Ketorolac vs. tramadol for pain management after abdominal surgery in children

Hendarman, Iman; Triratna, Silvia; Kamaludin, Muhammad T.; Theodorus, Theodorus

doi:10.14238/pi54.2.2014.10

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 Other studies that concluded ketorolac to be as effective as tramadol were regarding maxillofacial surgery, 19 abdominal surgery. 20 Although we observed both the drugs were having a similar duration of the pain-free interval which proves their effectiveness in pain management, our next concern was safety. Studies have shown that ketorolac to be comparatively safer than tramadol.…”

Section: Discussionmentioning

confidence: 74%

A Comparative Study of Tramadol and Ketorolac for Pain Management in Post-Operative Patients with Appendectomy

2021

View full text Add to dashboard Cite

Appendectomy is one of the most common emergency surgical procedures performed in the world. The inflammation of the appendix triggers severe pain in the right lower quadrant of the abdomen. Additionally, the post-operative incision site pain may be distressing to the patients. Analgesic drugs like tramadol (opioid analgesics) and ketorolac (nonsteroidal anti-inflammatory drug - NSAID) are used to manage post-operative pain. The objective was to compare tramadol and ketorolac for pain management by observing the pain-free interval in post-operative patients with appendectomy. A descriptive cross-sectional study was conducted in the department of surgery from November 2019 to May 2020 to observe the duration of pain-free intervals between tramadol and ketorolac. The total number of appendectomy patients selected was 100. Fifty patients received tramadol and the next 50 patients received ketorolac. The data was entered in SPSS and an independent sample t-test was applied to determine the difference in duration of the pain-free interval between ketorolac and tramadol. The average duration of pain-free for the tramadol group was 4.95±1.19 hours (4 hours 57 minutes) while for the ketorolac group was 5.24±1.36 hours (5 hours 14 minutes). The difference was statistically insignificant. We also observed that the tramadol group (88%) received more anti-emetic drugs than the ketorolac group (24%). Therefore, post-operative pain management with ketorolac was found to be as effective as tramadol with comparable duration of the pain free interval.

show abstract

Section: Discussionmentioning

confidence: 74%

A Comparative Study of Tramadol and Ketorolac for Pain Management in Post-Operative Patients with Appendectomy

2021

View full text Add to dashboard Cite

show abstract

“…Ketorolac's action in the body are achieved by the reversible non-selective inhibition of the cyclooxygenase (COX) (COX1 and COX2 isoform) enzyme, thus interrupting arachidonic acid from converting to prostaglandins and relieving the pain, fever and inflammation produced (Botting 2006, Finkel et al 2009, Smyth and Fitz Gerald 2009, Hilal-Dandan and Brunton 2014. Ketorolac benefits as peripheral analgesics to manage moderate to severe pain and have few side effects only and considered a good approved, effective parenteral drug, cheaper and economic analgesics unlike other central opioids analgesic like tramadol and morphine which causes a serious side effects like respiratory depression and drug abuse (Jelinek 2000, Ollé et al 2000, Rainer et al 2000, Shankariah et al 2012, Hendarman et al 2014. The ketorolac's effect on non-opioid receptors lessens the risk of potentially additive side effects such as hemodynamic changes, central nervous system changes, or respiratory depression (Shankariah et al 2012, Rai andKiran 2013).…”

mentioning

confidence: 99%

Analgesic, antipyretic and anti-inflammatory efficacy of ketorolac in the chicks

Mousa

2019

Indian J of Anim Sci

View full text Add to dashboard Cite

Now-a-days, there is a need for newly, non-addicted and effective analgesics with less side effects. Therefore, the present study evaluated the analgesic, antipyretic and anti-inflammatory efficacy of ketorolac in 7â€“21 days old broiler chicks and its possible application in the related field. The analgesic median effective dose (ED50) of ketorolac that caused analgesia in 50% of the chicks was 9.1 mg/kg, intramuscular (IM). Ketorolac caused analgesic and antipyretic effects at multiple doses (5, 10 and 20 mg/kg, IM) in a dose dependent manner, whereas these percentages were significantly higher when ketorolac was injected @ 10 and 20 mg/kg, IM. All times recorded (15, 30, 60 and 120 min) for evaluating the analgesic effect of ketorolac produced analgesia while the higher and better analgesic efficacy was observed at 15 min after ketorolac injection. The injection of ketorolac @ 20 mg/kg, IM exerted anti-inflammatory activity by significantly reducing the right paw thickness of the chicks as a result of formaldehyde injection in comparison to control. There was no liver damage, impaired metabolism and function may be attributed to the ketorolac treatment in the chicks which was evaluated through estimation of serum AST and ALT concentrations. The study suggests the benefit of using ketorolac as an analgesic, antipyretic and antiinflammatory drug in the field of veterinary medicine due to its good, reliable and efficient efficacy.

show abstract

Ketorolac vs. tramadol for pain management after abdominal surgery in children

Cited by 2 publications

References 0 publications

A Comparative Study of Tramadol and Ketorolac for Pain Management in Post-Operative Patients with Appendectomy

A Comparative Study of Tramadol and Ketorolac for Pain Management in Post-Operative Patients with Appendectomy

Analgesic, antipyretic and anti-inflammatory efficacy of ketorolac in the chicks

Contact Info

Product

Resources

About