L form of bacteria isolated from recurrent aphthous stomatitis lesions

Barile, Michael F.; Graykowski, Edward A.; Driscoll, Edward J.; Riggs, Donald B.

doi:10.1016/0030-4220(63)90416-x

Cited by 80 publications

(25 citation statements)

References 18 publications

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“…The initial L-form isolate from RAS patients was typed as S. sanguis (Barile et al, 1963), but later analysis disclosed that this organism was actually a strain of S. mitis (Hoover and Greenspan, 1983). While some studies have disclosed elevated serum antibody titers to viridans streptococci among RAS patients, other investigations have yielded contradictory results (Barile et al, 1968;Donatsky, 1976).…”

Section: Microbial Aspects Of Rasmentioning

confidence: 90%

Recurrent Aphthous Stomatitis

Porter

Scully

Pedersen

1998

Critical Reviews in Oral Biology & Medicine

252

143

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Section: Microbial Aspects Of Rasmentioning

confidence: 90%

Recurrent Aphthous Stomatitis

Porter

Scully

Pedersen

1998

Critical Reviews in Oral Biology & Medicine

252

143

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“…An overall prevalence of 10-20% has been reported for the general population (Rennie et al, 1985;Scully et al, 2003), with a higher prevalence of RAS (56%) in selected groups, such as university students (Donatsky, 1973). Although hereditary (Ship, 1965;Shohat-Zabarski et al, 1992), dietary (Eversole, 1994), hematologic (Burgan et al, 2006), infectious (Barile et al, 1963;Sun et al, 1996), allergic (Boulinguez et al, 2003) and immunologic (Natah et al, 2000) factors have been implicated, their role as the main etiological factors in the pathogenesis remains to be elucidated. Furthermore, with the dramatic worldwide increase in patients with immuno-suppression caused by medical treatments, systemic diseases, or both, the prevalence of these conditions may be increasing.…”

Section: Introductionmentioning

confidence: 95%

The efficacy of the bioadhesive patches containing licorice extract in the management of recurrent aphthous stomatitis

Moghadamnia

Mina

Khanian

2008

Phytotherapy Research

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This study evaluated the efficacy of licorice bioadhesive hydrogel patches to control the pain and reduce the healing time of recurrent aphthous ulcer.This study was carried out in three episodes of ulcers: in the first episode of ulcer, all 15 patients were asked to record their baseline individual pain level by a visual analog scale. In the second and third episodes, comparative and consecutive subjective and objective evaluations of the bioadhesive were done. The effects of the following variables were investigated: (1) VAS pain score for 5 consecutive days, (2) profile of aphthous ulcers on days 3 and 5, (3) time to complete relief of pain and healing of the ulcers, (4) diameter of the lesions and necrotic zone.A significant reduction in VAS was recorded following application of the licorice patches on days 2, 3, 4 and 5 compared with the no-treatment group (p < 0.001). Licorice patches caused a significant reduction in the diameter of the inflammatory halo and necrotic center compared with the placebo group (p = 0.03).According to the results of this study, licorice bioadhesive can be effective in the reduction of pain and of the inflammatory halo and necrotic center of aphthous ulcers.

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“…An association between RAU and hypersensitivity to putative strains of Streptococcus sanguis was first hypothesized by Barile et al (1963Barile et al ( , 1968. Bacteria identified as S. sanguis were isolated, frequently in pure culture, from aphthous lesions, and delayed-type hypersensitivity skin reactions occurred in patients with RAU after intradermal injection of vaccines prepared from these isolates.…”

Section: Introductionmentioning

confidence: 96%

“…Although RAU has been clinically described since 1898 (von Mikulicz and Kummel), the cause of the disease remains unresolved. Auto-immunity (Lehner, 1969(Lehner, , 1972Dolby, 1970Dolby, , 1972Rogers et al, 1974;Rogers, 1977), food hypersensitivity (Thomas et al, 1973;Marquardt et al, 1973;Wray, 1982;Wray et al, 1982;Eversole et al, 1982), bacterial hypersensitivity (Barile et al, 1963(Barile et al, , 1968Donatsky and Dabelsteen, 1974;Donatsky, 1975Donatsky, , 1976Donatsky, , 1978, viral infection (Sallay et al, 1971(Sallay et al, , 1973Hooks, 1978;Eglin et al, 1982), and immunoregulatory defects (Greenspan et al, 1981Gadol et al, 1985) have all been proposed as immunopathogenic mechanisms in RAU.…”

Section: Introductionmentioning

confidence: 99%

Humoral Responses and Cross-reactivity to Viridans Streptococci in Recurrent Aphthous Ulceration

1986

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It has been proposed that recurrent aphthous ulceration (RAU) is caused by hypersensitivity to oral streptococci. This hypothesis is based on reports that RAU patients have increased levels of circulating IgG antibodies against oral streptococci, and that rabbit antisera prepared against oral streptococci are cross-reactive with oral mucosa. Using indirect immunofluorescence, we have investigated both of these reported phenomena. End-point titers of serum antibodies against three different strains of oral streptococci were assayed from nine RAU subjects with active ulcers and compared with those of nine control subjects. Titers ranged from 1:2 to 1:64 in both groups and do not appear to have any clinical or immunopathogenic significance. Cross-reactivity was studied using hyperimmune rabbit antisera raised against five different strains of oral streptococci. Homologous bacterial titers ranged from 1:1024 to 1 :8192, but none of these anti-streptococcal sera produced heterologous titers greater than 1:32 with oral mucosa. This apparent low level of cross-reactivity with oral mucosal antigens appears to be non-specific and clinically insignificant. In previous reports, we have used both leucocyte migration and lymphocyte blast transformation to study cell-mediated immunity to viridans streptococci in RAU (Gadol et al., 1985; Greenspan et al., 1985). None of our results supports an immunopathogenic role for oral streptococci in RAU.

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L form of bacteria isolated from recurrent aphthous stomatitis lesions

Cited by 80 publications

References 18 publications

Recurrent Aphthous Stomatitis

Recurrent Aphthous Stomatitis

The efficacy of the bioadhesive patches containing licorice extract in the management of recurrent aphthous stomatitis

Humoral Responses and Cross-reactivity to Viridans Streptococci in Recurrent Aphthous Ulceration

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