Kinetics of emitted mass—A study with three dry powder inhaler devices

Behara, Srinivas Ravindra Babu; Kippax, Paul; Larson, Ian; Morton, David Alexander Vodden; Stewart, Peter

doi:10.1016/j.ces.2011.07.029

Cited by 23 publications

(11 citation statements)

References 11 publications

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“…ED depicts the total drug emptying capability from the device, however, it is an end-point measurement and gives no information on time dependant aerosolisation characteristics. When considered together with CEM, these two in-vitro performance metrics are essentially a measure of powder fluidisation and entrainment but do not provide information on the degree of particle deagglomeration (or, in the case of ED, drug de-agglomeration) (Behara et al, 2011).…”

Section: Drug Deliverymentioning

confidence: 99%

An insight into powder entrainment and drug delivery mechanisms from a modified Rotahaler®

Sim¹,

Margo²,

Parks³

et al. 2014

International Journal of Pharmaceutics

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Section: Drug Deliverymentioning

confidence: 99%

An insight into powder entrainment and drug delivery mechanisms from a modified Rotahaler®

Sim¹,

Margo²,

Parks³

et al. 2014

International Journal of Pharmaceutics

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“…Therefore, the major objective of the present study was to assess the aerosol generation mechanisms of capsule and the effect of device resistance and flow rate on the powder deagglomeration process by adopting a rapid screening method to characterize the release behavior of pharmaceutical powder formulation. The approach used in this study is similar to that described by Behara et al (2011), however, with attention concentrated on the influence of capsule on powder dispersion behavior.…”

Section: Introductionmentioning

confidence: 99%

“…However, details of the powder release behavior cannot be established from these analytical techniques and therefore the kinetics of powder deagglomeration is poorly understood (de Boer et al 2002). Real-time laser diffraction analysis, which provides a direct way of capturing the plume duration and powder emptying behavior, can be used to obtain fundamental details of powder deagglomeration and powder release as reported by a number of authors (Kippax and Morton 2008;Behara et al 2011;Behara et al 2012). Empirically, it is known that the capsule significantly improves the powder deagglomeration of pharmaceutical aerosols (Chew et al 2002).…”

Section: Introductionmentioning

confidence: 99%

An Investigation into the Powder Release Behavior from Capsule-Based Dry Powder Inhalers

Huynh

Chen

Fletcher

et al. 2015

Aerosol Science and Technology

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A methodology for studying the deagglomeration performance and emptying behavior of micronized mannitol powder from two commercial capsule-based dry powder inhalers (DPIs), the lowand high-resistance RS01 Ò , is presented. Mathematical modeling played a key role in the interpretation of the powder release behavior from these two DPI systems. Non-linear regression models, which were characterized from the aerosol obscuration versus time profiles obtained from laser diffraction particle sizing data, were used to estimate rate constants for emptying of mannitol powder. The effects of device resistance and associated pressure drops, sampling flow rate, rates of powder emptying, and the presence of capsule on the dispersion characteristics were studied. The presence of a capsule significantly improved the aerosolization performance of mannitol powder from both inhalers, which may be due to the extended powder-air-device interactions within the device. It is important to consider the stochastic nature of movement and physical state of the capsule when assessing the aerosolization mechanisms and dispersion performance from these complex delivery systems. The methodology set out in this study has the capacity to provide a greater level of detail in the study of aerosol plume characteristics from capsule-based DPIs.

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“…The cumulative fine particle masses were determined by the method outlined in Behara et al, 2011a. Firstly, using the data inherent in the particle sizing of the aerosol plume, a measure of the extent of de-agglomeration (i.e.…”

Section: Cumulative Fine Particles Massmentioning

confidence: 99%

“…Kinetic studies have been reported on the de-agglomeration of particles of size range of 250-1000 μm (deVilliers, 1997), the detachment of drug from carriers in carrier based formulations (de Boer et al, 2004) and the de-agglomeration of particles in suspensions (Ding and Pacek, 2008). Our group has recently reported the kinetics of powder de-agglomeration where the rate of de-agglomeration of two cohesive powders salbutamol sulphate (SS) and Lactohale 300 were studied from three different inhalers (Behara et al, 2011a). The de-agglomeration rate constants (k d ) of both SS and Lactohale 300 were estimated and were related to the material, air flow rate and device.…”

Section: Introductionmentioning

confidence: 99%

The Kinetics of De-agglomeration of Magnesium Stearate Dry-Coated Salbutamol Sulphate Powders

Shi

Das

Morton

et al. 2015

KONA

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The objective was to investigate the effect of dry coating of salbutamol sulphate (SS) with magnesium stearate (MgSt) on the kinetics of powder de-agglomeration. The relative de-agglomeration of the MgSt coated SS powders was higher than uncoated SS at all air flow rates; the SS coated with 2 % MgSt showed the highest extent of de-agglomeration (> 5 % MgSt coated SS > 1 % MgSt coated SS). Rate of de-agglomeration was described by a cumulative de-agglomerated versus time profile. Profiles fitted a mono-exponential model and the deagglomeration rate constant (k d ) was estimated. No significant differences existed between any of the uncoated and coated powders. The significance of this study relates to the improved aerosolization and de-agglomeration performance of the MgSt coated SS powders with optimum performance of 2 % MgSt coated SS. More significant is the finding that no change existed in de-agglomeration rate constants between the coated and uncoated powders, with the potential implications that their aerosol plume concentration and deposition patterns were similar.

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Kinetics of emitted mass—A study with three dry powder inhaler devices

Cited by 23 publications

References 11 publications

An insight into powder entrainment and drug delivery mechanisms from a modified Rotahaler®

An insight into powder entrainment and drug delivery mechanisms from a modified Rotahaler®

An Investigation into the Powder Release Behavior from Capsule-Based Dry Powder Inhalers

The Kinetics of De-agglomeration of Magnesium Stearate Dry-Coated Salbutamol Sulphate Powders

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