L’apport de l’électrorétinographie multifocale dans le suivi des patients traités par hydroxychloroquine

Aliferis, K.; Mermoud, C.; Safran, Avinoam B.

doi:10.1016/j.jfo.2011.03.005

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…These data are consistent with previous reports in the literature,24,27,28 and only one study found an increased latency without reduction in amplitude 29…”

Section: Discussionsupporting

confidence: 93%

Hydroxychloroquine for treatment of rheumatoid arthritis: multifocal electroretinogram and laser flare-cell photometry study

Sebastiani¹,

Fresina²,

Cellini³

et al. 2017

OPTH

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PurposeTo evaluate early changes in multifocal electroretinogram (mfERG) and subclinical aqueous humor flare and cellularity in patients receiving hydroxychloroquine (HCQ) as treatment for rheumatoid arthritis.MethodsTen patients receiving treatment with HCQ and no ophthalmic symptoms were enrolled. After complete ocular examination, mfERG and laser flare-cell photometry were performed. Patients were also divided into two subgroups with HCQ cumulative dose (CD) higher or lower than 500 g. Results obtained were compared with a control group of ten healthy subjects and statistical analysis was performed.ResultsIn patients receiving HCQ treatment, mfERG P1-wave in ring 2 showed a significant reduction in amplitude and a significant increase in latency compared to healthy control subjects, respectively resulting in 1.143 μV vs 1.316 μV (P=0.040) and 38.611 ms vs 36.334 ms (P=0.024). These changes are highly related to CD. Furthermore, when using the laser flare-cell photometry, a significant increase in aqueous humor flare and cellularity was shown in patients with CD higher than 500 g, resulting in a mean value of 14.4 ph/ms compared to 8.1 ph/ms in patients with CD lower than 500 g (P=0.0029). These reports appear highly related to CD (P=0.001). Receiver operating characteristic curve analysis showed mfERG P1-wave amplitude in ring 2 as the most sensitive value in detecting early HCQ-related retinopathy.ConclusionMfERG was shown to be a very sensitive test in detecting early retinal toxicity and should be used for the screening of patients receiving HCQ treatment. Although less sensitive, laser flare-cell photometry can provide further information to evaluate early toxic retinal cell damage.

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“…These data are consistent with previous reports in the literature,24,27,28 and only one study found an increased latency without reduction in amplitude 29…”

Section: Discussionsupporting

confidence: 93%

Hydroxychloroquine for treatment of rheumatoid arthritis: multifocal electroretinogram and laser flare-cell photometry study

Sebastiani¹,

Fresina²,

Cellini³

et al. 2017

OPTH

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“…Improvement in mfERG response occurs along with visual acuity 15. Aliferis et al16 observed that the average implicit times of patients receiving hydroxychloroquine were significantly prolonged, but the amplitudes were not significantly impaired. They presumed that these values do not always change in parallel in toxic maculopathy caused by hydroxychloroquine 16.…”

Section: Discussionmentioning

confidence: 99%

“…Aliferis et al16 observed that the average implicit times of patients receiving hydroxychloroquine were significantly prolonged, but the amplitudes were not significantly impaired. They presumed that these values do not always change in parallel in toxic maculopathy caused by hydroxychloroquine 16. Melles and Marmor17 have recently reviewed ophthalmic studies that assessed hydroxychloroquine-induced retinopathy based on fundus photography and autofluorescence, visual field examination, spectral domain-OCT, and mfERG.…”

Section: Discussionmentioning

confidence: 99%

Assessment of hydroxychloroquine maculopathy after cessation of treatment: an optical coherence tomography and multifocal electroretinography study

Moschos¹,

Nitoda²,

Chatziralli³

et al. 2015

DDDT

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ObjectiveThis study was conducted to evaluate the macular status of patients treated with hydroxychloroquine before and after cessation of treatment.MethodsForty-two patients with systemic lupus erythematosus underwent ocular examination based on visual acuity evaluation, optical coherence tomography retinal thickness measurements, and multifocal electroretinography (mfERG) records at first visit. The tests were repeated 6 months after treatment withdrawal and compared to the findings at their first visit.ResultsMean visual acuity (measured in log minimum angle of resolution) of both eyes was statistically increased after hydroxychloroquine discontinuation (difference in means: 0.06 [P<0.0001] and 0.01 [P=0.003] for the right and left eyes, respectively). Retinal response amplitudes of central and peripheral areas were significantly improved for both eyes. The following values were observed for central responses: the difference in means was −19.9 (P<0.0001) and −13.6 (P<0.0001) for the right eye and the left eye, respectively; for peripheral responses, difference in means was −10.3 (P<0.0001) and −9.5 (P<0.0001) for right eye and left eye, respectively, after the 6-month examination. There were no statistically significant differences in the retinal thickness of patients after cessation of treatment. The visual acuity of the patients was correlated to central and peripheral mfERG responses (r=−0.53 [P<0.0001] and r=−0.53 [P<0.0001], for the right eye and the left eye, respectively).ConclusionThe visual acuity of patients receiving hydroxychloroquine improves along with the amplitudes of the mfERG responses 6 months after discontinuation of the drug, but no difference in retinal thickness is identified.

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Rastreio da Retinotoxicidade pela Hidroxicloroquina

Miranda

Sousa

Telles

et al. 2014

Revista Sociedade Portuguesa De Oftalmologia

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L’apport de l’électrorétinographie multifocale dans le suivi des patients traités par hydroxychloroquine

Abstract: Résumé 7But du travail 91. Introduction 111.1 L'électrorétinogramme multifocal 111.1.

Cited by 3 publications

References 40 publications

Hydroxychloroquine for treatment of rheumatoid arthritis: multifocal electroretinogram and laser flare-cell photometry study

Hydroxychloroquine for treatment of rheumatoid arthritis: multifocal electroretinogram and laser flare-cell photometry study

Assessment of hydroxychloroquine maculopathy after cessation of treatment: an optical coherence tomography and multifocal electroretinography study

Rastreio da Retinotoxicidade pela Hidroxicloroquina

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