An increase in complication of decision making process regarding the enterprises localization implies the necessity to search for new tools facilitating monitoring of changes in an enterprise environment and a reduction of potential location pool. This especially concerns large-scale enterprises with diversified spatial structure. Currently, an enterprise localization analysis constitutes not only an element of strategic management of enterprises, but it should also be a subject of activity of regions willing to look for investors in an active manner. On the one side, business entities search for locations that meet their needs. On the other side, regions offer investment areas to accelerate regional development. Local authorities do not decide on an enterprise localizations, but they can create operating conditions to a certain extent (e.g. equipment with technical infrastructure or labor force for entrepreneur and investor's needs). Therefore, there is a need for application of new solutions or at least modification of localization management methods. Here, we present the study on an application of modified McKinsey matrix for spatial analysis using an original concept of regional strategic groups. The regional strategic groups constitute the cluster of regions with similar sector attractiveness, as well as competitive position or potential. The objective of the study was to create a new methodological model in an enterprise localization analysis, based on regional strategic groups. Also, we demonstrated application options of the proposed tool in management of enterprise strategic options for automotive sector in NUTS 2 level regions in the EU.