Kinetics of T-Lymphocyte Subsets and Posttransplant Opportunistic Infections in Heart and Kidney Transplant Recipients

Calarota, Sandra A.; Zelini, Paola; Silvestri, Annalisa De; Chiesa, A.; Comolli, Giuditta; Sarchi, Eleonora; Migotto, C.; Pellegrini, Carlo; Esposito, Pasquale; Minoli, Lorenzo; Tinelli, Carmine; Marone, Piero; Baldanti, Fausto

doi:10.1097/tp.0b013e318239e90c

Cited by 54 publications

(51 citation statements)

References 44 publications

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“…The most common OI after RTx was CMV related, accounting for approximately half of these infections; this finding is supported by other studies (26)(27)(28). Urinary tract infections accounted for the majority of SIs in our study and have also been described by previous studies (29)(30)(31).…”

Section: Discussionsupporting

confidence: 81%

Uremia-Associated Premature Aging of T Cells Does Not Predict Infectious Complications After Renal Transplantation

Dedeoğlu

Meijers

Klepper

et al. 2016

American Journal of Transplantation

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Patients with end-stage renal disease have prematurely aged T cell systems. We tested whether T cell aging parameters were associated with the risk of infections after renal transplantation (RTx). We studied 188 patients over 1 year. Peripheral T cells were analyzed before and at 3 and 6 mo after RTx for frequency of recent thymic emigrants, relative telomere length and differentiation status. These parameters were related to the occurrence of opportunistic and serious infections. Overall, 84 patients developed an infection. In this group, 50 developed an opportunistic infection and 53 developed a serious infection. T cell aging parameters assessed before RTx were not associated with infection risk. The memory T cells showed a decrease within the first 3 mo in both groups (p < 0.001). The CD4 + memory T cells increased between 3 and 6 mo within the infection group (p = 0.015). The number of CD8 + memory T cells increased in both groups (p < 0.001) but reached baseline levels only in the infection group. In the infection group, the CD8 + CD28null T cell percentage increased between 3 and 6 mo (p = 0.024), tending to be higher than at baseline (p = 0.061). These differences in post-RTx dynamics resulted from infections. Parameters of uremia-associated premature aging of peripheral T cells do not predict posttransplant infections.

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Section: Discussionsupporting

confidence: 81%

Uremia-Associated Premature Aging of T Cells Does Not Predict Infectious Complications After Renal Transplantation

Dedeoğlu

Meijers

Klepper

et al. 2016

American Journal of Transplantation

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“…Calarota et al 26 regularly assessed the CD4 þ and CD8 þ T-cell numbers during the first 8 months after kidney and heart transplantation and reported that those patients who developed opportunistic infections had lower counts as compared with those without. Various authors as well have consistently shown that the risk of various intercurrent infections after kidney transplantation is increased in recipients with low CD4 þ T-cell counts.…”

Section: Discussionmentioning

confidence: 99%

Study of intercurrent infection pattern in hepatitis C seropositive renal transplant recipients, relationship with T-cell function

et al. 2016

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Background:We assessed the effect of hepatitis C seropositivity on the percentage of various Tcells in living donor renal transplant recipients (LDRTRs) and their association with intercurrent infections post renal transplantation (post-Tx). Methods: One hundred and thirty-three matching LDRTRs [A (seronegative) (68 patients) and B (seropositive) (65 patients) by ELISA] were studied prospectively 10 days, 6 months and 12 months post-Tx for intercurrent infections, acute rejection and T-cell% by flow cytometry.þ , CD4/CD8 were significantly higher 10 days post-Tx in Group B compared to Group A, p < 0.001. A significant increase in CD8% was seen 6-month post-Tx among Group B compared to Group A. No difference was detected between groups in (CD4 þ , CD8 þ , CD4/CD8, CD3-CD16/65

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“…Few studies have evaluated the kinetics of T-lymphocyte subsets and their association with infections after transplantation [3][4][5][6]. Patients with low CD4 + T-cell counts at 1 month after heart transplantation showed poor recovery of CD4 + T cells and developed OI, while low (and poor recovery of) CD8 + T-cell counts were associated with the risk of OI in kidney transplant recipients (KTR) [4]. Similarly, a more recent study has confirmed that low T-cell counts at month 1 posttransplant predicts the subsequent occurrence of OI in KTR [6].…”

Section: Enumeration Of T-cell Subsetsmentioning

confidence: 99%

Approaches for monitoring of non virus-specific and virus-specific T-cell response in solid organ transplantation and their clinical applications

Calarota

Aberle

Puchhammer‐Stöckl

et al. 2015

Journal of Clinical Virology

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Kinetics of T-Lymphocyte Subsets and Posttransplant Opportunistic Infections in Heart and Kidney Transplant Recipients

Abstract: Determination of T-lymphocyte subsets is a simple and effective parameter to identify patients at risk of developing OIs.

Cited by 54 publications

References 44 publications

Uremia-Associated Premature Aging of T Cells Does Not Predict Infectious Complications After Renal Transplantation

Uremia-Associated Premature Aging of T Cells Does Not Predict Infectious Complications After Renal Transplantation

Study of intercurrent infection pattern in hepatitis C seropositive renal transplant recipients, relationship with T-cell function

Approaches for monitoring of non virus-specific and virus-specific T-cell response in solid organ transplantation and their clinical applications

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