LA SIGNIFICATION DU pH DANS LE TUBE DIGESTIF DE GALLUS DOMESTICUS

Herpol, Claire; Grembergen, G Van

doi:10.1051/rnd:19670104

Cited by 32 publications

(14 citation statements)

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“…1E). This closely matches the pH of the chicken's digestive tract (pH 4.5-7.5 (Herpol and van Gembergen, 1967;Faner, 1942;Winget et al, 1962), with the exception of pH 3.5 for the proventriculus (Winget et al, 1962)). Second, a recent and comprehensive re-evaluation of the nature of soluble InsP 6 in biological systems has concluded that the pentamagnesium salt is the most biologicallyrelevant form of InsP 6 (Torres et al, 2005).…”

Section: Expression and Characterization Of Recombinant Avian Minppmentioning

confidence: 57%

Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's “phosphate crisis”

Cho

Choi

Darden

et al. 2006

Journal of Biotechnology

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Contemporary phytase research is primarily concerned with ameliorating the problem of inadequate digestion of inositol hexakisphosphate (phytate; InsP 6 ) in monogastric farm animal feed, so as to reduce the pollution that results from the high phosphate content of the manure. In the current study we pursue a new, safe and cost-effective solution. We demonstrate that the rate of hydrolysis of InsP 6 by recombinant avian MINPP (0.7 μmol/mg protein/min) defines it as by far the most active phytase found to date in any animal cell (the corresponding activity of recombinant mammalian MINPP is only 0.006 μmol/mg protein/min). Although avian MINPP has less than 20% sequence identity with microbial phytases, we create a homology model of MINPP in which it is predicted that the structure of the phytase active site is well-conserved. This model is validated by site-directed mutagenesis and by use of a substrate analogue, scyllo-InsP 6 , which we demonstrate is only a weak MINPP substrate. In a model chicken cell line, we overexpressed a mutant form of MINPP that is secretion-competent. This version of the enzyme was actively secreted without affecting either cell viability or the cellular levels of any inositol phosphates. Our studies offer a genetic strategy for greatly improving dietary InsP 6 digestion in poultry.

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Section: Expression and Characterization Of Recombinant Avian Minppmentioning

confidence: 57%

Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's “phosphate crisis”

Cho

Choi

Darden

et al. 2006

Journal of Biotechnology

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“…This optimum pH (1.5) was similar despite the pepsin and plant protein source. It is slightly lower than the mean pH (about 2.5 [12,15]) found in the gizzard of broiler chickens fed a commercial feed, or in the stomach of the pig after a meal (between 1.8 and 5.8 [21]). Thus, it seems that in vivo pepsin hydrolysis does not proceed under optimal conditions.…”

mentioning

confidence: 88%

Comparison of pig and chicken pepsins for protein hydrolysis

Crévieu-Gabriel¹,

Gomez²,

Caffin³

et al. 1999

Reprod. Nutr. Dev.

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-The aim of the present study was to compare the degree of proteolysis with pig (PP) and chicken (CP) pepsins in order to find out whether PP can be used instead of CP to simulate gastric hydrolysis in the chicken. First, the pH activity profile of the two pepsins was compared using three substrates. For haemoglobin, CP showed a slightly higher optimal pH than PP, 2.5-3 and 2, respectively. For two plant protein sources (peas, wheat), the optimal pH was similar for the two enzymes, about pH 1.5. For the three substrates tested, CP exhibited a high level of activity over a broader pH range than PP. Second, the susceptibility of the two plant proteins to hydrolysis by each of the two pepsins was studied at pH levels near the chicken gastric pH (1.5-3.5). For PP, pea proteins were hydrolysed more than wheat ones, while, for CP, the hydrolysis was dependent on pH. Therefore (1,5). Alors qu'avec la PP les protéines de pois ont été mieux hydrolysées que celles du blé, dans le cas de la CP le résultat dépend du pH. La classification des deux sources de protéines étudiées dépend donc de l'origine animale de

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“…Early experiments showed a direct correlation between quantity and nature of nutrition and the resultant uric acid excretion (Fisher 1935a(Fisher , 1935b. It was also recognised early on that the pH varies throughout the whole intestinal tract of birds (Herpol & van Grembergen 1967). Other studies suggest that for pigeons, neither the volume of food , nor the levels of protein in the diet (McNabb et al 1973) appear to have an influence on the concentration of uric acid in the urine.…”

Section: Factors Influencing the Acidity Of Ex-cretamentioning

confidence: 99%

Dietary habits of urban pigeons (Columba livia) and implications of excreta pH – a review

Spennemann¹,

Watson²

2017

European Journal of Ecology

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Pigeons are considered to be urban pests, causing untold damage to buildings and potentially impacting the health of humans who come into contact with them or their faeces. Pigeon faecal matter has been implicated in both health impacts and building damage, with the acidity of the excreta playing an important role. Purpose of the Review. This paper is a wide-ranging review of the chemical processes of excreta in the pigeon to aid our understanding of the potential problems of pigeons to buildings and human amenity in the urban space. The natural pH of pigeons is shown to vary based on the bird's and age as well as reproductive stage. Key findings of the review. The influences of the altered diet between the rock dove (the wild progenitor of the feral pigeon) and the feral pigeon are detailed, indicating that the human-based diet of urban pigeons most likely causes the feral pigeon excreta to be more acidic than the rock dove excreta. This higher acidity is due in part to diet, but also to potential increases in faecal and/or uric acid volumes due to the low quality of humanbased diets. Again, this area of interest is highly data deficient due to the few number of studies and unspecified dietary intake before pH measurement. Implications of the review. Humans are increasingly concerned about pigeon populations (and presumably their accumulated faeces) in the urban space, and control comprises a large part of the interaction between humans and feral pigeons. This review provides a greater understanding of feral pigeons and the true effects of their excreta. INTRODUCTION ABSTRACTColumba livia; pH; Foraging; Diet; Excreta KEYWORDS

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LA SIGNIFICATION DU pH DANS LE TUBE DIGESTIF DE GALLUS DOMESTICUS

Cited by 32 publications

References 0 publications

Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's “phosphate crisis”

Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's “phosphate crisis”

Comparison of pig and chicken pepsins for protein hydrolysis

Dietary habits of urban pigeons (Columba livia) and implications of excreta pH – a review

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