Kinematics and kinetics of people who are hypermobile. A systematic review

Bates, Alexander Vernon; Alexander, Caroline M.

doi:10.1016/j.gaitpost.2015.01.009

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…A customized quality checklist was developed in this review, applying an instrument proposed by Downs and Black 17 . Other authors have been using this checklist with adequate and customized questions [18][19][20] . It was originally designed to assess the methodological quality of randomized and non-randomized studies of interventions.…”

Section: Assessment Of Risk Of Bias (Methodological Quality)mentioning

confidence: 99%

Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis

Zanardi

Silva

Costa

et al. 2021

Sci Rep

126

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We systematically reviewed observational and clinical trials (baseline) studies examining differences in gait parameters between Parkinson’s disease (PD) in on-medication state and healthy control. Four electronic databases were searched (November-2018 and updated in October-2020). Independent researchers identified studies that evaluated gait parameters measured quantitatively during self-selected walking speed. Risk of bias was assessed using an instrument proposed by Downs and Black (1998). Pooled effects were reported as standardized mean differences and 95% confidence intervals using a random-effects model. A total of 72 studies involving 3027 participants (1510 with PD and 1517 health control) met the inclusion criteria. The self-selected walking speed, stride length, swing time and hip excursion were reduced in people with PD compared with healthy control. Additionally, PD subjects presented higher cadence and double support time. Although with a smaller difference for treadmill, walking speed is reduced both on treadmill (.13 m s−1) and on overground (.17 m s−1) in PD. The self-select walking speed, stride length, cadence, double support, swing time and sagittal hip angle were altered in people with PD compared with healthy control. The precise determination of these modifications will be beneficial in determining which intervention elements are most critical in bringing about positive, clinically meaningful changes in individuals with PD (PROSPERO protocol CRD42018113042).

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Section: Assessment Of Risk Of Bias (Methodological Quality)mentioning

confidence: 99%

Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis

Zanardi

Silva

Costa

et al. 2021

Sci Rep

126

View full text Add to dashboard Cite

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“…10,13 HSD patients tend to lack proprioceptive acuity, which may increase risk of injury. 14 In addition, patients tend to have decreased muscle mass and muscle strength, potentially due to increased laxity of tendons, which are unable to transmit power produced by muscles. 15,16 Altered biomechanics and posture can place overstress on muscles and fascia, causing additional pain.…”

Section: Joint Hypermobility and Hypermobility Spectrum Disorders-definitionsmentioning

confidence: 99%

Diagnosis and Management of Hypermobility Spectrum Disorders in Primary Care

et al. 2021

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Hypermobility spectrum disorders (HSDs) encompass an array of connective tissue disorders characterized by joint instability and chronic pain. Fatigue and other systemic symptoms that affect daily functioning may occur, as well. Accurate data on incidence and prevalence of HSDs is hampered by lack of awareness of these conditions and the wide heterogeneity of their clinical presentation. Identifying which type of HSD is present is important in guiding appropriate care. In particular, making the diagnosis of hypermobile Ehlers-Danlos syndrome (hEDS) is important, as individuals with hEDS may be at risk for more significant multisystem involvement. Diagnostic criteria for hEDS include measures of joint hypermobility, skin and other connective tissue findings, and lack of evidence of a different type of Ehlers-Danlos syndrome. Beyond accurate diagnosis, HSDs pose many challenges for primary care providers, as ongoing patient education, patient empowerment, and coordination of a multidisciplinary treatment team are integral to proper care. This article describes the incidence and prevalence, pathophysiology, diagnosis, and management of HSDs, including clinical cases exemplifying how joint hypermobility might present within a primary care setting.

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“…83 Early-onset osteoarthritis perception can also lead to increased risk of injury. 7,[84][85][86][87] Once injured, these patients also are also at increased risk of reinjury. 88 Chronic instability and altered joint biomechanics can lead to abnormal wear patterns and increased stress on articular cartilage, predisposing these patients to development of premature osteoarthritic changes in multiple joints.…”

Section: Elastic Fiber Genetic Disordersmentioning

confidence: 99%

“…Joint laxity can be a significant source of pain and disability in patients with hypermobility disorders, where blunted proprioceptive perception can also lead to increased risk of injury 7,84‐87 . Once injured, these patients also are also at increased risk of reinjury 88 .…”

Section: Implications For Musculoskeletal Function and Diseasementioning

confidence: 99%

Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions

Hill

Eekhoff

Brophy

et al. 2020

Journal Orthopaedic Research

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Elastic fibers are an essential component of the extracellular matrix of connective tissues. The focus of both clinical management and scientific investigation of elastic fiber disorders has centered on the cardiovascular manifestations due to their significant impact on morbidity and mortality. As such, the current understanding of the orthopedic conditions experienced by these patients is limited. The musculoskeletal implications of more subtle elastic fiber abnormalities, whether due to allelic variants or age-related tissue degeneration, are also not well understood. Recent advances have begun to uncover the effects of elastic fiber deficiency on tendon and ligament biomechanics; future research must further elucidate mechanisms governing the role of elastic fibers in these tissues. The identification of population-based genetic variations in elastic fibers will also be essential. Minoxidil administration, modulation of protein expression with micro-RNA molecules, and direct injection of recombinant elastic fiber precursors have demonstrated promise for therapeutic intervention, but further work is required prior to consideration for orthopedic clinical application. This review provides an overview of the role of elastic fibers in musculoskeletal tissue, summarizes current knowledge of the orthopedic manifestations of elastic fiber abnormalities, and identifies opportunities for future investigation and clinical application.

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Kinematics and kinetics of people who are hypermobile. A systematic review

Cited by 17 publications

References 26 publications

Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis

Gait parameters of Parkinson’s disease compared with healthy controls: a systematic review and meta-analysis

Diagnosis and Management of Hypermobility Spectrum Disorders in Primary Care

Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions

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