Lab-on-a disc platform for particle focusing induced by inertial forces

Κιτσαρά, Μαρία; Aguirre, Gerson R.; Efremov, Vitaly; Ducrée, Jens

doi:10.1117/12.2017438

Cited by 2 publications

(1 citation statement)

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“…A continuously curved channel is impossible to realize in a microfluidic spinning disc, because after the first quadrant, the fluid direction will oppose the centrifugal force and the flow will stop. Another method to induce a Dean flow without needing to reverse the flow direction, with respect to the centrifugal force, is by using an asymmetric curving system on a microfluidic chip, as was described by Di Carlo et al [52] and implemented on a microfluidic disc by Aguirre et al and Kitsara et al [30,53]. Contraction-expansion arrays (CEAs) [54] can generate a secondary flow, because the fluid streamlines follow a curved path as they enter the expansion region, which creates a pressure gradient that results in a Dean flow.…”

Section: Fractionation Mechanismmentioning

confidence: 99%

High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc

et al. 2020

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The fabrication and testing of microfluidic spinning compact discs with embedded trapezoidal microchambers for the purpose of inertial microparticle focusing is reported in this article. Microparticle focusing channels require small features that cannot be easily fabricated in acrylic sheets and are complicated to realize in glass by traditional lithography techniques; therefore, the fabrication of microfluidic discs with femtosecond laser ablation is reported for the first time in this paper. It could be demonstrated that high-efficiency inertial focusing of 5 and 10 µm particles is achieved in a channel with trapezoidal microchambers regardless of the direction of disc rotation, which correlates to the dominance of inertial forces over Coriolis forces. To achieve the highest throughput possible, the suspension concentration was increased from 0.001% (w/v) to 0.005% (w/v). The focusing efficiency was 98.7% for the 10 µm particles and 93.75% for the 5 µm particles.

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