Kombination von DC, GC (OV1 und OV17) und HPLC (RP18) zur schnellen Erkennung von Arzneimitteln, Rauschmitteln und verwandten Verbindungen

Daldrup, Th.; Susanto, F.; Michalke, P.

doi:10.1007/bf00466076

Cited by 116 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further "general unknown" screening for acid-neutral and basic drugs was performed after alkaline or acid liquid-liquid or SPE-extraction by TLC [13] GC, GC/MS [14], and HPLC [15].…”

Section: Systematic Toxicological Analysismentioning

confidence: 99%

Death after excessive propofol abuse

Iwersen‐Bergmann

Rösner

Kühnau

et al. 2001

International Journal of Legal Medicine

View full text Add to dashboard Cite

“…Further "general unknown" screening for acid-neutral and basic drugs was performed after alkaline or acid liquid-liquid or SPE-extraction by TLC [13] GC, GC/MS [14], and HPLC [15].…”

Section: Systematic Toxicological Analysismentioning

confidence: 99%

Death after excessive propofol abuse

Iwersen‐Bergmann

Rösner

Kühnau

et al. 2001

International Journal of Legal Medicine

View full text Add to dashboard Cite

“…The determination of the above compounds has been essentially performed by gas liquid chromatography (1,Z) or reversed-phase high performance liquid chromatography (RP-HPLC) (1,(3)(4)(5). The major problem associated with the analysis of basic drugs by RP-HPLC is peak tailing caused by ionic interactions between the analytes and free silanol groups of the packing material.…”

Section: Simultaneous Determination Of Ephedrine and 2-imidazolines Imentioning

confidence: 99%

Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc

Orsi¹,

Gagliardi²,

Cavazzutti³

et al. 1995

Journal of Liquid Chromatography

View full text Add to dashboard Cite

A simpleIrapidl and accurate method for the determination of naphazoline, oxymetazoline, xylometazoline, and ephedrine in rhological solutions using reversed-phase HPLC was developed. It involves the use of alumina coated with polybutadl7ne as the stationary phase, acetonitrile-aqueous 10 M NaOH (10:90) as the initial mobile phase with a linear gradient from 10 to 80% acetonitrile in 25 min, and detection at 224 nm. The only sample preparation is its dilution with water. Linearity and precision of the method have been assessed. The assay results obtained for various formulations were in agreement with the declared amounts.

show abstract

“…Neben der Dünn-schicht-und der Gaschromatographie bietet die Hochleistungs-Flüssigchromatographie (HPLC) [l, 2] ein breites Anwendungsfeld. Vorwiegend zum Einsatz kommt die reversed-phase-HPLC, wobei durch Variation der stationären und der mobilen Phase nahezu alle Trennprobleme zu bewerkstelligen sind [3,4]. Die Detektion erfolgt vorwiegend durch Lichtabsorption im ultravioletten Teil des Spektrums.…”

Section: Ie Qualitative Und Quantitative Bestimmung Vonunclassified

Medikamentenbestimmung mit Elektrospray Tandem-Massenspektrometrie. Drug Monitoring by Electrospray Tandem Mass Spectrometry

Huesgen¹,

Roos²,

Kinkeldei³

2000

LaboratoriumsMedizin

View full text Add to dashboard Cite

Zusammenfassung: Die Hochleistungs-Flüssigchro-matographie (HPLC) ist ein universelles Werkzeug für die Bestimmung von Drogen und Medikamentenspiegeln im Blut. Die Detektion des AnaJyten erfolgt vorwiegend durch Lichtabsorptions-oder Fluoreszenzmessung. Einige Medikamente weisen jedoch keinen Chromophor auf, oder die molaren Absorptionskoeffizienten sind sehr klein. Sie entziehen sich so einer empfindlichen Bestimmung. Die Tandem-Massenspektrometrie (LC-MS/MS) ist solchen Einschränkungen nicht unterworfen. Dies wird an den Bestimmungen von Gabapentin, Vigabatrin, Amantadin und Haloperidol demonstriert. Die Proben Vorbereitung ist ungewöhnlich einfach und schnell. Es lassen sich auch große Serien kostengünstig in kurzer Zeit analysieren. Schlüsselwörter: Spektrumanalyse, Massen-Methodik; Gabapentin/Serum; Vigabatrin/Serum; Amantadin/Serum; Haloperidol/Serum. Summary:High performance liquid chromatography is a universal tool for the quantitation of drugs or medications in blood. Light absorption and fluorescence is mostly used for detection. Some drugs do not have chromophors or have low molar absorptivities. So quantitation is difficult at low concentrations. Tandem Mass Spectrometry (LC-MS/MS) does not have these restrictions. We demonstrate the usefulness of LC-MS/MS in the quantitation of Gabapentin, Vigabatrin, Amantadine and Haloperidol. Sample preparation is simple and fast. Large sample series can be analyzed cost-effectively and within a short time.

show abstract

Kombination von DC, GC (OV1 und OV17) und HPLC (RP18) zur schnellen Erkennung von Arzneimitteln, Rauschmitteln und verwandten Verbindungen

Cited by 116 publications

References 2 publications

Death after excessive propofol abuse

Death after excessive propofol abuse

Simultaneous Determination of Ephedrine and 2-Imidazolines in Pharmaceutical Formulations by Reversed-Phase Hplc

Medikamentenbestimmung mit Elektrospray Tandem-Massenspektrometrie. Drug Monitoring by Electrospray Tandem Mass Spectrometry

Contact Info

Product

Resources

About