Lab-on-a-chip for high frequency acoustic characterization

Gao, Jiaming; Carlier, Julien; Wang, Shengxiang; Campistron, Pierre; Callens, Dorothée; Guo, Shishang; Zhao, Xu; Nongaillard, Bertrand

doi:10.1016/j.snb.2012.11.037

Cited by 7 publications

(5 citation statements)

References 114 publications

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“…Conventional acoustophoresis devices separate cells/particles from the horizontal plane, so the channel width is restricted due to the limited cell/particle displacement. [35][36][37][38][39][40][41][42][43][44][45][46][47] A typical channel width for acoustic separation is normally between 100 and 1000 μm, which results in a relatively small throughput (<1 mL min −1 ). This is an obstacle for applications such as rare cell isolation and transfusion.…”

Section: High-throughput Separationmentioning

confidence: 99%

High-throughput acoustic separation of platelets from whole blood

et al. 2016

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Platelets contain growth factors which are important in biomedical and clinical applications. In this work, we present an acoustic separation device for high-throughput, non-invasive platelet isolation. In particular, we separated platelets from whole blood at a 10 mL/min throughput, which is three orders of magnitude greater than that of existing acoustic-based platelet separation techniques. Without sample dilution, we observed more than 80% RBC/WBC removal & platelet recovery. High throughput, high separation efficiency, and biocompatibility make this device useful for many clinical applications.

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Section: High-throughput Separationmentioning

confidence: 99%

High-throughput acoustic separation of platelets from whole blood

et al. 2016

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“…For the acoustic wave, the device was completely immersed in water using a millifluidic channel with a 5-mm-thick water layer. Considering the absorption coefficient of water for ultrasonic waves, which is 25.6 × 10 −17 s 2 /cm [41], a 200-MHz acoustic wave would quickly attenuate when it propagated in the water. Since the acoustic wave was well confined in LN, and the thickness of the silicon substrate exceeded one hundred micrometers, the acoustic wave was very weak on the boundaries of the silicon substrate.…”

Section: Discussionmentioning

confidence: 99%

“…The device was completely immersed in water using a millifluidic channel [40] with a 5-mm-thick water layer. Considering the absorption coefficient of water for ultrasonic waves, which was 25.6 × 10 −17 s 2 /cm [41], a 200-MHz acoustic wave would quickly attenuate when it propagates in the water and almost decay to zero when it transmits through a 5-mm-thick water layer. Therefore, reflections from the boundaries are negligible.…”

Section: Principle and Modelmentioning

confidence: 99%

Integrated Hybrid Tweezer for Particle Trapping with Combined Optical and Acoustic Forces

Li,

Tong,

Cai

et al. 2023

Applied Sciences

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We propose an on-chip integrated hybrid tweezer that can simultaneously apply optical and acoustic forces on particles to control their motions. Multiple potential wells can be formed to trap particles, and the acoustic force generated by an interdigital transducer can balance the optical force induced by an optical waveguide. For example, by driving the waveguide with an optical power of 100 mW and the interdigital transducer with a voltage of 1.466 V, the particle with a refractive index of 1.4 and a diameter of 5 μm (similar to yeast cells) can be stably trapped on the waveguide surface, and its trapping position is controllable by changing the optical power or voltage.

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“…In any kind of application, we need to favor either one or both types of the generated waves. In the present study, regarding the matching network, promoting the longitudinal waves is sought [19].…”

Section: Increasing the Longitudinal Acoustic Waves Emission By Impedance Matchingmentioning

confidence: 99%

Fabrication and Optimization of High Frequency ZnO Transducers for Both Longitudinal and Shear Emission: Application of Viscosity Measurement using Ultrasound

Dahmani¹,

Zaaroura²,

Salhab³

et al. 2020

Adv. sci. technol. eng. syst. j.

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This paper covers the study of high-frequency (~ 1 GHz) ZnO piezoelectric transducer integrated on a silicon substrate able to generate both compressional and shear acoustic waves. First, to promote the longitudinal mode, an electrical matching of the transducer in this high-frequency range is effectuated. Second, to promote shear waves, new deposition conditions were applied, giving thin zinc oxide films of inclined c-axis. The RF microprobe was used to validate the transducer design and to conduct the viscosity measurements. Thus, the shear and the volume viscosity of a water droplet were measured.

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Lab-on-a-chip for high frequency acoustic characterization

Cited by 7 publications

References 114 publications

High-throughput acoustic separation of platelets from whole blood

High-throughput acoustic separation of platelets from whole blood

Integrated Hybrid Tweezer for Particle Trapping with Combined Optical and Acoustic Forces

Fabrication and Optimization of High Frequency ZnO Transducers for Both Longitudinal and Shear Emission: Application of Viscosity Measurement using Ultrasound

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