Ketorolac and pethidine in post-operative pain relief

Uddin, Md. Jashim; Hossain, Amir; Alam, Meer Mahbubul

doi:10.3329/bjp.v2i1.498

Cited by 3 publications

(6 citation statements)

References 20 publications

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“…However, at 18 and 48 hours, there was no significant difference in the mean VAS score (p>0.05). The incidence of sedation in patients using pethidine was significantly higher (p <0.05) than ketorolac during the entire period (6,12,18,24, 48 hours postoperatively).…”

Section: Resultsmentioning

confidence: 88%

“…This finding was 11 consistent with that of the study done by Burhan et al . The incidence of sedation in patients using pethidine was significantly higher (p <0.05) than ketorolac during the entire period (1,6,12,18,24, 48 hours postoperatively). This suggests that pethidine had pronounced sedative effect.…”

Section: Discussionmentioning

confidence: 88%

“…Ketorolac trometha mine is a NSAID with a potent analgesic and low incidence of side effects. Ketorolac does not depress ventilation and is not associated with nausea, vomiting, urinary retention, sedation 6 and itching and it reduces postoperative opiate requirements. Moreover, it has been successfully used to replace opioid in some situations involving mild to moderate postsurgical pain.…”

Section: Inclusion Criteriamentioning

confidence: 99%

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Comparative Study on Efficacy of Ketorolac and Pethidine for Postoperative Pain Management

Shrestha

Joshi

Palikhey

et al. 2019

J Univ Coll Med Sci

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INTRODUCTION: Postoperative pain management is essential for early mobilization and rehabilitation to enhance recovery and to reduce morbidity. Ketorolac and pethidine are two most common analgesics used in the postoperative setting for pain management. MATERIAL AND METHODS: Sixty patients (n=60) of age group 18-60 years who undergone various surgical procedures were divided randomly into two groups (T1 and T2). T1 group received inj. ketorolac 5 mg/kg IM and T2 group received pethidine 1.5 mg/kg IM body weight respectively on 6 hourly basis for 48 hours postoperatively. Patients were assessed in the recovery room for pain according to Visual Analogue Scale (VAS), Verbal Rating Scale (VRS) and Sedation Score after 1, 6, 12, 18, 24 and 48 hours of drug administration. Analgesic efficacy was measured using VAS and VRS. Safety of the drugs was assessed by using Sedation Score. RESULTS: Ketorolac showed equianalgesic effect as pethidine estimated by VAS score at 18th and 48th hour. In other periods of observation, pethidine exhibited better analgesic effects than ketorolac. However, ketorolac shows less incidence of sedation compared to pethidine. CONCLUSION: This study showed that postoperative pain during the first 48 hours can be relieved by either ketorolac or pethidine. Ketorolac appeared safer than pethidine while pethidine appeared more effective analgesic than ketorolac in the management of postoperative pain.

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Section: Resultsmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 88%

Section: Inclusion Criteriamentioning

confidence: 99%

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Comparative Study on Efficacy of Ketorolac and Pethidine for Postoperative Pain Management

Shrestha

Joshi

Palikhey

et al. 2019

J Univ Coll Med Sci

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“…Efek samping yang umum ditimbulkan antara lain adalah nyeri gastrointestinal, mual, dispepsia, dan pusing. 7,8 Penelitian ini mempergunakan kombinasi fentanyl patch 12,5 µg/jam dan 25 µg/jam dengan ketorolak 30 mg/i.v. yang merupakan analgesia preventif dan menghasilkan efek analgetik yang lebih baik.…”

Section: Pembahasanunclassified

“…Ketorolak merupakan struktur alfa pengganti asam arilasetik yang secara struktural kimia berhubungan dengan indometasin. 7,8 Penelitian ini bertujuan untuk mengetahui perbedaan efektivitas kombinasi fentanyl transdermal patch 12,5 µg/jam dan 25 µg/jam dengan ketorolak 30 mg/IV pada pascabedah ortopedi ekstremitas bawah memakai anestesi regional blokade subaraknoid.…”

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Perbandingan Efektivitas Kombinasi Fentanyl Patch 12,5 µg/jam dan 25 µg/jam dengan Ketorolak 30 mg Intravena pada Pascabedah Ortopedi Ekstremitas Bawah

Rini¹,

Ihsan²,

Lubis³

2016

jap

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AbstrakFentanyl patch dapat digunakan untuk manajemen nyeri pascabedah. Tujuan penelitian ini membandingkan efektivitas kombinasi fentanyl patch 12,5 µg/jam dan 25 µg/jam dengan ketorolak 30 mg intravena pada pascabedah ortopedi ekstremitas bawah dengan anestesi spinal. Penelitian ini merupakan uji klinis acak tersamar ganda pada 24 pasien dengan status fisik American Society of Anesthesiologist (ASA) I dan II, usia 18-50 tahun yang menjalani operasi ortopedi ekstremitas bawah di kamar operasi bedah sentral Rumah Sakit H. Adam Malik dan rumah sakit jejaring pada bulan Oktober-November 2015. Pasien dibagi menjadi dua kelompok, yaitu 12 orang menerima fentanyl patch 12,5 µg/jam (A) dan 12 orang menerima fentanyl patch 25 µg/jam (B) ditempelkan ±2 jam sebelum pembedahan dan dikombinasi dengan ketorolak 30 mg intravena yang diberikan saat dimulainya insisi. Penilaian skala nyeri dilakukan menggunakan nilai visual analog scale (VAS). Data hasil penelitian diuji dengan uji chi-square. Hasil perhitungan statistika didapatkan kombinasi kelompok fentanyl patch 25 µg/jam bermakna lebih efektif dibanding dengan kelompok fentanyl patch 12,5 µg/jam (p<0,05). Simpulan penelitian ini adalah secara klinis perbedaan nilai VAS kedua kelompok tidak berbeda. Kata Kunci:Efek samping, fentanyl patch, ketorolak, visual analog score (VAS) AbstractFentanyl patch is the first injection-free system for post surgery pain management that is a safe, easy to use, and comfortable modality for patient. The aim of this study was to differentiate the effectiveness and side effect of 12.5 µg/hour and 25 µg/hour fentanyl patch combinations with 30 mg intravenous ketorolac after orthopedic surgery of lower extremity under spinal anesthetic. This was a double random clinical trial for 24 patients with physical status American Society of Anesthesiologist (ASA) I and II, 18-50 years old of age, who underwent orthopedic extremity surgery in the operating theaters of H. Adam Malik Hospital and other hospitals in October-November 2015. Patients were divided into two groups, i.e. 12 patients received 12.5 µg/hour fentanyl patch (A) and 12 patients received 25 µg/hour fentanyl patch (B) for ±2 hours before surgery, combined with 30 mg intravenous ketorolac given at the start of incision. The pain was scored using a visual analog scale. Data were then statistically analyzed using chi-square test. The result of the study showed that the use of 25 µg/hour fentanyl patch was significantly more effective than the 12.5 µg/ hour fentanyl patch (p<0.05). It is concluded that the clinical VAS scores for the two groups after orthopedic surgery of lower extremity are different.

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A comparative clinical evaluation of analgesic efficacy of Tapentadol and ketorolac in mandibular third molar surgery

Shah¹,

Shah²,

Mahajan³

et al. 2017

Natl J Maxillofac Surg

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Introduction:The surgical removal of impacted mandibular third molars is one of the most commonly performed dentoalveolar procedures in oral and maxillofacial surgery and is associated with varying degrees of postoperative discomfort. Pain, trismus, and swelling are the most common postoperative complaints, and these influence a patient's quality of life in the days after surgery.Materials and Methods:A comparative study of the 32 patients, 16 were allocated to receive ketorolac and 16 patients were allocated to receive tapentadol. As the data for this study were collected at different time points, analysis for the longitudinal study was done. The main outcome variable, pain level was measured in five-ordered categories. As we had ordinal data in our study, we first checked for marginal homogeneity through Cochran–Mantel–Haenszel test.Results:In the present study, the results show that there is no statistically significant difference between the two treatment groups (P = 0.1184). According to results, there is no significant group by time interaction, which means both drugs have shown almost equal efficacy at different time points. Similarly, there is no difference in efficacy of the two drugs across gender level.Conclusion:The present findings showed that there is no statistically significant difference between the two treatment groups, although ketorolac is more effective for immediate pain reduction than tapentadol. However, the overall reduction of pain using both groups has no significant difference.

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Ketorolac and pethidine in post-operative pain relief

Cited by 3 publications

References 20 publications

Comparative Study on Efficacy of Ketorolac and Pethidine for Postoperative Pain Management

Comparative Study on Efficacy of Ketorolac and Pethidine for Postoperative Pain Management

Perbandingan Efektivitas Kombinasi Fentanyl Patch 12,5 µg/jam dan 25 µg/jam dengan Ketorolak 30 mg Intravena pada Pascabedah Ortopedi Ekstremitas Bawah

A comparative clinical evaluation of analgesic efficacy of Tapentadol and ketorolac in mandibular third molar surgery

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