Korean mistletoe (Viscum album coloratum) extract regulates gene expression related to muscle atrophy and muscle hypertrophy

Jeong, Juseong; Park, Choon-ho; Kim, Inbo; Kim, Young‐Ho; Yoon, Jaemin; Kim, Kwangsoo; Kim, Jong-Bae

doi:10.1186/s12906-017-1575-9

Cited by 9 publications

(10 citation statements)

References 49 publications

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“…Under cachexic conditions, myo-proteins undergo ubiquitin modification by E3 ubiquitin ligases and proteasome-dependent degradation [5,6]. Thus, increased expression of E3 ubiquitin ligases indicate the progress of muscle atrophy accompanied by myofibrillar and intracellular proteins breakdown [17,30]. Bodine et al have shown that MAFbx or MuRF1-deficient mouse can overcome muscle atrophy, whereas MAFbx overexpressing myoblasts exhibit retardation in myotube formation [31].…”

Section: Discussionmentioning

confidence: 99%

A Chalcone from Ashitaba (Angelica keiskei) Stimulates Myoblast Differentiation and Inhibits Dexamethasone-Induced Muscle Atrophy

et al. 2019

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Ashitaba, Angelica keiskei Koidzumi (AK), as a traditional medicine in Korea, Japan, and China, has been known as an elixir of life having therapeutic potential. However, there is no scientific evidence to support that Ashitaba can enhance or maintain muscle strength. To find a new therapeutic agent from the medicinal plant, we evaluated the anti-myopathy effect of chalcones from ethanol extract of AK (EAK) in cellular and animal models of muscle atrophy. To examine anti-myopathy activity, EAK was treated into dexamethasone injected rats and muscle thickness and histopathological images were analyzed. Oral administration of EAK (250 or 500 mg/kg) alleviated muscle atrophic damages and down-regulated the mRNA levels of muscle-specific ubiquitin-E3 ligases. Among ten compounds isolated from EAK, 4-hydroxyderricin was the most effective principle in stimulating myogenesis of C2C12 myoblasts via activation of p38 mitogen-activated protein kinase (MAPK). In three cellular muscle atrophy models with C2C12 myoblasts damaged by dexamethasone or cancer cell-conditioned medium, 4-hydroxyderricin protected the myosin heavy chain (MHC) degradation through suppressing expressions of MAFbx, MuRF-1 and myostatin. These results suggest that the ethanol extract and its active principle, 4-hydroxyderricin from AK, can overcome the muscle atrophy through double mechanisms of decreasing muscle protein degradation and activating myoblast differentiation.

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Section: Discussionmentioning

confidence: 99%

A Chalcone from Ashitaba (Angelica keiskei) Stimulates Myoblast Differentiation and Inhibits Dexamethasone-Induced Muscle Atrophy

et al. 2019

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“…In C2C12 cells, as well as in denervated mice, mistletoe decreased gene expression of Atrogin-1. On the contrary, in C2C12 cells, mistletoe increased mRNA expression of PGC-1α, GLUT-4, and SREBP-1c genes related to the inhibition of muscle atrophy and related to the induction of muscle hypertrophy by regulating the expression of Atrogin-1and Murf1 (Jeong et al 2017). Lim et al (2017) conducted randomized controlled trial confirming that supplementation with Korean mistletoe extract and exercise affects muscle mass and functional capabilities.…”

Section: Activity Against Muscle Declinementioning

confidence: 94%

“…Supplementation with mistletoe might be effective against age-related decline in muscle mass (Table 2). An in vitro study showed that an aqueous extract of Korean mistletoe caused higher phosphorylation of AKT in C2C12 cells (mouse myoblast cell line), suggesting that mistletoe has an effect on the regulation of the muscle mass through the activation of the AKT/mTOR (protein kinase B/ mammalian target of rapamycin) signalling pathway (Jeong et al 2017) (Fig. 9).…”

Section: Activity Against Muscle Declinementioning

confidence: 99%

Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action

2020

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Boiss. Mistletoe is a semi-parasitic evergreen shrub, which means it depends on having water and some nutrients supplied from another plant (host tree) while it produces carbohydrates in a process of photosynthesis. Viscum species inhabit many types of wooded habitats and parasitize both deciduous and coniferous trees (Bussing 2000). For clinical applications, the most popular species are mistletoe parasitizing fir, maple, almond, birch, hawthorn, ash, apple, pine, poplar, oak, willow, lime and elm (Kienle et al. 2011). Viscum species have been used in the traditional medicine of Europe for centuries. Hippocrates used mistletoe to treat diseases of the spleen and complaints associated with menstruation, while Pliny the Elder used it to treat epilepsy, infertility and ulcers. In the Middle Ages, Paracelsus recommended mistletoe as a treatment for epilepsy. Hildegard von Bingen described mistletoe as a treatment for diseases of the spleen and liver. Mistletoe was also applied for deworming children, to treat labour pains, gout, affections of the lungs and liver, leprosy, mumps, fractures and hepatitis. During the eighteenth century, mistletoe was applied for "weakness of the heart" and oedema (Bussing 2000). By the end of the nineteenth century, mistletoe was rejected by scientists as a folklore remedy. The scientific interest on mistletoe was awakened in the twentieth century, as Gaultier investigated the effect of oral or subcutaneous Abstract Mistletoe has been used as treatment of many diseases in traditional and folk medicine. To date, anticancer, immunomodulatory, cardiac, antidiabetic, hepatoprotective, neuropharmacological, antibacterial and antifungal properties of mistletoe extracts have been studied the most. In this review, we summarized in vitro and in vivo studies on the pharmacological activity of Viscum species. Furthermore, we proposed the possible mechanisms of action of this herb, which might include many signalling pathways. Mistletoe could regulate either similar or different targets in various pathways that act on membrane receptors, enzymes, ion channels, transporter proteins and transcriptional targets. Still, pharmacological activities of mistletoe have been investigated mainly for crude extracts. It is a new field for scientists to determined which chemical compounds are responsible for the individual biological activities of mistletoe and how these activities are achieved. As a result, mistletoe might become a source of new complementary therapies supporting the treatment of many diseases.

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“…A 4-week supplementation of KME can improve skeletal muscle weight and strength, in denervation-induced atrophy mice. The expression of the skeletal muscle protein degradation genes (Murf1 and Atrogin1) were downregulated by KME treatment, hinting at a possible mechanism in preventing skeletal muscle wasting (Jeong et al, 2017).…”

Section: Anti-atrophymentioning

confidence: 96%

The Aging of Skeletal Muscle and Potential Therapeutic Effects of Extracts from Edible and Inedible Plants

Alfarafisa

Kitaguchi

Yabe

2020

RAS

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Sarcopenia is a degenerative phenomenon, common in elderly populations. As humans age, they are likely to experience skeletal muscle weakness and atrophy; however, unfortunately, there is still no effective treatment for sarcopenia. The health-promoting potential of plant-based foods is associated with the presence of bioactive components. This article reviews information on bioactive plant compounds which may affect skeletal muscle health, particularly with respect to therapeutic approaches to sarcopenia. In general, plant products can be categorized into two main groups, based on their general status in the human diet: inedible or edible. Investigations suggest that bioactive compounds from both groups show the potential to prevent the development of sarcopenia, in several ways, including anti-atrophy, prevention of oxidative damage, enhanced myogenesis, and anti-inflammatory activity. Each of these agents has been shown to suppress one or more of the signs of sarcopenia, and restore health to muscle, in the patient (in vivo) or in tissue culture (in vitro). The potential use of plant bioactive compounds as therapy for sarcopenia is worthy of further study.

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Korean mistletoe (Viscum album coloratum) extract regulates gene expression related to muscle atrophy and muscle hypertrophy

Cited by 9 publications

References 49 publications

A Chalcone from Ashitaba (Angelica keiskei) Stimulates Myoblast Differentiation and Inhibits Dexamethasone-Induced Muscle Atrophy

A Chalcone from Ashitaba (Angelica keiskei) Stimulates Myoblast Differentiation and Inhibits Dexamethasone-Induced Muscle Atrophy

Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action

The Aging of Skeletal Muscle and Potential Therapeutic Effects of Extracts from Edible and Inedible Plants

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