Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations

Hassan, Ekram M.; Belal, F.

doi:10.1016/s0731-7085(01)00473-3

Cited by 56 publications

(31 citation statements)

References 26 publications

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“…Redox reactions have been used as the basis for the development of simple and sensitive spectrophotometric methods for the determination of many compounds [33] [40]. Tartrazine reacts with KMnO 4 in strongly alkaline medium producing green manganate (λ max = 610 nm) (Figure 2(b)).…”

Section: Kmno 4 Oxidation Methodsmentioning

confidence: 99%

“…With addition of tartrazine solution, an absorption spectrum with two absorption bands at 390, 410 (double headed) and 610 nm was obtained. The latter band is attributed to the formation of manganate ion as a result of the oxidation of tartrazine with KMnO 4 in alkaline medium [33] [34] and the highly intense double headed band is related to Tz oxidized form.…”

Section: Absorption Spectra Of Tartrazine Reaction Productsmentioning

confidence: 99%

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Oxidation and Complexation-Based Spectrophotometric Methods for Sensitive Determination of Tartrazine E102 in Some Commercial Food Samples

Saleh¹,

Hashem²,

Salahi³

2016

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Section: Kmno 4 Oxidation Methodsmentioning

confidence: 99%

Section: Absorption Spectra Of Tartrazine Reaction Productsmentioning

confidence: 99%

Oxidation and Complexation-Based Spectrophotometric Methods for Sensitive Determination of Tartrazine E102 in Some Commercial Food Samples

Saleh¹,

Hashem²,

Salahi³

2016

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“…For these latter reasons, spectrophotometric methodologies, because of their inherent simplicity, low cost and wide availability were extensively proposed for R . HCl determination [19][20][21][22][23][24][25][26][27][28][29][30] . These methods are based on redox, coupling, charge-transfer complexation, and ion pair complexation reactions.…”

Section: Ranitidine N-(2-{[(5-dimethylamino)methyl]-2-furanyl}-methymentioning

confidence: 99%

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

Moldovan¹,

Aboul‐Enein²

2012

J. Chil. Chem. Soc.

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A new spectrophotometric method has been developed for the determination of ranitidine hydrochloride (R . HCl) in bulk drug and in tablet formulation. The proposed method involves the addition of a measured excess of bromate-bromide reagent in hydrochloric acid medium to R . HCl, followed by determination of residual bromine by reacting with a fixed amount of Rhodamine B (RB) and measuring the absorbance at λ max =557 nm. Beer's law was found in the range of 0.3-3.2 μg ml -1 of R . HCl, with a good correlation coefficient (r=0.9997). The limits of detection and quantification were calculated to be 0.08 μg ml -1 and 0.24mg ml -1 , respectively. The different experimental parameters affecting the development and stability of the proposed method were carefully studied and optimized. The validity of the proposed method tested by analyzing the pure and pharmaceutical formulations and compared well with those obtained by the official method, demonstrated good accuracy and precision.

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“…1 Several methods have been reported for the quantitative determination of RaCl. Among these are HPLC, 2-7 TLC, 8 capillary electrophoresis, 9,10 spectrophotometry, [11][12][13][14][15][16] NMR, 17,18 X-ray, 19 titrimetric methods, 20,21 and solid state ion-selective electrode. 22 Nevertheless, most of these methods involve several manipulation steps before the final result of the analysis.…”

Section: Introductionmentioning

confidence: 99%

Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques

2005

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New ranitidine hydrochloride (RaCl)-selective electrodes of the conventional polymer membrane type are described. They are based on incorporation of ranitidine-tetraphenylborate (Ra-TPB) ion-pair or ranitidine-phosphotungstate (Ra-PT) ion-associate in a poly(vinyl chloride) (PVC) membrane plasticized with dioctylphthalate (DOP) or dibutylphthalate (DBP). The electrodes are fully characterized in terms of the membrane composition, solution temperature, and pH. The sensors showed fast and stable responses. Nernstian response was found over the concentration range of 2.0 × 10 -5 M to 1.0 × 10 -2 M and 1.0 × 10 -5 M to 1.0 × 10 -2 M in the case of Ra-TPB electrode and over the range of 1.03 × 10 -5 M to 1.00 × 10 -2 M and 1.0 × 10 -5 M to 1.0 × 10 -2 M in the case of Ra-PT electrode for batch and FIA systems, respectively. The electrodes exhibit good selectivity for RaCl with respect to a large number of common ions, sugars, amino acids, and components other than ranitidine hydrochloride of the investigated mixed drugs. The electrodes have been applied to the potentiometric determination of RaCl in pure solutions and in pharmaceutical preparations under batch and flow injection conditions with a lower detection limit of 1.26 × 10 -5 M and 5.62 × 10 -6 M at 25 ± 1˚C. An average recovery of 100.91% and 100.42% with a relative standard deviation of 0.72% and 0.53% has been achieved.

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Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations

Cited by 56 publications

References 26 publications

Oxidation and Complexation-Based Spectrophotometric Methods for Sensitive Determination of Tartrazine E102 in Some Commercial Food Samples

Oxidation and Complexation-Based Spectrophotometric Methods for Sensitive Determination of Tartrazine E102 in Some Commercial Food Samples

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques

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