Keratosis of the Larynx

Glottic Keratosis: Significance and Identification of Laryngoscopic Findings

“… 3 , 17 Erythroplakia and specifically erythrokeratosis, which is the presence of both keratosis and erythroplakia, have been recognized as lesions concerning for malignancy at least as early as 1946. 1 , 3 Clerf 1 described glottic keratoses with inflammatory changes on mirror laryngoscopy that on histopathology were suggestive of early carcinoma. Some of these lesions progressed, and subsequent biopsy specimens showed definite infiltration of the basement membrane.…”

“…Glottic keratosis is used to describe both the clinical appearance of white glottic lesions as well as a histological term to indicate squamous epithelial thickening with keratinization. 1 , 2 The clinical appearance of keratosis could be flat or raised, smooth or nodular, localized or diffuse, and surrounded by either normal or inflamed tissue. 3 Keratosis is often used interchangeably with leukoplakia , even though the latter means “white patch.” Keratosis may be associated with phonotraumatic lesions, and these generally have low malignant potential.…”

Evolution of precancerous laryngeal lesions: A clinicopathologic study with long-term follow-up on 259 patients

“…Subsequently, several Authors (Clerf, 2 Gordon, 3 Ellis 4 ) used such a definition as a model to indicate similar lesions in different laryngeal sites considering mainly the macroscopic (clinical) appearance of the pathology independently from the actual histologic diagnosis. However, from a therapeutic and prognostic point of view such a terminology could not be considered precise because it did not take into consideration eventual microscopic alterations such as the presence or the absence of cellular atypia and the grading of subsequent dysplastic changes.…”

“…This terminology is introduced in the recent literature and widely accepted. [11][12][13][14][15] Our work has taken into consideration this new definition and has classified keratosis into four groups: (1) keratosis without dysplasia, (2) keratosis with mild dysplasia (LIN 1), (3) keratosis with moderate dysplasia (LIN 2), and (4) keratosis with severe dysplasia or carcinoma in situ (LIN 3).…”

XXXIV The Clinical Significance of Keratosis of the Larynx as a Premalignant Lesion

“…The cases forming the basis of this report were classified clinically into three groups: (1) those which were carcinoma when first seen (57 cases), (2) those which were first benign and later developed into carcinoma (27 cases), and (3) those which never showed evidence of malignant degeneration, some after years of observation (41 cases).…”