Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: An atopic dermatitis model

Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model

“…TNCB was used to induce AD-like skin lesions in NC/Nga mice as previously described (Lee and Cho, 2011). The abdomens were sensitized epicutaneously by applying 150 ml of 5% TNCB dissolved in ethanol/acetone mixture (4:1).…”

“…The severity of AD-like lesions was evaluated by scoring the clinical signs using digital photographs as in our previous study (Lee and Cho, 2011). The total clinical severity score was defined as the sum of each score grades: 0 (none), 1 (mild), 2 (moderate) and 3 (severe) for each of the four manifestations: (1) erythema/ hemorrhage, (2) edema, (3) excoriation/erosion, and (4) scaling/ dryness.…”

“…KRG was further studied to have anti-allergic effects. (Bae et al, 2006;Matsuda et al, 1990;Park et al, 2003) Recently, we have demonstrated that oral administration of KRG could inhibit the inflammation of AD-like skin lesions in NC/Nga mice by suppressing LCs, Th1 related cytokines, and regulatory T (Treg) cells (Lee and Cho, 2011). To date, there have been no studies to assess the preventive effects of oral KRG administration and its mechanism on early lesions in the AD murine model.…”

Renoprotective effect of red ginseng in gentamicin-induced acute kidney injury

“…Active component of RGE was analyzed by high-performance liquid chromatography. 19 RGE used in this experiment contains major ginsenoside-Rb1: 13.9%, -Rb2: 14.4%, -Rc: 6.1%, -Rd: 13.9%, -Re: 4.7%, -Rf: 11.5%, -Rg1: 2.6%, -Rg2: 0.69%, -Rg3: 2.8%, and other minor ginsenosides. Mitochondria-target ubiquinone (MitoQ) is a kind gift from Dr Michael P Murphy (Medical Research Council Dunn Human Nutrition Unit, UK).…”

Protective Effect of Korean Red Ginseng Extract on the Infections by H1N1 and H3N2 Influenza Viruses in Mice

“…3,4 Various beneficial pharmacological effects of ginseng or its components have been reported, including anticancer, anti-allergy, antiinflammatory, antifatigue, antistress, and immunomodulatory activities. [5][6][7][8][9][10][11][12][13][14][15][16] In clinical studies, ginseng has been shown to have beneficial effects on improving the survival and the quality of life among breast cancer patients, 17 in a placebocontrolled pilot trial of cancer patients, 18 in patients infected with human immunodeficiency virus, 19,20 and on reducing the occurrence of gastric cancer. 21 Immunomodulatory effects are among the beneficial properties attributed to ginseng extract.…”