Kinetic studies on oxygen releasing of HBOC and red blood cells as fluids and factors affecting the process

Zhao, Baojuan; Zhang, Shengkang; Meng, Zhengyan; Wang, Dan; Li, Qian; Guo, Yan; Li, Fengjuan; Wang, Xiang; Yang, Chen

doi:10.1080/21691401.2018.1529677

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…HBOC may play important roles in transfusion medicine and are beneficial to anemia, trauma, and hypoxia-related diseases ( Jahr et al, 2021 ). YQ23 has a reduced affinity for oxygen (compared with free hemoglobin) and the p50 of hemoglobin in YQ23 is about 40 mmHg which is similar to RBC, and the oxygen releasing rate is faster than RBCs when oxygen partial pressure is low ( Zhao et al, 2018 ), which suggested fine oxygen carrying capacity and facilitated rapidly restoring the oxygen content in hypoxic tissues. YQ23 increased the oxygen supply and restored tissue hypoxia, and won opportunity for subsequent treatment ( Figure 4 ).…”

Section: Discussionmentioning

confidence: 99%

A Novel Cross-Linked Hemoglobin-Based Oxygen Carrier, YQ23, Extended the Golden Hour for Uncontrolled Hemorrhagic Shock in Rats and Miniature Pigs

Kuang

Zhu

et al. 2021

Front. Pharmacol.

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Background: Hypotensive resuscitation is widely applied for trauma and war injury to reduce bleeding during damage-control resuscitation, but the treatment time window is limited in order to avoid hypoxia-associated organ injury. Whether a novel hemoglobin-based oxygen carrier (HBOC), YQ23 in this study, could protect organ function, and extend the Golden Hour for treatment is unclear.Method: Uncontrolled hemorrhagic shock rats and miniature pigs were infused with 0.5, 2, and 5% YQ23 before bleeding was controlled, while Lactate Ringer’s solution (LR) and fresh whole blood plus LR (WB + LR) were set as controls. During hypotensive resuscitation the mean blood pressure was maintained at 50–60 mmHg for 60 min. Hemodynamics, oxygen delivery and utilization, blood loss, fluid demand, organ function, animal survival as well as side effects were observed. Besides, in order to observe whether YQ23 could extend the Golden Hour, the hypotensive resuscitation duration was extended to 180 min and animal survival was observed.Results: Compared with LR, infusion of YQ23 in the 60 min pre-hospital hypotensive resuscitation significantly reduced blood loss and the fluid demand in both rats and pigs. Besides, YQ23 could effectively stabilize hemodynamics, and increase tissue oxygen consumption, increase the cardiac output, reduce liver and kidney injury, which helped to reduce the early death and improve animal survival. In addition, the hypotensive resuscitation duration could be extended to 180 min using YQ23. Side effects such as vasoconstriction and renal injury were not observed. The beneficial effects of 5% YQ23 are equivalent to similar volume of WB + LR.Conclusion: HBOC, such as YQ23, played vital roles in damage-control resuscitation for emergency care and benefited the uncontrolled hemorrhagic shock in the pre-hospital treatment by increasing oxygen delivery, reducing organ injury. Besides, HBOC could benefit the injured and trauma patients by extending the Golden Hour.

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Section: Discussionmentioning

confidence: 99%

A Novel Cross-Linked Hemoglobin-Based Oxygen Carrier, YQ23, Extended the Golden Hour for Uncontrolled Hemorrhagic Shock in Rats and Miniature Pigs

Kuang

Zhu

et al. 2021

Front. Pharmacol.

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“…Different levels of hemoglobin concentrations in sepsis patients may be due to presenting conditions [4], nutritional deficiencies, inflammatory anemia [5][6][7], hemolysis [8,9], loss of bloodletting, loss of gastrointestinal tract, transfusion expansion, fluid load resulting in hemodilution [10], decreased bone marrow response to erythropoietin [11], inhibition of erythropoietin production by pro-inflammatory cytokines [7,12], response to drugs [13], inappropriate blood transfusion [14] and so on.…”

Section: Introductionmentioning

confidence: 99%

The correlation of hemoglobin and 28-day mortality in septic patients: secondary data mining using the MIMIC-IV database

Chen

Zhang

et al. 2023

BMC Infect Dis

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Background Previous studies found minimal evidence and raised controversy about the link between hemoglobin and 28-day mortality in sepsis patients. As a result, the purpose of this study was to examine the association between hemoglobin and 28-day death in sepsis patients by analyzing the Medical Intensive Care IV (MIMIC-IV) database from 2008 to 2019 at an advanced medical center in Boston, Massachusetts. Methods We extracted 34,916 sepsis patients from the MIMIC-IV retrospective cohort database, using hemoglobin as the exposure variable and 28-day death as the outcome variable, and after adjusting for confounders (demographic indicators, Charlson co-morbidity index, SOFA score, vital signs, medication use status (glucocorticoids, vasoactive drugs, antibiotics, and immunoglobulins, etc.)), we investigated the independent effects of hemoglobin and 28-day risk of death by binary logistic regression as well as two-piecewise linear model, respectively. Results Hemoglobin levels and 28-day mortality were shown to be non-linearly related.The inflection points were 104 g/L and 128 g/L, respectively. When HGB levels were between 41 and 104 g/L, there was a 10% decrease in the risk of 28-day mortality (OR: 0.90; 95% CI: 0.87 to 0.94, p-value = 0.0001). However, in the range of 104–128 g/L, we did not observe a significant association between hemoglobin and 28-day mortality (OR: 1.17; 95% CI: 1.00 to 1.35, P value = 0.0586). When HGB was in the range of 128–207 g/L, there was a 7% increase in the risk of 28-day mortality for every 1 unit increase in HGB (OR: 1.07; 95% CI: 1.01 to 1.15, P value = 0.0424). Conclusion In patients with sepsis, baseline hemoglobin was related to a U-shaped risk of 28-day death. When HGB was in the range of 12.8–20.7 g/dL, there was a 7% increase in the risk of 28-day mortality for every 1 unit increase in HGB.

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Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets

Wang

Jiang

et al. 2023

European Journal of Pharmaceutics and Biopharmaceutics

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Kinetic studies on oxygen releasing of HBOC and red blood cells as fluids and factors affecting the process

Cited by 4 publications

References 12 publications

A Novel Cross-Linked Hemoglobin-Based Oxygen Carrier, YQ23, Extended the Golden Hour for Uncontrolled Hemorrhagic Shock in Rats and Miniature Pigs

A Novel Cross-Linked Hemoglobin-Based Oxygen Carrier, YQ23, Extended the Golden Hour for Uncontrolled Hemorrhagic Shock in Rats and Miniature Pigs

The correlation of hemoglobin and 28-day mortality in septic patients: secondary data mining using the MIMIC-IV database

Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets

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