42.7%) and onset age is dominated by age range 11-21 years old in the amount of 230 subjects (27.2%). The most sex is male with 441 subjects (52.1%). The most educational background is senior high school graduates with 483 subjects (57.0%). The most work status is employed with 435 subjects (51.4%). The most health facility is at Hospital Type A with 278 subjects (32.8%). The most illness duration is ≤ 5 years with 617 subjects (72.9%). The most dominated by generalized seizure patient with 495 subjects (58.4%). OAB type is valproate acid in the amount of 222 subjects (26.2%) and polytherapy with total subjects 474 (56.0%). The most ethiology is idopatic with 671 subjcets (79.2%). The most EEG description is abnormal with total subjects 663 (78.3%), 508 subjects (59.9%) did not conduct imaging examination.Conclusion: The prevalence of epilepsy patients in Medan from 2015 -2020 period was 847 and dominated by the young adult group and men. Mostly were high school graduates and working. Most patients were found in type A hospital, were idiopathic, suffered a generalized seizures, were treated with polytherapy, and mostly consumed valproic acid. Most patients had abnormal EEG images and didn't do any imaging.

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Section: Resultsmentioning

confidence: 99%

Section: Epilepsy Patients Characteristics Based On Etiologymentioning

confidence: 88%

The Characteristics of Epilepsy in Healthcare Facilities in Medan Period of 2015–2020

Wiguna¹,

Fitri²,

Batubara³

2023

Advances in Health Sciences Research

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“…Fenitoin banyak digunakan di negara-negara berpenghasilan rendah-menengah seperti Asia, Afrika, dan Amerika Selatan karena biaya obat yang murah (Nevitt et al, 2019). Beberapa penelitian di Indonesia menyebutkan bahwa fenitoin merupakan OAE yang paling sering digunakan sebagai monoterapi (Maryam et al, 2018;Nahdhiyah et al, 2021;Tedyanto et al, 2020). Jumlah dosis per hari yang minimal, yakni sekali hingga dua kali sehari, dinilai cukup praktis dalam penggunaannya.…”

Section: Pendahuluanunclassified

Effectivity of Pyridoxine as Adjuvant Therapy of Phenytoin in Patients with Epilepsy at Soebandi Regional Hospital Jember

Putri

Abrori²,

Putri³

2022

JMJ

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Phenytoin is an antiepileptic drug used as monotherapy for partial and generalized tonic-clonic seizures for more than 50 years. Pyridoxine is a water-soluble vitamin widely used for seizure patients unresponsive to standard treatment regimens. This study was conducted to determine the effect of pyridoxine as adjuvant therapy in epilepsy patients receiving phenytoin and to determine the relationship between age, gender, type of epilepsy, and duration of therapy on the incidence of seizures in epilepsy patients at Soebandi Regional Hospital Jember. This research is an observational analytic study with a cross sectional design. The data was taken from the patient's medical record at Soebandi Hospital Jember. The number of samples in each treatment group was 18 samples so the total number of samples in this study was 36 samples. Samples were taken using total sampling technique. Data analysis was performed using Chi-Square test on bivariate analysis and The Logistic test on multivariate analysis. The sample in this study was dominated by male patients (52.8%), aged 19-59 years (52.8%), had epilepsy with generalized seizure type (86.1%), and received therapy for < 3 years (77.8%). The results of bivariate and multivariate analysis showed correlation between the administration of pyridoxine and the incidence of seizures, indicating that phenytoin therapy with pyridoxine adjuvants was more effective than monotherapy phenytoin. Other factors such as gender, age, type of epilepsy, and duration of therapy were not proven to have a correlation with the incidence of seizures in epilepsy patients at Soebandi Hospital Jember.

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“…38 Namun hal ini tidak sesuai dengan penelitian Maryam et al (2018) bahwa mayoritas pengobatan pasien dengan epilepsi menggunakan fenitoin (44,8%), yang diikuti dengan karbamazepin (32,2%) baik secara monoterapi ataupun kombinasi. 42 Pada penelitian lain, disebutkan bahwa obat antiepilepsi terbanyak yang digunakan pada pasien pediatrik adalah asam valproat (89,3%) secara monoterapi yang merupakan pilihan pertama karena tingkat keberhasilannya lebih tinggi yaitu 64,7%. 17 Fenobarbital monoterapi lebih sedikit digunakan karena fenobarbital bukan merupakan firstline terapi untuk epilepsi pada anak.…”

Section: Pembahasanunclassified

Effects of Antiepileptic Drug Levels on Clinical Outcomes in Pediatric Patients Using Pharmacokinetics Approach

Suryoputri

Endriastuti

Ilma

2021

Indones J Clin Pharm

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The high prevalence of antiepileptic drug use in pediatrics increases the risk of side and toxic effects; therefore, it is necessary to monitor drug levels. Therapeutic drug monitoring is conducted through pharmacokinetics by calculating blood drug levels based on respondents' dose and frequency of therapy. This study aimed to determine the pharmacokinetics of antiepileptic drug levels and the correlation with clinical outcomes using descriptive observational design. Furthermore, the Indonesian Epilepsy Community collected respondents' data from June to July 2020 through online and telephone interviews. Out of the 11 respondents that recieved phenytoin, only 1 (9.09%) was in the therapeutic range (10–20 mg/L), while 10 (90.91%) were outside the therapeutic range (<10mg/L). From the 14 respondents that received phenobarbital, 8 (57.14%) were in the therapeutic range (15–40 mg/L), and 6 (42.86%) were outside the therapeutic range (<15 mg/L and >40 mg/L). From the 47 respondents that received valproic acid, 23 were administered through monotherapy, 7 (30.44%) were in the therapeutic range (50–100 mg/L), and 16 (69.56%) were outside the therapeutic range (<50 mg/L and >100mg/L). Out of the 24 respondents that received valproic acid as monotherapy, 18 (75%) were in the therapeutic range (50–100 mg/L), and 6 (25%) were outside the therapeutic range (<50 mg/L and >100mg/L). The results showed that there was no significant relationship (p>0.05) between drug levels and clinical outcome in respondents treated with either monotherapy or polytherapy of valproic acid. In conclusion, a total of 38 respondents (52.05%) had drugs levels outside the therapeutic range, while 35 (47.95%) had drug levels in the therapeutic range. Furthermore, respondents with drug levels outside the therapeutic range require direct monitoring of antiepileptic drug levels to avoid toxic effects and improve clinical outcomes.

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Karakteristik Klinis Pasien Epilepsi Di Poliklinik Saraf Rsup Sanglah Periode Januari – Desember 2016

Cited by 12 publications

References 0 publications

The Characteristics of Epilepsy in Healthcare Facilities in Medan Period of 2015–2020

The Characteristics of Epilepsy in Healthcare Facilities in Medan Period of 2015–2020

Effectivity of Pyridoxine as Adjuvant Therapy of Phenytoin in Patients with Epilepsy at Soebandi Regional Hospital Jember

Effects of Antiepileptic Drug Levels on Clinical Outcomes in Pediatric Patients Using Pharmacokinetics Approach

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