This study aims to find the correlation between the meaning of life and resilience in adolescents at the Bani Adam-As orphanage. This study uses a quantitative approach. The subjects in this study were orphanage adolescents aged 16-18 years. This study used purposive sampling as the sampling technique, which technique is based on specific considerations, so the sample amount to 52 adolescents. The hypothesis in this study is that there is a positive correlation between the meaning of life and resilience. The data collection technique used the Likert scale. Data analysis using product moment analysis. Based on the analysis that has been done, there is a coefficient value (Rxy) of 0.693 with p = 0.000 <0.050. The result shows that the hypothesis in this study is "accepted", means that there is a positive and significant correlation between the meaningfulness of life and resilience in adolescents, which shows that the higher the meaningfulness of life, the higher the resilience, and vice versa, the lower the meaningfulness of life, the lower the resilience. The coefficient of determination of the correlation is r₂ = 0.480, which means that the meaningfulness of life contributes to resilience by 48 percent, while the rest is determined by other aspects not examined in this study. The meaning of life in this study is high because (hypothetical mean = 60 < empirical mean = 71.63), whereas resilience in this study is high because (hypothetical mean = 57.5 < empirical mean = 68, 25).