Kinetical Release Study of Copper Ferrite Nanoparticle Incorporated on PCL/Collagen Nanofiber for Naproxen Delivery

Abstract

Nanofiber has become one of tissue engineering examples and has extensive application on medical field, particularly as a wound healing and wound dressing. In this research, nanofiber composite based on polycaprolactone and collagen was successfully obtained via electrospinning process and further developed as host of naproxen as anti-inflammatory agents. Addition of copper ferrite (CuFe 2 O 4 ) nanoparticles on the nanocomposite becomes an advance part on this study to control of naproxen release. Several characterizations were furnished to prove the design composite nanofiber and its drug release analysis performed to find out the kinetic model and naproxen release mechanism from nanofibers. CuFe 2 O 4 nanoparticles have potential to be used to control naproxen release in nanofiber that lead to decrease level of drug released, where mostly follow the Korsmeyer-Peppas model. The release of naproxen was certainly influenced by pH value, in which the drug was easier to release on base, instead of acid or neutral condition. Varied naproxen and nanoparticle compositions were prepared to reach optimum formulation of the release. This study provides fundamental data for the effect of magnetic nanoparticle on drug release process.

Polyester-releasing sesamin by electrospinning technique for the application of bone tissue engineering

“…Moreover, Armedya et al also studied naproxen’s kinetic release from copper ferrite nanoparticles incorporated on PCL/collagen nanofiber. They reported that the release profile was fitted to the Korsmeyer-Peppas model and the release mechanism was a combination of Fickian diffusion and swelling [ 32 ]. Furthermore, Huo et al prepared PCL/collagen nanofibers containing artemisinin (ATR) for transdermal drug delivery system that showed the release of ART from the PCL/Col nanofibers followed the Korsmeyer-Peppas model.…”

Naproxen release from carbon dot coated magnetite nanohybrid as versatile theranostics for HeLa cancer cells

“…The NAP concentration contained in the Fe 3 O 4 @CDs-NAP was calculated by matching the maximum absorbance of NAP with the original standard curve at 330.5 nm. 53 …”

“…It is well known that CDs exhibited excellent biocompatibility and non-toxic features. 68 In the nanohybrid design, even Fe 3 O 4 and other metal ferrites claimed also have low toxic effects; 52,53,69 CDs acting like a cover on the surface of magnetite nanoparticles would possibly prevent toxic reactions between the nanoparticles and the cellular system. Moreover, the half-maximal cytotoxic concentration (CC 50 ) of Fe 3 O 4 @CDs also supported this statement in proving the nontoxic property of the nanohybrid, even at a concentration as high as 17 671.5 ± 1742.6 mg mL −1 (showed on Fig.…”

Naproxen release behaviour from graphene oxide/cellulose acetate composite nanofibers

“…16 CA is also well-used in various applications because of its excellent mechanical properties and compatibility, such as in laminates, fiber adhesives, and films. 8,12,14,17 CA nanofibers also have high potential for use in bone regeneration, 18 gas sensors, 19 supercapacitors, 20 filtration, 21 and drug delivery. 22 The preparation of CA nanofibers using the coaxial electrospinning method has several advantages, such as the controlled and continuous release of drugs over a period and administration of multiple drugs.…”

“… 11 The characteristics, composition and formulation of the materials in wound dressings influence the effectiveness of wound healing. 12 Wound management systems containing drugs can act as drug delivery systems and affect the healing process precisely. Development of transdermal delivery systems took a big step forward by applying nanofibers to control drug movement and systemic delivery.…”