Kinetics and binding properties of cloramphenicol imprinted polymers

Synthesis of core–shell magnetic molecularly imprinted polymers and detection of sildenafil and vardenafil in herbal dietary supplements

“…6b). The broad applicability of the FI to noncovalent MIPs has been demonstrated recently [34][35][36].…”

Tailor-made molecularly imprinted polymers for dimethoate and deltamethrin recognition: synthesis, characterization and chromatographic evaluation

“…In order to evaluate the nature of the binding sites and cognizant of the fact that under non-covalent imprinting conditions, the resulting MIPs contain a heterogeneous mixture of cavities of varying affinity for the guest molecules, we have estimated the sorption capacity and equilibrium isotherm for the MIPs in this study, using Freundlich's isotherm (Eq. 1) as it is an empirical power function for non-ideal sorption on heterogeneous surfaces [4,[39][40][41]. where B is the amount of template bound to the polymer, C is the amount of free template in solution after equilibrium, a is a Freundlich adsorption coefficient related with the binding affinity and m is a Freundlich constant which represents the heterogeneity index and varies from 0 to 1 (values approaching 0 indicate increasingly heterogeneity and 1 is homogeneous).…”

“…The heterogenous nature of the polymer's binding sites diminishes the ability of the MIPs in almost every analytical application and, in particular, on chromatographic applications contributing to the broadening and asymmetry of the peaks. Experimentally, the plot of logB vs. logC was applied to generate the intercept value of a and the slope of m by linear regression, assuming an exponential decaying sorption site energy distribution [39,40]. In Table 2 are summarized the experimental binding data relative to FI obtained for the MIPs studied in this work.…”

Magnetic molecularly imprinted nanoparticles based on dendritic-grafting modification for determination of estrogens in plasma samples

“…The weighted average affinity constant (K K min −Kmax ) and number of binding sites (N K min −Kmax ) for the polymers was calculated using Eqs. (3) and (4) [29][30][31]. The calculated results were listed in Table 1.…”