Key role of human leukocyte antigen in modulating human immunodeficiency virus progression: An overview of the possible applications

Grifoni, Alba; Montesano, Carla; Colizzi, Vittorio; Amicosante, Massimo

doi:10.5501/wjv.v4.i2.124

Cited by 5 publications

(3 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the HLA system plays an important role in the outcome and severity of many infectious diseases such as the human immunodeficiency virus [ 9 ] and the malaria parasite [ 10 ]. This role is pronounced in class I molecules that are expressed on all nucleated cells, and play a central role in immune regulation by presenting cytoplasmic peptides and in particular viral antigens.…”

Section: Discussionmentioning

confidence: 99%

Late antibody-mediated rejection in a kidney transplant recipient: COVID 19 induced?

et al. 2022

View full text Add to dashboard Cite

Background Antibody-mediated rejection (AMR) was described in kidney transplant patients after viral infections, such as the cytomegalovirus. Very few cases were recently reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, probably in the context of lowering of immunosuppressive therapy. To date, no direct immunological link was proved to explain a connection between the coronavirus disease 19 (COVID-19) infection and antibody-mediated rejection (AMR) if it exists. Case presentation Here we try to find this association by presenting the case of a low immunological risk patient who presented, six years post-transplant, with c4d negative antibody mediated rejection due to an anti-HLA-C17 de novo donor specific antibody (DSA) after contracting the coronavirus disease 19. The HLA-Cw17 activated the antibody-dependent cell-mediated cytotoxicity via the KIR2DS1 positive NK cells. Discussion and conclusions This case report may prove a direct role for COVID-19 infection in AMRs in the kidney transplant recipients, leading us to closely monitor kidney transplant recipients, especially if they have “at-risk” donor antigens.

show abstract

Section: Discussionmentioning

confidence: 99%

Late antibody-mediated rejection in a kidney transplant recipient: COVID 19 induced?

et al. 2022

View full text Add to dashboard Cite

show abstract

“…One key mechanism that viruses use to shape host immune recognition and attack is the alteration of HLA antigen expression on infected cells (54, 55). Fortunately, a large body of studies have revealed that particular KIR and HLA molecule interactions are significant in viral infection protection and control (56, 57).…”

Section: Function Of Human Leukocyte Antigen-f and Kir3ds1 Interactiomentioning

confidence: 99%

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

Lin

Yan

2019

Front. Immunol.

View full text Add to dashboard Cite

Human leukocyte antigens (HLAs) play various critical roles in both innate and adaptive immunity through processes such as presenting antigens to T cells and serving as ligands for receptors expressed on natural killer (NK) cells. Among the HLA class I family, the clinical significance and biological function of HLA-F have been the least investigated and have remained elusive for a long period of time. Previous studies have revealed that HLA-F expression might be involved in various physiological and pathological processes, such as pregnancy, viral infection, cancer, transplantation, and autoimmune diseases. However, recent data have shown that, akin to other HLA family members, HLA-F molecules can interact with both activating and inhibitory receptors on immune cells, such as NK cells, and can present a diverse panel of peptides. These important findings pave new avenues for investigations regarding the functions of HLA-F as an important immune regulatory molecule. In the present review, we summarize the studies on the role of HLA-F in immune modulation, with a special emphasis placed on the roles of HLA-F and KIR3DS1 interactions in viral infection.

show abstract

“…Human leukocyte antigen (HLA) plays an essential role in immune regulation. The polymorphisms of HLA are significantly related to the susceptibility and severity of many diseases, such as tumors (Sadagopan et al 2022 ), autoimmune diseases (Naito and Okada 2022 ), immunodeficiency diseases (Grifoni et al 2015 ), allergic diseases (Daya et al 2021 ), infectious diseases (Medhasi and Chantratita 2022 ), metabolic diseases (Tekola Ayele et al 2012 ), and so on. Each person has multiple alleles that make up the individual HLA type.…”

Section: Introductionmentioning

confidence: 99%

Targeted capture enrichment and sequencing identifies HLA variants associated with the severity of COVID-19

et al. 2022

View full text Add to dashboard Cite

Background Coronavirus disease 2019 (COVID-19) is currently a global pandemic. The pathogenesis of severe COVID-19 has been widely investigated, but it is still unclear. Human leukocyte antigen (HLA) plays a central role in immune response, and its variants might be related to COVID-19 progression and severity. Objective To investigate the hypothesis that individual HLA variations could alter the course of COVID-19 and might be associated with the severity of COVID-19. Methods In this study, we conducted an HLA targeted capture enrichment and sequencing of severe COVID-19 patients matched to mild cases. A total of 16 COVID-19 patients, confirmed by SARS-CoV-2 viral RNA polymerase-chain-reaction (PCR) test and chest computed tomography (CT) scan, were enrolled in this study. The HLA targeted capture enrichment and sequencing were conducted. HLA typing was performed by comparing contigs with IPD-IMGT/HLA Database. Results In this study, 139 four-digit resolution HLA alleles were acquired. The results showed that HLA-DRB3*01:01 allele was significantly associated with the severity of COVID-19 (odds ratio [OR] = 27.64, 95% confidence interval [CI] = 1.35–560.50, P = 0.0064). And HLA-K*01:01 might be a potential risk factor for COVID-19 severity (OR = 0.11, 95% CI = 0.017–0.66, P = 0.019), but HLA-K*01:02 might be a protective factor (OR = 7.50, 95% CI = 1.48–37.92, P = 0.019). Conclusion Three non-classical HLA alleles, including HLA-DRB3*01:01, HLA-K*01:01, HLA-K*01:02 were identified to be associated with the severity of COVID-19 by comparing mild and severe patients. The current findings would be helpful for exploring the influence of HLA gene polymorphisms on the development and severity of COVID-19. Supplementary Information The online version contains supplementary material available at 10.1007/s13258-022-01358-2.

show abstract

Key role of human leukocyte antigen in modulating human immunodeficiency virus progression: An overview of the possible applications

Cited by 5 publications

References 89 publications

Late antibody-mediated rejection in a kidney transplant recipient: COVID 19 induced?

Late antibody-mediated rejection in a kidney transplant recipient: COVID 19 induced?

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

Targeted capture enrichment and sequencing identifies HLA variants associated with the severity of COVID-19

Contact Info

Product

Resources

About