Visual perceptual distortions and physical discomfort that cause difficulties in reading are some of the characteristics of Irlen syndrome. This study examined if students with Irlen syndrome, assessed with different reading tasks, present differences in reading skills when compared to those without the condition. Participants were 110 fourth and fifth graders (mean age = 8.6 years), 55 with Irlen syndrome (ISG group) and 55 without the syndrome (control group). Researchers applied the Irlen Reading Perceptual Scale to evaluate the Irlen Syndrome and the PROLEC-R Test to assess reading processes. The results showed significant group differences in Word Reading, Pseudoword Reading, Punctuation Marks, Sentence, and Text Comprehension. Oral comprehension in the auditory modality was not significantly different, which would support the idea that Irlen syndrome seems to be related to visual sensory processes. In conclusion, participants with Irlen syndrome presented impaired reading processes that might affect overall visual comprehension but not oral reading comprehension.