With the objective of recognizing the cultural conception of space and development in the Colombian Amazon, an exploratory approach of documentary nature is developed to analyze the history of Amazonian settlement, the cosmogony-cosmology, the enrichment and/or impoverishment that generated the interaction between the indigenous and conquerors in "the creation of the new world," ecological relations, multilingualism, as well as the development of territory since a "geographic-environmental-humanistic" view, and the laws that currently protect indigenous peoples. It is concluded that the history of social relations has framed a syncretism between the visions of the populations about the world, the territory, development and economic interest, which positively and/or negatively feedback the protagonism of the ethnicities, the worldviews, the language, as well as the ways of relating to nature and therefore the indigenous perpetuity in the territory.