Kinetics of coacervation transition versus nanoparticle formation in chitosan–sodium tripolyphosphate solutions

Kaloti, Mandeep; Bohidar, H. B.

doi:10.1016/j.colsurfb.2010.07.006

Cited by 80 publications

(38 citation statements)

References 30 publications

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“…The method described by Kaloti and Bohidar ( 2010 ) can be taken as a good example for drug loading and release for chitosan nanoparticles. In this study, cycloheximide, which is a hydrophobic drug that is soluble in chloroform, was used and incubation was done.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Chitosan Nanoparticles: Preparation, Characterization, and Applications

Perera

Rajapakse

2013

Seafood Processing by-Products

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Section: Biomedical Applicationsmentioning

confidence: 99%

Chitosan Nanoparticles: Preparation, Characterization, and Applications

Perera

Rajapakse

2013

Seafood Processing by-Products

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“…Several methods have been employed for the production of chitosan particles, including ionotropic gelation (Bokharaei et al 2011;Rampino et al 2013), spray drying (Li et al 2010), coacervation (Kaloti and Bohidar 2010) and emulsification (Sun et al 2010). Among these methods, the ionotropic gelation is based on electrostatic interaction between the amine group of chitosan and the negatively charged group of a polyanion (Hudson and Margaritis 2014;Nagpal et al 2010), such as pentasodium tripolyphosphate (Li et al 2010;Shu and Zhu 2002), alginate (Elzatahry et al 2009), hyaluronic acid (Oyarzun-Ampuero et al 2009), glutaraldehyde, glyoxal and ethylene glycol diglycidyl ether (Akbuga and Durmaz 1994).…”

Section: Introductionmentioning

confidence: 98%

Chitosan Cross-Linked Pentasodium Tripolyphosphate Micro/Nanoparticles Produced by Ionotropic Gelation

Severino

Silva

et al. 2014

Sugar Tech

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Chitosan cross-linked pentasodium tripolyphosphate particles were produced by ionotropic gelation. The aim of this study was to evaluate the influence of the molar mass and deacetylation degree of chitosan and of the concentration of pentasodium tripolyphosphate in the production of chitosan micro/nanoparticles. The obtained charge ratio (R±), mean particle size, surface electrical charge, polydispersity index, and tendency of particle aggregation were selected as dependent variables. Results demonstrated that stable particles exhibited a high zeta potential value, between ?62 and ?68 mV. Particles were produced in different size ranges controlling the R± between the positively charged chitosan and negatively charged pentasodium tripolyphosphate. Chitosan micro/ nanoparticles were successfully prepared via the ionic gelation method controlling R±, therefore the association of an active ingredient to a micro/nanoparticle allows the molecule to intimately interact with specific structures, to overcome barriers and to prolong its residence time in the target. Chitosan cross-linked pentasodium tripolyphosphate particles are expected to be a good approach for active ingredients formulation in the agrofood sector and related industries.

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“…Compared to chemical cross-linking methods, the physical cross-linking between cation and anion is reversible and less toxic. Tripolyphosphate (TPP) is commonly used to form nanoparticles with chitosan (Tripathy et al 2012;Kaloti and Bohidar 2010). The particle size and zeta potential of chitosan-TPP nanoparticles increased with the increase of chitosan concentration.…”

Section: As the Carrier Of Nanoparticlesmentioning

confidence: 98%

Drug Delivery Applications of Chitosan and its Derivatives

Zhang

Mao

2015

Excipient Applications in Formulation Design and Drug Delivery

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The development of drug delivery systems always goes hand in hand with the advancement of material science. The novel synthetic or natural functional materials provide opportunities to design optimal drug delivery systems. Among these, chitosan and its derivatives exhibit excellent application future because of its prominent characteristics. In this chapter, research progress of chitosan and its derivatives for drug delivery, from structure to properties, from properties to its application were overviewed. The physicochemical properties, biological properties, biodegradability, safety evaluation and structure modification of chitosan were introduced. Furthermore, applications of chitosan and its derivatives in drug delivery including as the carrier of nanoparticles and microparticles, as coating material, as matrix of hydrogels, films and sustained release tablets, as stabilizers, as absorption enhancers, were discussed. Finally, the applications of chitosan and its derivatives in different administration routes, and their advantages for gene, protein and vaccine delivery, were reviewed. The numerous successful studies on exploitation and application of chitosan and its derivatives showed promising application future of these materials in drug delivery.

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Kinetics of coacervation transition versus nanoparticle formation in chitosan–sodium tripolyphosphate solutions

Cited by 80 publications

References 30 publications

Chitosan Nanoparticles: Preparation, Characterization, and Applications

Chitosan Nanoparticles: Preparation, Characterization, and Applications

Chitosan Cross-Linked Pentasodium Tripolyphosphate Micro/Nanoparticles Produced by Ionotropic Gelation

Drug Delivery Applications of Chitosan and its Derivatives

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